<i>Lactobacillus rhamnosus</i>
            GG components, SLP, gDNA and CpG, exert protective effects on mouse macrophages upon lipopolysaccharide challenge

Qi, Sirui; Cui, Yanjun; Liu, J.X.; Luo, Xin; Wang, Haifeng

doi:10.1111/lam.13255

Cited by 37 publications

(28 citation statements)

References 35 publications

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“…S.R. Qi and co-workers [ 117 ] published a report that indicated the importance of the individual components to the cell line treated with LPS. The macrophage cell line RAW 264.7 with the induced inflammatory state was treated with a surface layer protein, genomic DNA, and unmethylated cytosine–phosphate–guanine-containing oligodeoxynucleotides, alone or in combination.…”

Section: Probiotics Treatment and Protection From Ibdmentioning

confidence: 99%

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

2020

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Inflammatory bowel disease (IBD), which affects millions of people worldwide, includes two separate diseases: Crohn’s disease (CD) and ulcerative colitis (UC). Although the background (chronic inflammatory state) and some of the symptoms of CD and UC are similar, both diseases differ from each other. It is becoming clear that a combination of many factors, in particular genetic background, host immune response and microbial reduced diversity status are associated with IBD. One potential strategy to prevent/treat IBD is gut modulation by probiotics. Over the last twenty years, many publications have focused on the role of probiotics in the course of IBD. The review discusses the utility of different strains of probiotics, especially Bifidobacterium spp., in all factors potentially involved in the etiology of IBD. The probiotic modulatory properties among different study models (cell lines, animal models of colitis, clinical study) are discussed and probiotic usefulness is assessed in relation to the treatment, prevention, and remission of diseases.

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Section: Probiotics Treatment and Protection From Ibdmentioning

confidence: 99%

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

2020

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“…Lactobacillus rhamnosus GG components exert an anti-inflammation effect on epithelial cells such as mouse macrophage with a protective effect [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus rhamnosus GG (ATCC 53103) for the Management of Infantile Colic: A Randomized Controlled Trial

et al. 2020

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Background: The aim of this study was to investigate the efficacy of Lactobacillus rhamnosus ATCC 53103 together with the maternal diet avoidance of cow’s milk in treating infantile colic. Methods: Forty-five colicky breastfed infants were consecutively randomized to receive L. rhamnosus for 28 days at a dosage of 5 × 109 cfu per day or placebo. Faecal samples were collected from each subject before starting supplementation and at the end of the study period and were immediately analysed. Faecal calprotectin was detected via a quantitative assay. The total bacterial load and selected bacterial species were evaluated using real-time TaqMan PCR. Results: After supplementation for 28 days with Lactobacillus rhamnosus ATCC 53103, median full-force daily crying was reduced (104 versus 242 min, p < 0.001) and the values of faecal calprotectin decreased significantly (p = 0.026). Furthermore, the probiotic increased the abundance of Lactobacillus (p = 0.048) and total bacteria (p = 0.040); all these effects were not observed in the placebo group. Conclusion: Infants treated with Lactobacillus rhamnosus ATCC 53103 for 28 days, in association with the elimination of cow’s milk from the maternal diet, presented some interesting features related to the effect of this probiotic treatment: reductions in crying time and faecal calprotectin, with increased total bacteria and Lactobacillus. To validate these results, a double-blind, placebo-controlled trial on a larger cohort is required.

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“…However, probiotic-derived oligonucleotides may also exert an anti-inflammatory effect, for example, via the inhibition of NF-кB in intestinal epithelial cell lines [97]. Another report showed that gDNA and CpG motifs significantly decreased the LPS-induced IL-6 mRNA levels in RAW264.7 macrophages [201]. Importantly, oligonucleotides derived from bacteria can differ in activity due to the experimental conditions, such as the presence or absence of inflammatory stimuli.…”

Section: Tlr Ligands: Oligonucleotidesmentioning

confidence: 99%

Molecular and Cellular Mechanisms Influenced by Postbiotics

Jastrząb

Graczyk

Siedlecki

2021

IJMS

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In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a plethora of functions, including the synthesis of bioactive products, metabolism of dietary compounds, and immunomodulation, both through attenuation and immunostimulation. An imbalance in the microbiota population, i.e., dysbiosis, has been linked to many human pathologies, including various cancer types and neurodegenerative diseases. Targeting gut microbiota and microbiome–host interactions resulting from probiotics, prebiotics, and postbiotics is a growing opportunity for the effective treatment of various diseases. As more research is being conducted, the microbiome field is shifting from simple descriptive analysis of commensal compositions to more molecular, cellular, and functional studies. Insight into these mechanisms is of paramount importance for understanding and modulating the effects that microbiota, probiotics, and their derivatives exert on host health.

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Lactobacillus rhamnosus GG components, SLP, gDNA and CpG, exert protective effects on mouse macrophages upon lipopolysaccharide challenge

Cited by 37 publications

References 35 publications

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

Lactobacillus rhamnosus GG (ATCC 53103) for the Management of Infantile Colic: A Randomized Controlled Trial

Molecular and Cellular Mechanisms Influenced by Postbiotics

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