For any reduced amalgamated free product C * -algebra (A, E) = (A 1 , E 1 ) * D (A 2 , E 2 ), we introduce and study a canonical ambient C * -algebra ∆T(A, E) of A which generalizes the crossed product arising from the canonical action of an amalgamated free product group on the compactification of the associated Bass-Serre tree. Using an explicit identification of ∆T(A, E) with a Cuntz-Pimsner algebra we prove two kinds of "amenability" results for ∆T(A, E); nuclearity and universality. As applications of our framework, we provide new conceptual, and simpler proofs of several known theorems on approximation properties, embeddability, and KK-theory for reduced amalgamated free product C * -algebras.