<i>Influence of Hypoxia on the Pulmonary Circulation of Nonnarcotized Dogs</i>

Nahas, Gabriel G.; Visscher, Maurice B.; Mather, George W.; Haddy, Francis J.; Warner, Homer R.

doi:10.1152/jappl.1954.6.8.467

Cited by 44 publications

(7 citation statements)

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“…The cardiac output response was not altered to any significant extent by sham operation. The changes in cardiac output and other cardiovascular responses are comparable to those reported by other investigators (10,(13)(14)(15).…”

Section: Methodssupporting

confidence: 89%

Effects of Splenectomy and Beta-Adrenoceptor Blockade on Cardiac Output Response to Acute Hypoxemia

Liang¹,

Huckabee²

1973

J. Clin. Invest.

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A B S T R A C T Acute hypoxemia produced by the inhalation of 8% and 5% oxygen increased cardiac output in intact anesthetized dogs by 38% and 62%, respectively. Although practolol, a cardioselective betaadrenergic blocking agent, reduced the increase in cardiac output in dogs subjected to severe hypoxemia (5% 02 breathing) from 62% to 43%, it only slightly reduced the cardiac output rise in dogs subjected to moderate hypoxemia (8% 02 breathing). Splenectomy, on the other hand, abolished the increase in cardiac output produced by moderate hypoxemia except for a small initial rise, but it reduced the increase in cardiac output during severe hypoxemia only to 37%. The entire increase, except for a small initial rise, disappeared only when splenectomized dogs were pretreated with practolol. Sham operation did not affect the cardiac output response to hypoxemia. It is concluded that an intact spleen is required for a significant portion of the increased cardiac output that occurs during both moderate and severe hypoxemia and that catecholamines do not participate in the regulation of cardiac output unless severe hypoxemia occurs.

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Section: Methodssupporting

confidence: 89%

Effects of Splenectomy and Beta-Adrenoceptor Blockade on Cardiac Output Response to Acute Hypoxemia

Liang¹,

Huckabee²

1973

J. Clin. Invest.

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“…6 The limited information available on the volume of the larger veins is compatible with our finding of 18 per cent of total blood volume. On the basis of anatomic measurements Green 7 gives the proportion of blood in veins 6 mm.…”

Section: Discussionsupporting

confidence: 85%

Estimation of Venous Blood Volume in the Dog by the Indicator-Dilution Method

Milnor

Bertrand

1958

Circulation Research

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The indicator-dilution method of determining cardiac output and mean transit times can be employed to estimate indirectly the volume of blood in the larger veins in vivo although it is difficult to define precisely the peripheral anatomic boundaries of the volume so measured. In 12 anesthetized dogs the "venous" blood volume obtained by multiplying cardiac output and mean transit time from femoral vein to right atrium averaged 16.6 ml./Kg., or 18 per cent of total blood volume. Rapid intravenous infusion of dextran solution caused no significant change in the blood volume of the large veins, heart or lungs.

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“…In the dog, hypoxaemia may cause an increase, a decrease, or no effect on calculated pulmonary vascular resistance. Using the dilution technique, the changes in resistance have ranged from -15 to +20% (Nahas, Visscher, Mather, Haddy, and Warner, 1954). The anaesthesia could also have played a significant role in producing changes in cardiac output, regional blood distribution, and venous return (Scarborough, 1957).…”

Section: Resultsmentioning

confidence: 99%

Treatment of experimental pulmonary embolism by main pulmonary arterial infusion of a fibrinolytic agent

Magtira¹,

Wells²,

Llamas³

et al. 1969

Thorax

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The continuous instillation of plasmin (Thrombolysin) directly into the main pulmonary artery of greyhounds, using one half of the systemic doses, was found to be more effective in accelerating or enhancing in vivo lysis of artificially produced pulmonary emboli than systemic intravenous infusion. Animals which received direct pulmonary arterial instillations of Thrombolysin showed remarkably few macroemboli. By light microscopy, these clots showed zones of lysis mainly in the central portions of the clots. We suggest that the flow-guided catheterization of the main pulmonary artery used in this study on greyhounds can be applied to critically ill human subjects, as shown by earlier studies (Magtira, Winkler, Duprey, and Baum, 1966). Continuous infusions of thrombolytic agents directly into the main pulmonary artery might then offer an effective therapy for human pulmonary embolism, especially during that critical period following a massive or sUbmassive embolic episode.

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Influence of Hypoxia on the Pulmonary Circulation of Nonnarcotized Dogs

Cited by 44 publications

References 0 publications

Effects of Splenectomy and Beta-Adrenoceptor Blockade on Cardiac Output Response to Acute Hypoxemia

Effects of Splenectomy and Beta-Adrenoceptor Blockade on Cardiac Output Response to Acute Hypoxemia

Estimation of Venous Blood Volume in the Dog by the Indicator-Dilution Method

Treatment of experimental pulmonary embolism by main pulmonary arterial infusion of a fibrinolytic agent

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