<i>Leishmania infantum</i> and Human Visceral Leishmaniasis, Argentina

Barrio, Alejandra; Parodi, Cecilia; Locatelli, Fabricio M.; Mora, María C.; Basombrío, Miguel Á.; Korenaga, Masaaki; Hashiguchi, Yoshihisa; Bustos, María Fernanda García; Gentile, Alberto; Marco, Jorge Diego

doi:10.3201/eid1802.110924

Cited by 21 publications

(25 citation statements)

References 10 publications

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“…In Argentina the leishmaniases are in the northern region, and seem to be spreading to the center of the country. Here we are reporting cases of CanL in several cities located at northeast of the country, with most of the cases originating in Moreover, at least one of them, LiA2, has also been associated with a human VL case in the country, suggesting a connection between these two hosts in an autochthonous transmission cycle (Barrio et al, 2012).…”

Section: Discussionmentioning

confidence: 96%

“…An invasion of the cycles by an accidental host, for example in deforestation activities, could have triggered the occurrence of sporadic cases of human visceral leishmaniasis, such as happened in Salta province, in northwestern Argentina (Barrio et al, 2012). This parasite could also be transferred from its wild source to domestic animals, like the dogs, that in the appropriate circumstances, could change their status from accidental host to reservoirs, establishing an urban transmission cycle, as happened in Posadas city (Acardi et al, 2010).…”

Section: Discussionmentioning

confidence: 97%

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Genetic and clinical characterization of canine leishmaniasis caused by Leishmania (Leishmania) infantum in northeastern Argentina

Barroso

Nevot²,

Hoyos

et al. 2015

Acta Tropica

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Genetic and clinical characterization of canine leishmaniasis caused by Leishmania (Leishmania) infantum in northeastern Argentina

Barroso

Nevot²,

Hoyos

et al. 2015

Acta Tropica

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“…Only two cases of HVL were observed recently in the study area. One was published 12 and the other has so far been reported to the Ministry of Public Health. In this study, the probable sites *Address correspondence to Miguel A. Basombrío, Instituto de Patología Experimental, Universidad Nacional de Salta, Av.…”

Section: Methodsmentioning

confidence: 99%

Visceral Leishmaniasis Caused by Leishmania infantum in Salta, Argentina: Possible Reservoirs and Vectors

Barroso¹,

Marco²,

Locatelli³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini-and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezzii/Lu. sallesi (cortelezzii complex). The focal appearance of leishmaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.

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“…VL affects humans and canids; canids are identified as the main reservoir of the parasite ( 1 ). This zoonosis has been endemic in northeastern Brazil for several centuries, but it has been recently expanding to southern areas of the South American continent ( 2 – 4 ). In 2010, the presence of the vector L. longipalpis sand flies was recorded for the first time in Uruguay ( 5 ); the right environmental conditions, the presence of competent sand fly vectors, and the constant appearance of new cases of canine and human leishmaniasis in border countries have made Uruguay susceptible to VL transmission ( 5 ).…”

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confidence: 99%