<i>Klebsiella pneumoniae</i>Liver Abscess

Jun, Jae Bum

doi:10.3947/ic.2018.50.3.210

Cited by 90 publications

(89 citation statements)

References 44 publications

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“…It is an aetiological agent of septicaemia, pneumonia, soft tissue infections, urinary tract infections, surgical site infections and catheter-related infections (Podschun and Ullmann, 1998;Abbot, 2003). This pathogen can also cause community-acquired infections, and over the past three decades, K. pneumoniae has become a major cause of pyogenic liver abscess, complicated with metastatic meningitis and endophthalmitis, and this emerging disease has been reported worldwide (Ko et al, 2002;Ohmori et al, 2002;Okano et al, 2002;Chung et al, 2008;Tsai et al, 2008;Jun, 2018;Wang et al, 2018). Another study demonstrated the important role of K. pneumoniae in bacteraemic community-acquired pneumonia (CAP), as this pathogen accounted for more than half of CAP cases in Taiwan (49/95, 51.5%) during 2001(Lin et al, 2010.…”

Section: Introductionmentioning

confidence: 99%

Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types

Pan

Lin

Chen

et al. 2019

Microbial Biotechnology

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Summary Klebsiella pneumoniae is an important human pathogen causing opportunistic nosocomial and community‐acquired infections. A major public health concern regarding K. pneumoniae is the increasing incidence of multidrug‐resistant strains. Here, we isolated three novel Klebsiella bacteriophages, KN 1‐1, KN 3‐1 and KN 4‐1, which infect KN 1, KN 3 and K56, and KN 4 types respectively. We determined their genome sequences and conducted a comparative analysis that revealed a variable region containing capsule depolymerase‐encoding genes. Recombinant depolymerase proteins were produced, and their enzymatic activity and specificity were evaluated. We identified four capsule depolymerases in these phages that could only digest the capsule types of their respective hosts. Our results demonstrate that the activities of these capsule depolymerases were correlated with the host range of each phage; thus, the capsule depolymerases are host specificity determinants. By generating a capsule mutant, we demonstrate that capsule was essential for phage adsorption and infection. Further, capsule depolymerases can enhance bacterial susceptibility to serum killing. The discovery of these phages and depolymerases lays the foundation for the typing of KN 1, KN 3, KN 4 and K56 Klebsiella and could be useful alternative therapeutics for the treatment of K. pneumoniae infections.

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Section: Introductionmentioning

confidence: 99%

Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types

Pan

Lin

Chen

et al. 2019

Microbial Biotechnology

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“…HA is invaded by microbes via bile ducts, blood stream (hepatic artery and portal vein) or by contiguous spread [11,12] and PLA is accused of the majority causes of HA [1] . Numerous studies show the risk factors which predispose patients to PLA, including immune-compromised state (immunodeficiency, chemotherapy and etc.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and pathogens of pediatric pyogenic liver abscess in Beijing Children’s Hospital, China

Xie¹,

Guo²,

Liu³

et al. 2020

Preprint

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Background: Data on pyogenic liver abscess (PLA) of children in China have been limited.Method: We retrospectively reviewed PLA cases from Hospital. Clinical features and pathogens were analyzed.Results: We diagnosed 15 PLA patients in our center. Median age of onset was 3.2 years and the median diagnostic time was 9 days. Four patients (26.7%) had underlying diseases and seven patients (46.7%) had multiple organ involvement. The sensitivity achieved 100% when ultrasound and contrast-enhanced CT scan were combined use to diagnose PLA. Two patients were defined pathogen through metagenomic next-generation sequencing (mNGS). Finally, eleven patients (73.3%) were cured during follow-up time and four patients (26.7%) dead. Compared to the survival group and the death group, the patients in death group were more likely to have multiple organ involved (100 vs. 27%, P < 0.05) and bilateral lobe occupied ( P < 0.05) .Conclusions: PLA often occurs in patients with underlying disease. Multiple organs involved may lead to poor prognosis. mNGS can be a new method to detect pathogen. HighlightsPyogenic liver abscess often occurs in patients with underlying disease.Multiple organs involved and bilateral lobe occupied may lead to poor prognosis.Metagenomic next-generation sequencing could be a new method to make diagnosis.

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“…The recent improvement in public health in Korea has resulted in reducing the prevalence of amebic liver abscess, whereas PLA accounts for 73%-96% of liver abscesses, with KP being the primary causative pathogen [8]. In particular, immunocompromised patients with KP-PLA and conditions such as DM or cancer are at a risk of severe complications, including bacteremia, septic shock, and multiple organ failure [8].…”

Section: A B C Dmentioning

confidence: 99%

Gastric cancer and adenomatous colorectal polyp concomitant with pyogenic liver abscess and bacteremia

Kang

Kwon

Kim

2020

Yeungnam Univ J Med

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Pyogenic liver abscess (PLA) is defined as a mass of cystic lesions in the liver with clinical manifestations, including fever, chills, and abdominal pain, which can be caused by either bacterial, fungal, or parasitic organisms [1][2][3]. The most common causative pathogen of PLA is Klebsiella pneumoniae (KP). KP can invade the liver via many routes, including the biliary tract, hepatic arteries, and portal vein and through direct invasion from an adjacent infected organ [4][5][6]. Hematogenous PLA is closely associated with colon-Synchronous gastric cancer and adenomatous colorectal polyp in patients with Klebsiella pneumoniae-induced pyogenic liver abscess (KP-PLA) and bacteremia is a rare presentation. A 58-year-old man with a 6-month history of diabetes mellitus (DM) presented with febrile sensation and dull abdominal pain in the right upper quadrant of the abdomen. Subsequent to laboratory test results and abdominal computed tomography findings, KP-PLA with bacteremia was diagnosed. After intravenous antibiotic administration, his symptoms improved, and upper endoscopy and colonoscopy were performed to evaluate the cause of KP-PLA. Biopsy specimens of the prepyloric anterior wall revealed a moderately differentiated adenocarcinoma. Endoscopic mucosal resection of the colon revealed high-grade dysplasia. Early gastric cancer (EGC) and adenomatous colorectal polyps with high-grade dysplasia concomitant with KP-PLA and bacteremia were diagnosed in our patient who had DM. Intravenous antibiotic treatment for KP-PLA, subtotal gastrectomy for EGC, and colonoscopic mucosal resection for the colon polyp were performed. After 25 days of hospitalization, subtotal gastrectomy with adjacent lymph node dissection was performed. Follow-up ultrasound imaging showed resolution of the abscess 5 weeks post-antibiotic treatment, as well as no tumor metastasis. Upper gastrointestinal endoscopy and colonoscopy should be performed to evaluate gastric cancer in patients with PLA or bacteremia, accompanied with DM or an immunocompromised condition.

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Klebsiella pneumoniaeLiver Abscess

Cited by 90 publications

References 44 publications

Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types

Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types

Clinical characteristics and pathogens of pediatric pyogenic liver abscess in Beijing Children’s Hospital, China

Gastric cancer and adenomatous colorectal polyp concomitant with pyogenic liver abscess and bacteremia

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