<i>Lippia gracilis</i> essential oil in β‐cyclodextrin inclusion complexes: an environmentally safe formulation to control <i>Aedes aegypti</i> larvae

Galvão, Juliana Gouveia; Cerpe, Patricia; Santos, Darlisson A; Gonsalves, Joyce Kmc; Santos, Adriana J.; Nunes, Rafaela K.V.; Lira, Ana Amélia Moreira; Alves, Péricles Barreto; Corte, Roseli La; Blank, Arie Fitzgerald; Silva, Gabriel Francisco da; Cavalcanti, Sócrates C.H.; Nunes, Rogéria de Souza

doi:10.1002/ps.5138

Cited by 21 publications

(12 citation statements)

References 30 publications

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“…The β-CD showed two endothermic events between 63.80–142.16 °C, and 308.71–343.18 °C. The first endothermic event is related to the loss of water and the second event is related to its melting peak [ 19 ], similar to results obtained by other studies [ 18 , 22 , 23 , 24 ].…”

Section: Resultssupporting

confidence: 82%

“…Thermal analysis is a crucial tool to suggest the formation of inclusion complexes [ 19 ]. We have used Differential Scanning Calorimetry (DSC) and Thermogravimetry/Derivative Thermogravimetry (TG/DTG) to study the physical properties of the inclusion complexes as a function of temperature and time.…”

Section: Resultsmentioning

confidence: 99%

“…However, the most significant difference was found in the CO method (1:1) between 30–170 °C with a reduction in the peak of the thermogravimetric curve ( Figure 3 B). According to Galvão et al [ 19 ], the replacement of the water molecule found in the internal cavity of the β-CD generates an equilibrium of dynamic complexation.…”

Section: Resultsmentioning

confidence: 99%

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β-Cyclodextrin/Isopentyl Caffeate Inclusion Complex: Synthesis, Characterization and Antileishmanial Activity

et al. 2020

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Isopentyl caffeate (ICaf) is a bioactive ester widely distributed in nature. Our patented work has shown promising results of this molecule against Leishmania. However, ICaf shows poor solubility, which limits its usage in clinical settings. In this work, we have proposed the development of an inclusion complex of ICaf in β-cyclodextrin (β-CD), with the aim to improve the drug solubility, and thus, its bioavailability. The inclusion complex (ICaf:β-CD) was developed applying three distinct methods, i.e., physical mixture (PM), kneading (KN) or co-evaporation (CO) in different molar proportions (0.25:1, 1:1 and 2:1). Characterization of the complexes was carried out by thermal analysis, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and molecular docking. The ICaf:β-CD complex in a molar ratio of 1:1 obtained by CO showed the best complexation and, therefore, was selected for further analysis. Solubility assay showed a marked improvement in the ICaf:β-CD (CO, 1:1) solubility profile when compared to the pure ICaf compound. Cell proliferation assay using ICaf:β-CD complex showed an IC50 of 3.8 and 2.7 µg/mL against L. amazonesis and L. chagasi promastigotes, respectively. These results demonstrate the great potential of the inclusion complex to improve the treatment options for visceral and cutaneous leishmaniases.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

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β-Cyclodextrin/Isopentyl Caffeate Inclusion Complex: Synthesis, Characterization and Antileishmanial Activity

et al. 2020

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“…Essential oils are good candidates for insecticides, however, their terpenes have low solubility in aqueous media, which represents the first stage of development of culicids such as A. aegypti , and are subject to degradation by oxidation and volatility [40]. To improve the solubility of essential oils in water, nano-emulsions were developed by the low energy method using phase inversion composition.…”

Section: Resultsmentioning

confidence: 99%

Development of nano-emulsions based onAyapana triplinervisfor the control ofAedes aegyptilarvae

Rodrigues

Lopes

Rabelo

et al. 2020

Preprint

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AbstractAyapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study is to evaluate the larvicidal activity against A. aegypti of nano-emulsions containing essential oils from A. triplinervis morphotypes, and acute oral toxicity in non-target organism. Essential oils were identified and nano-emulsions were prepared using the low energy method. The mortality test of A. aegypti larvae was performed according to the protocol recommended by the World Health Organization, and toxicity in non-target mammals was performed according to the OECD. Phytochemical analyses indicated the major compounds (E)-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A, and in morphotype B, Thymohydroquinone Dimethyl Ether (84.53%) was found. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (PdI = 0.124 ± 0.009 and ZP = −19,300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (PdI = 0.168 ± 0.016 and ZP = −27,700 ± 1,307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae and safe for non-target mammals.

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“…In addition to DF, Ae. aegypti is also a competent vector of many other arbovirus diseases, such as chikungunya fever, yellow fever and Rift Valley fever . Adequate management of Ae.…”

Section: Introductionmentioning

confidence: 99%

Modelling the potential distribution of arbovirus vector Aedes aegypti under current and future climate scenarios in Taiwan, China

Liu

Jiao

et al. 2019

Pest Management Science

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BACKGROUND: Aedes aegypti is one of the most important mosquito species and is a common disease-transmitting pest in tropical areas. Various infectious arbovirus diseases can be transmitted by Ae. aegypti. With ongoing global climate change, we are facing an increasing public health threat from the rapid spread of disease vectors into wider geographical areas. To better understand the current ecological niche range and possible future expansion of Ae. aegypti, an ecological niche modelling approach was adopted to predict its current and future potential habitat in Taiwan, China. 30 arcsec (approx. 1 × 1 km) were made by our model. Ae. aegypti was predicted to expand its habitat in varying degrees out of its current niche range under different climate scenarios for the future 21st century. Winter temperature and dry season precipitation were considered as important predictors among climate variables. Croplands, pasture, forested lands and urban lands were important land-use variables. RESULTS: Based on observed occurrence records and environmental layers reflecting climate and land-use conditions, predictions with a high resolution of CONCLUSION:Ae. aegypti is expected to establish new habitats out of its current niche range under the trend of global climate change. The extent of habitat expansion varies under different climate scenarios. Appropriate measures should be taken to prevent its expansion to a broader scale. Our study has important strategic implications for mosquito surveillance and the prevention and control of mosquito-borne diseases.

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Lippia gracilis essential oil in β‐cyclodextrin inclusion complexes: an environmentally safe formulation to control Aedes aegypti larvae

Abstract: The inclusion complex with LGEO was a feasible formulation, being economically viable, easy-to-apply and without impact on non-target organisms and, therefore, is a potential alternative larvicide for Ae. aegypti control. © 2018 Society of Chemical Industry.

Cited by 21 publications

References 30 publications

β-Cyclodextrin/Isopentyl Caffeate Inclusion Complex: Synthesis, Characterization and Antileishmanial Activity

β-Cyclodextrin/Isopentyl Caffeate Inclusion Complex: Synthesis, Characterization and Antileishmanial Activity

Development of nano-emulsions based onAyapana triplinervisfor the control ofAedes aegyptilarvae

Modelling the potential distribution of arbovirus vector Aedes aegypti under current and future climate scenarios in Taiwan, China

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