2014
DOI: 10.1002/term.1854
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In vivovascularization of cell sheets provided better long-term tissue survival than injection of cell suspension

Abstract: Cell sheets have shown a remarkable ability for repairing damaged myocardium in clinical and preclinical studies. Although they demonstrate a high degree of viability as engrafted cells in vivo, the reason behind their survivability is unclear. In this study, the survival and vascularization of rat cardiac cell sheets transplanted in the subcutaneous tissue of athymic rats were investigated temporally. The cell sheets showed significantly higher survival than cell suspensions for up to 12 months, using an in v… Show more

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Cited by 39 publications
(30 citation statements)
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“…In patients with severe MI, heart transplantation is the only efficacious therapy [2]. However, there is a chronic shortage of human donor tissues, and there are rejection complications in recipients.…”
Section: Introductionmentioning
confidence: 99%
“…In patients with severe MI, heart transplantation is the only efficacious therapy [2]. However, there is a chronic shortage of human donor tissues, and there are rejection complications in recipients.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, they contain vascular and lymphatic vessel networks that contribute to cell survival, multiple cellular functions, and metabolic activity. [1] Therefore, numerous methods of fabricating 3D tissues such as cell sheets [2,3] and spheroids [4][5][6] containing endothelial tubular structures have been developed and applied in fundamental research.…”
Section: Fabrication Of Spheroids With Dome-shaped Endothelial Tube Nmentioning
confidence: 99%
“…In the most rapid case, using neonatal rat cell coculture, transplanted tissues are sufficiently supplied with blood after about half a day. 49 In vitro prevascularization does not provide a continuous tubular structure and blood is not immediately supplied to the construct. Blood vessel connections and functional tubular formation depends on in vivo regeneration, which seems to require a particular period of time and thus still limits the final thickness of in vivo engineered tissues.…”
Section: Problem Of Primary Ischemiamentioning
confidence: 99%