isoCitric dehydrogenase and glutamic acid synthesis in animal tissues

The action of sulphydryl inhibitors upon isocitric dehydrogenase with especial reference to the behaviour of some trivalent arsenicals

“…The -SR nature of i8ocitric dehydrogenase is still in some doubt because Adler, Euler, Gunther & Plass (1939) stated that the enzyme from pig heart was sensitive to iodoacetic acid, whereas Barron & Singer (1945) said that the enzyme from liver was not affected by -SH reagents. It seemed important to examine the effect of arsenical substances on this enzyme in relation to other arsenical studies in this laboratory.…”

Isocitrate dehydrogenase and related oxidative decarboxylases

“…In 1939, Adler et al [6] first prepared isocitric dehydrogenase free of aconitase from acetone powders of pig heart muscle, showed that Mn2+ or Mg2+ and NADP were essential co-factors and established the stoichiometry of the reaction. They reported wide distribution of the enzyme in animal and plant tissues and in yeasts.…”

“…A conformational change of the enzyme may be involved [42]. 6 [47]. If it is formed as a molecular intermediate, oxalosuccinate must be firmly bound to the enzyme in a complex that does not reach a significant steady-state concentration.…”

THE INFLUENCE OF LIGHT, TEMPERATURE, AND SOME ENZYME POISONS UPON THE TOTAL ORGANIC ACID CONTENT OF LEAF TISSUE OF KALANCHOE DAIGREMONTIANA (HAMET AND PERRIER)

“…Iodoacetic acid may influence acid breakdown by its inhibitory action upon isocitric acid dehydrogenase (2), if it is assumed that some sort of tricarboxylic acid cycle occurs in succulent plant tissues. This same action of iodoacetate may account both for the inhibition of acid breakdown and the inhibition of acid accumulation.…”