The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

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London ( 1 ) used angiostomy cannulae for the purpose of directing hypodermic needles into the lwger thoracic vessels. Daly(2) reported the measurement of pulmonary arterial pressure in the unanesthetized dog by means of the London Type cannulae. Johnson, Hamilton, Katz and Weinstein(3) in the same year studied the dynamics of pulmonary circulation by means of hypodermic manometers. the needles being placed in the aorta, pulmonar-artery and pulmonary vein. Hamilton, \Yoodbury and Vogt (4) studied differential pressures in the lesser circulation of the unanesthetized dogs using angiostomy cannulae and hypodermic manometers. Katz and Steinitz ( 5 ) developed a modification of the angiostomy cannulae used by Hamilton, and used their cannulae in measuring pul-* This work was supported in part by contract with the -Alaskan Air Command Arctic Aerolmedical h boratory. Ladd AFB, Alaska. t Paper No. 2813, Scientific Journal Series, Mmnesota -4gricultural Experiment Station. monary arterial pressures.The purpose of this paper is to report the development of a #technic permitting direct access to the atria and large thoracic vessels of unanesthetized dogs under conditions which may be compared to normal.Methods. Two varieties of cannulae were developed and used. The first variety, shown in Fig. 1, a., consists of silver tubes (3 mm outside diameter) fi.tted with perforated silver plates, one type of which is trough-shaped, to fit over the left pulmonary artery. A second type is flat land oval in shape, suitable for attachment t o the left atrium. The length of each silver tube is such that its distal end, the heart serving as reference point, will lie immediately under the skin of the chest wall. The perforated silver plates are made from 2 mm silver stock. The plate attachment that is fitted over the left pulmonary artery is 8 mm long and of sufficient width so that when bent in a semicircle of the correct radius it extends over half the circumference of the