Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model

Abstract

Objective Probiotics are beneficial in human health. In this study, we investigated the effect of probiotics on absorption of amlodipine, a dihydropyridine calcium antagonist used in the treatment of angina and hypertension, in a rabbit model. Methods Lactobacillus plantarum IS-10506 probiotic was administered for 14 days to male New Zealand rabbits. Blood samples were collected before and after probiotic supplementation. Amlodipine (10 mg) was then administered to all groups. Blood samples from a marginal vein were withdrawn at 5, 15, 30, 60, and 120 minutes to determine amlodipine concentrations in rabbit plasma. Results Amlodipine concentrations in the L. plantarum IS-10506 group were 4.95 ± 1.22, 8.71 ± 0.69, and 12.48 ± 2.53 ng/ml, and those in the control group were 1.69 ± 0.31, 3.89 ± 1.23, and 7.17 ± 1.85 ng/ml at 30, 60, and 120 minutes, respectively after administration of amlodipine. Amlodipine concentrations in the L. plantarum IS-10506 group were significantly higher than those in the control group at 30, 60, and 120 minutes after amlodipine administration. Conclusion Our results suggested that supplementation of L. plantarum IS-10506 significantly increases amlodipine plasma concentrations in rabbits.

Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals

“…Clear examples can be seen in rats fed with probiotics, who had a significant increase of amiodarone (antiarrhythmic agent) bioavailability [88]. A similar is noted in diabetic rats after they received gliclazide (antihyperglycemic agent) [89] and in rabbits after the administration of amlodipine (antiarrhythmic agent) [90]. Authors that studied amiodarone [88] proposed that the increase of its bioavailability by almost 43% is due to a decrease of pH in the intestine, which consequently, facilitated ionization of the amiodarone and impacted amiodarone transit.…”

“…As the probiotic survival differs for varies bacterial species, to define the specific strain, collecting feces can be used for studying probiotics in vivo. Other approaches include intestinal intubation or performing mucosal biopsies [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ,…”

“…Altogether, the recent developments of food processing technologies and constant demands from the consumers regarding the more nutritious and safe food products, fruit juices with added probiotics are soon expected to become a new class of functional foods and important element on general food markets, as well as an integral part of proper nutrition [ 143 , 144 ]. This drive is additionally fostered by an increase in vegetarianism where some companies already have probiotic fruit juice beverages in their portfolio for those seeking a healthy lifestyle [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 ...…”

Role of L. plantarum KX519413 as Probiotic and Acacia Gum as Prebiotic in Gastrointestinal Tract Strengthening

“…There was a usual increase in the counts of Hb and RBCs in mice administered with L. plantarum MBTU-HK1 and acacia gum (i.e., in the probiotic group and the synbiotic group) compared with the control. [21] has reported that there was a significant increase in RBCs in an L. plantarum IS-10506-supplemented animal group, which plays a role in tissue oxygen delivery. Experiments in [22] concluded that the degradation of acacia gum brings about short chain fatty acids, which promote fetal hemoglobin expression in RBCs.…”

Bioavailability Based on the Gut Microbiota: a New Perspective

“…Compared with amlodipine monotherapy, coadministration with Lactobacillus plantarum IS-10506 in rabbits significantly enhanced the amlodipine concentration. The authors speculated that L. plantarum IS-10506 could enhance red blood cells and hematocrit, leading to a lower sedimentation rate and increased levels of plasma proteins, which bind amlodipine (147). In addition, a live bacterial suspension of the probiotic Escherichia coli Nissle 1917 enhanced the bioavailability of amiodarone, which is an antiarrhythmic drug, in rats (148), and mixed cultures of Lactobacillus acidophilus, Bifidobacterium lactis, and Lactobacillus rhamnosus increased the bioavailability of gliclazide, an antidiabetic drug, in diabetic rats (149).…”