In vivo therapeutic response monitoring by a self-reporting upconverting covalent organic framework nanoplatform

Abstract

An upconverting covalent organic framework nanoplatform is designed for the first time for the near-infrared activated in situ self-reporting of photodynamic therapy in vivo.

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

“…In 2020, Tan et al. used core‐mediated imine polymerization to grow porphyrin‐based COFs on the surface of up‐conversion nanoparticles (UCNP) . When UCNP@COF was irradiated at 980 nm near‐infrared (NIR) light, 654 nm red light emitted by the UCNP excited the porphyrin photosensitizer to produce 1 O 2 .…”

A COF-based nanoplatform for highly efficient cancer diagnosis, photodynamic therapy and prognosis

“…[5][6][7][8] COFs are also promising candidates for biomedical applications owing to their unique stability, biocompatibility and functional diversity. [9][10][11][12] But the poor dispersibility and unsatisfactory bioavailability caused by their large size are still the major bottlenecks for COFs to be used for biomedical applications. [13][14][15][16][17] Nanoscale COFs possessing better dispersibility and higher bioavailability are more suitable for biomedical purposes.…”

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

“…Here, we will introduce the different kinds of methods to make the bread: COF-based oncotherapy examples. Till now, COFs have been used as drug delivery carriers, 221,[396][397][398][399][400][401][402][403] phototherapy reagents, 163,216,223,261,[404][405][406][407][408][409][410] and combination therapy platforms 161,162,220,[411][412][413][414][415] for tumor therapeutics ( Table 5).…”