<i>Lantana camara</i> Linn root extract-mediated gold nanoparticles and their <i>in vitro</i> antioxidant and cytotoxic potentials

Ramkumar, Rajendiran; Balasubramani, Govindasamy; Raja, Ramalingam Karthik; Raja, Manickam; Govindan, R.; Girija, E. K.; Perumal, Pachiappan

doi:10.1080/21691401.2016.1276923

Cited by 30 publications

(5 citation statements)

References 59 publications

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“…The strong surface plasmon resonance (SPR) was located at 566 nm, suggesting the fabrication of stable AuNPs by MEL. Typical AuNPs show peaks at wavelengths between 540 to 570 nm (Das et al 2014; Gómez-Graña et al 2017; Ramkumar et al 2017; Singh et al 2017). There is no noticeable change at the peak after 30 days; we deduced that MEL was acting as an excellent stabilizing agent and hinder the aggregation.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of gold nanoparticles derived from mannosylerythritol lipid and evaluation of their bioactivities

et al. 2019

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In this study, we introduce a simple and green method for synthesis of gold nanoparticles (AuNPs) using microbial glycolipid mannosylerythritol lipid (MEL) produced from Ustilago maydis CGMCC 5.203 and to evaluate their biomedical activities. MEL was found 10.3 g/L using sunflower oil. The formation of MEL-AuNPs was verified using UV–visible spectrum, XRD, TEM, FTIR, SEM, and EDX. In the biomedical examinations, MEL-AuNPs demonstrated potential cytotoxicity against HepG2 cells, and IC 50 values were found to be 100 and 75 µg/mL for 24 h and 48 h of exposure, respectively, which indicates its good performance against cancer cells. The IC 50 value of MEL-AuNPs was found to be 115 and 124 µg/mL for DPPH and ABTS scavenging activities, respectively. The biosynthesized MEL-AuNPs significantly inhibited cell growth of pathogenic Gram-positive and Gram-negative bacteria. These findings indicated that MEL plays a crucial role in the rapid biofabrication method of metallic NPs possessed the potential of biomedical activities.

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Section: Discussionmentioning

confidence: 99%

Synthesis of gold nanoparticles derived from mannosylerythritol lipid and evaluation of their bioactivities

et al. 2019

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“…The IR peaks for amide I and amide II arise owing to carbonyl stretch were reported on the AuNPs synthesized from the same plant 26 . This may be the reason for the reduction of metal ions while using the leaf extract for the synthesis of NPs indicates the binding of the nanoparticles with biomolecules 27 .…”

Section: Resultsmentioning

confidence: 90%

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2021

IJPSR

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“…Although the effect of L. camara extracts was studied on different cancer cell lines, only a few studies are there so far that investigated the effect of L. camara extract on triple negative breast cancer cells. Ramkumar et al reported cytotoxic properties of L. camara root extract-derived gold nanoparticles on MDA-MB-231 cells (Ramkumar et al, 2017) and in a recent study, El-Din et al showed that methanolic extract of L. camara leaves could exert cytotoxic effect on several cancer cell lines including MCF-7 and MDA-MB-231 breast cancer cells; however, the mechanism of cytotoxicity in breast cancer cell lines was not investigated (El-Din et al, 2022). More recently, Mishra et al reported that extracts of the whole Lantana camara plant harbours cytotoxic effect against triple negative MDA-MB-231 cells although the mechanism of cytotoxicity was unexplored for this cell line (Mishra et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Effect ofLantana camaraethanolic leaf extract on survival and migration of MDA-MB-231 triple negative breast cancer cell line

Pal

Sanyal

Das

et al. 2023

Preprint

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Breast cancer is considered as a leading cause of cancer related death worldwide. The development of chemotherapeutic resistance and the production of undesirable side effects steer the search for new potential candidates with therapeutic implications. Lantana camara has been reported to cure a number of ailments, with few studies showing its cytotoxic effect on breast cancer cell lines. However, the impact of Lantana camara on triple negative breast cancer cells is largely obscure to date. The present study investigated the effect of ethanolic extract of Lantana camara leaves on the triple negative breast cancer cell line, MDA-MB-231. We found that Lantana camara leaf extract induced cytomorphological changes and exhibited a growth inhibitory effect on MDA-MB-231 cells in a dose-dependent manner. The extract was observed to induce G0/G1 cell cycle arrest. Nuclear staining of the cells exposed to Lantana camara leaf extract suggested the presence of condensed nuclei and the result of flow cytometry analysis confirmed cell death by apoptosis. Lantana camara leaf extract also reduced the migration of MDA-MB-231 cells as evidenced by the wound healing assay results. In summary, this study demonstrates the efficacy of the extract to produce growth-inhibitory and anti-migratory effects on MDA-MB-231 cells. Our results thus suggest that Lantana camara leaf extract can be considered a potent source of chemotherapeutic agents for triple-negative breast cancer treatment.

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Lantana camara Linn root extract-mediated gold nanoparticles and their in vitro antioxidant and cytotoxic potentials

Cited by 30 publications

References 59 publications

Synthesis of gold nanoparticles derived from mannosylerythritol lipid and evaluation of their bioactivities

Synthesis of gold nanoparticles derived from mannosylerythritol lipid and evaluation of their bioactivities

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Effect ofLantana camaraethanolic leaf extract on survival and migration of MDA-MB-231 triple negative breast cancer cell line

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