2021
DOI: 10.1155/2021/6662649
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L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus

Abstract: Pumpkin has received significant attention due to its nutritional compounds that have antioxidant, antifatigue, and anti-inflammatory effects. This study is aimed at assessing the antidepressant-like effect of L. Cucurbita pepo, sweet pumpkin, in an animal model of chronic unpredictable mild stress (CUMS) and investigating its effect on the histological structure of hippocampus compared to fluoxetine. Forty male albino rats assigned into the negative control, positive control (CUMS), and Flu-treated and pumpki… Show more

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“…All rats were raised in standard experimental conditions. To recreate chronically stressful conditions, the chronic unpredictable mild stress (CUMS) procedure was on the basis of a previously described method of minor amendments and supplements (Ayuob et al, 2021;Guan et al, 2021). PS group rats were exposed to one of seven different stressors was randomly chosen to stimulate daily for 4 weeks.…”
Section: Cums Proceduresmentioning
confidence: 99%
“…All rats were raised in standard experimental conditions. To recreate chronically stressful conditions, the chronic unpredictable mild stress (CUMS) procedure was on the basis of a previously described method of minor amendments and supplements (Ayuob et al, 2021;Guan et al, 2021). PS group rats were exposed to one of seven different stressors was randomly chosen to stimulate daily for 4 weeks.…”
Section: Cums Proceduresmentioning
confidence: 99%