<i>Maerua angolensis</i> DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole‐Induced Oxidative Stress and Seizures in Rats

Benneh, Charles Kwaku; Biney, Robert Peter; Tandoh, Augustine; Ampadu, Felix Agyei; Adongo, Donatus Wewura; Jato, Jonathan; Woode, Eric

doi:10.1155/2018/9684138

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…Brain superoxide dismutase activity was measured as described by Misra and Fridovich (1972) and Benneh et al (2018) . Briefly, 0.75 ml of ethanol (96% v/v) and 0.15 ml of chilled chloroform were added to 0.5 ml of tissue homogenate and centrifuged at 2,000 × g for 20 min at 30 C to obtain a clear supernatant.…”

Section: Methodsmentioning

confidence: 99%

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

et al. 2021

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Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the in vitro and in vivo models of epilepsy to probe the anticonvulsant potentials of essential oil from M. officinalis (MO) to gain insight into the scientific basis for its applications in traditional medicine for the management of convulsive disorders. MO was evaluated for effects on maximal electroshock (MES) and pentylenetetrazole (PTZ) -induced seizures in mice, on 4–aminopyridine (4-AP)-brain slice model of epilepsy and sustained repetitive firing of current clamped neurons; and its ameliorative effects were examined on seizure severity, anxiety, depression, cognitive dysfunction, oxidative stress and neuronal cell loss in PTZ-kindled rats. MO reversibly blocked spontaneous ictal-like discharges in the 4-AP-brain slice model of epilepsy and secondary spikes from sustained repetitive firing, suggesting anticonvulsant effects and voltage-gated sodium channel blockade. MO protected mice from PTZ– and MES–induced seizures and mortality, and ameliorated seizure severity, fear-avoidance, depressive-like behavior, cognitive deficits, oxidative stress and neuronal cell loss in PTZ–kindled rats. The findings warrant further study for the potential use of MO and/or its constituent(s) as adjunctive therapy for epileptic patients.

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Section: Methodsmentioning

confidence: 99%

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

et al. 2021

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“…Maerua angolensis extract was obtained according to methods described by Benneh and colleagues [ 13 , 14 ]. The concentrate obtained was further dried in a hot air oven at 55°C for 72 h to obtain a green semisolid mass (~8.5 g) which was then stored in the freezer at -40°C until use.…”

Section: Methodsmentioning

confidence: 99%

Anxiolytic and Antidepressant Effects ofMaerua angolensisDC. Stem Bark Extract in Mice

Benneh

Biney

Adongo

et al. 2018

Depression Research and Treatment

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Introduction The stem bark extract of Maerua angolensis DC. (Capparaceae) is used as a traditional remedy for management of anxiety, psychosis, and epilepsy. Aim of the Study We therefore aimed at evaluating the anxiolytic and antidepressant potential of the plant in mice models. Methods The dried stem bark was extracted with petroleum ether/ethyl acetate (50:50) mixture to obtain the extract, MAE. We employed Irwin's test to identify the preliminary behavioral and autonomic effects. Subsequently, MAE was administered per os to male mice and subsequently assessed, 1 h later, for anxiety parameters in the elevated plus maze (EPM) and the regular Suok tests. The forced swim (FST) and tail suspension (TST) tests were employed to assess the antidepressant potential of the extract (100-1000 mg kg−1). Results In our preliminary assay, MAE (100-5000 mg/kg) exhibited analgesic effects and a reduction in fear response in the Irwin's test. The spontaneous locomotor activity was reduced at 1000 mg/kg. Additionally, MAE (1000 mg/kg) increased the latency to PTZ-induced convulsions, and duration to sleep in the pentobarbitone induced sleeping time assay. MAE (1000 mg/kg), similar to diazepam, in the anxiolytic assay, increased the percentage time spent in the open arms while decreasing protected head dips and unprotected stretch attend postures in the EPM. Correspondingly, there was a reduction in anxiety-induced immobility and freezing in the Suok test (300 mg/kg) without loss of sensorimotor coordination. Additionally, there was a significant reduction in immobility duration in the FST (300 mg/kg) and TST (1000 mg/kg). Conclusion The petroleum ether/ethyl acetate fractions of Maerua angolensis stem bark possess anxiolytic and acute antidepressant effects in mice.

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“…The extract reduced the mean number of head-dips in the exploratory test, shortened the onset and prolonged the duration of diazepam induced sleep at the dosage of 800.0 mg/kg [63]. Benneh et al [72] evaluated the anticonvulsant activities of petroleum ether: ethyl acetate (50:50) extract of M. angolensis stem bark at doses ranging from 100.0 mg/kg to 1000.0 mg/kg were administered per os to male Sprague-Dawley rats after pre-treatment with flumazenil (0.3 mg/kg) or L-arginine (150.0 mg/kg) or sildenafil (5.0 mg/kg1) and subcutaneous injection of pentylenetetrazole (65.0 mg/kg). The extract exhibited antiseizure activities by affecting the GABAergic and nitric oxide-cGMP pathways [72].…”

Section: Anticonvulsant Activitiesmentioning

confidence: 99%

Maerua angolensis DC. (Capparaceae): A Review of its Medicinal Uses, Phytochemistry and Pharmacological Properties

Maroyi

2020

J. Pharm. Nutr. Sci.

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Maerua angolensis DC. is collected from the wild for its edible leaves and fruits, and is also used as a traditional medicine. This study is aimed at evaluating the ethnomedicinal uses, phytochemistry and pharmacological properties of M. angolensis. Results of the current study are based on data derived from several online databases such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, books, dissertations, book chapters and journal articles. The articles published between 1960 and 2020 were used in this study. This study revealed that the aerial parts, bark, leaves, roots and stem bark infusion and/or decoction of M. angolensis are mainly used as a protective charm and ethnoveterinary medicine, and a traditional medicine for pain, cancer, fever, malaria, sores, wounds and gastro-intestinal problems. Phytochemical compounds identified from the species include alkaloids, amino acids, anthraquinones, betaines, cardiac glycosides, cyanidin, esters, fatty acids, flavonoids, glucosinolates, phenols, saponins, sterols, steroids, tannins and triperpenoids. Ethnopharmacological research revealed that M. angolensis extracts have acaricidal, anthelmintic, antibacterial, antifungal, antidiarrhoeal, anticonvulsant, anti-diabetic, antidepressant, anti-inflammatory, antioxidant, antinociceptive, anxiolytic, anti-urolithiatic, antiprotozoal, molluscicidal and nematicidal activities. There is need for extensive toxicological evaluations of crude extracts and compounds isolated from the species since M. angolensis contains potentially toxic compounds

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Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole‐Induced Oxidative Stress and Seizures in Rats

Cited by 10 publications

References 32 publications

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

Anxiolytic and Antidepressant Effects ofMaerua angolensisDC. Stem Bark Extract in Mice

Maerua angolensis DC. (Capparaceae): A Review of its Medicinal Uses, Phytochemistry and Pharmacological Properties

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