<i>Malus toringoides</i>
            (Rehd.) Hughes improves glucose and lipid metabolism and liver injury in high fructose‐induced mice

Quan, Xianghua; Guo, Qie; Li, Xiangpeng; Yu, Liang; Cui, Mengna; Li, Jing; Huang, Shan; Wang, Jule; Li, Bin

doi:10.1111/jfbc.14134

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Rat diets were provided by XIETONG.ORGANISM Co., Ltd. Some studies found that the ethanol extract of plenty of plants has the function of treating hepatic steatosis (Abbas, Boby, Lee, Hong, & Park, 2022;Quan et al, 2022), but there is a lack of research on the treatment of obesity and liver steatosis with ethanol extract of Arctium lappa L root. Samples of 5 and 100 mg/kg•bw/day of ethanol extract of Arctium lappa L were used as the low monitoring dose and high monitoring dose respectively for the experiment.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK / ACC / CPT ‐1 pathway

Sheng

Gao

et al. 2022

Journal of Food Biochemistry

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Burdock (Arctium lappa L) root is eaten as a vegetable in many countries and used as an ethnomedicine because of its various pharmacological effects. The objective of this study was to investigate the underlying mechanisms of ethanolic extract of root from Arctium lappa L root (ALE) to lose weight and regulate lipid metabolism. The results showed that ALE can regulate lipid metabolism level and inhibit the weight gain of rats induced by the high‐sugar and high‐fat diet. The contents of triglyceride and cholesterol in the liver of obese rats significantly reduced, and hepatic steatosis was ameliorated. In addition, this study identified that ALE enhanced hepatic fatty acid β‐oxidation and ameliorated hepatic steatosis by activating AMPK/ACC/CPT‐1 pathway. These results indicated that ALE has a potential preventive and therapeutic effect on metabolic‐associated fatty liver disease and obesity. Practical Applications Obesity is already a global health problem. Obesity causes accumulation of triglycerides, which leads to hepatic steatosis. Long‐term steatosis causes liver damage and metabolic fatty liver disease. Plant‐derived functional foods or herbal medicines have better effects on weight loss and liver protection, which are more conducive to long‐term use with less toxic side effects. As a medicinal and edible plant material, Arctium lappa L root has the effect in losing weight. Our study showed that ethanolic extract of Arctium lappa L root effectively regulates lipid metabolism and inhibits hepatic steatosis. Arctium lappa L root may be used as a therapeutic drug and functional food raw material for obesity and fatty liver disease.

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Section: Animals and Experimental Designmentioning

confidence: 99%

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK / ACC / CPT ‐1 pathway

Sheng

Gao

et al. 2022

Journal of Food Biochemistry

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“…Histological examination was assessed by using haematoxylin and eosin staining (Quan et al, 2022). After the mice were sacrificed by cervical dislocation, the brain tissues and liver tissues harvested.…”

Section: Histological Examinationmentioning

confidence: 99%

Protective effects of Dendrobium huoshanense polysaccharide on D‐gal induced PC12 cells and aging mice, in vitro and in vivo studies

Liu

Deng

et al. 2022

Journal of Food Biochemistry

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Dendrobium huoshanense C. Z. Tang et S. J. Cheng polysaccharide (DHP) is the essential active ingredient of D.huoshanense and has high medicinal value. A high dose of D‐galactose (D‐gal) is commonly utilized in the aging model establishment. In this study, we explored whether DHP shields PC12 cells and aging mice from D‐gal caused damage and the possible mechanism. In vitro experiments, D‐gal induced PC12 cells were used to investigate, and then DHP was used for treatment. In vivo experiments, 72 SPF ICR male mice were randomly divided into six groups (control: normal saline; model: D‐gal (400 mg/kg); VE group: VE (50 μg/ml); DHP groups: D‐gal + DHP (15.6 mg/ml; 31.2 mg/ml; 62.4 mg/ml)). The results showed that DHP could enhance the viability of D‐gal injured PC12 cells and prevent cell apoptosis. DHP effectively promoted the transition from phase G0/G1 to phase S and inhibited cell cycle arrest. DHP has a potential neuroprotective effect on D‐gal caused cognitive and memory disorders in mice. On the one hand, DHP protects the antioxidant enzymes SOD, GSH‐PX, and CAT from excessive ROS buildup. On the other hand, DHP was demonstrated to block the expression of the P53/P21 signaling pathway‐related proteins P53, P21, and P16. These results imply that DHP could be a potential neuroprotective agent against aging. Practical applications Cognitive and memory decline caused by aging problems has become a problem in recent years. There are many theories about aging, among which oxidative stress is considered to be one of the important pathophysiological parts of various diseases in the aging process. In this study, DHP could not only improve the damage of D‐Gal to PC12 cells, but also improve the cognitive and memory impairment caused by D‐Gal in mice. In conclusion, this study verified the anti‐aging effect of DHP from in vitro and in vivo experiments, and its mechanism may involve the P53/P21 pathway. Therefore, this study indicated that polysaccharides from Dendrobium huoshanense, a traditional Chinese medicine of homologous medicine and food, had potential and industrial value as potential anti‐aging drugs.

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Berberine alleviates fructose-induced hepatic injury via ADK/AMPK/Nrf2 pathway: A novel insight

Cheng,

Yan,

Tan

et al. 2024

Biomedicine & Pharmacotherapy

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Malus toringoides (Rehd.) Hughes improves glucose and lipid metabolism and liver injury in high fructose‐induced mice

Cited by 4 publications

References 31 publications

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK / ACC / CPT ‐1 pathway

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK / ACC / CPT ‐1 pathway

Protective effects of Dendrobium huoshanense polysaccharide on D‐gal induced PC12 cells and aging mice, in vitro and in vivo studies

Berberine alleviates fructose-induced hepatic injury via ADK/AMPK/Nrf2 pathway: A novel insight

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