Lactobacillus plantarum 299: Beneficial in vitro immunomodulation in cells extracted from inflamed human colon

Abstract

Lactobacillus plantarum demonstrates beneficial immunomodulatory activity by increasing IL-10 synthesis and secretion in macrophages and T-cells derived from the inflamed colon. This may provide a mechanism through which probiotic bacteria ameliorate inappropriate inflammation and induce tolerance.

Lactobacillus plantarum Prevents the Upregulation of Adhesion Molecule Expression in an Experimental Colitis Model

“…However, L. plantarum administration did not reduce levels of these cytokines significantly. A similar effect was observed by Pathmakanthan et al [44]. This group reported that though Lactobacillus plantarum demonstrated beneficial immunomodulatory activity by increasing IL-10 synthesis and secretion in macrophages and T-cells derived from the inflamed colon, no significant increases in IL-1b, TNF-a, or IFN-c were observed after L. plantarum treatment.…”

Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun

“…Several studies have described probiotic Lactobacillusmediated suppression of mammalian TNF production by murine macrophages, 51,62 human intestinal epithelial cells, 63 human mononuclear cells, 64 or ex vivo studies with intestinal mucosa from patients with CD. 10 The current study described TNF suppression via factor(s) produced by specific strains of humanindigenous probiotic L. reuteri.…”

Rapid discrimination and classification of the Lactobacillus plantarum group based on a partial dnaK sequence and DNA fingerprinting techniques

“…Moreover, numerous studies have demonstrated that the L. plantarum subsp. plantarum strain provides beneficial effects to the immune system (Bujalance et al 2007;Pathmakanthan et al 2004), especially in treating inflammatory disease and mitigating pathogenic infection (Connelly 2008). Inconceivably, more than 28% of commercial probiotic products are mislabelled at the genus or species level (Huys et al 2006).…”