<i>Melissa officinalis</i> L. essential oil: antitumoral and antioxidant activities

Sousa, Allyne C. de; Alviano, Daniela Sales; Blank, Arie Fitzgerald; Alves, Péricles Barreto; Alviano, Celuta Sales; Gattass, Cerli Rocha

doi:10.1211/0022357023321

Cited by 182 publications

(131 citation statements)

References 25 publications

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“…Scientific studies have shown the role of essential oils in biological interactions among plants and their potential therapeutic including anti-inflammatory, analgesic, anti-tumor, antifungal, and antibacterial activities (Siani et al, 2000;Silva et al, 2003;Sousa et al, 2004;Osei-Safo et al, 2010;Kaileh et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antimicrobial and antioxidant potential of the essential oil of Guarea kunthiana A. Juss

et al. 2017

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The essential oils are extracted from plant compounds and can present activities antimicrobial and antioxidant properties. The goals of the present study were: (a) to determine the chemical composition of the essential oil of Guarea kunthiana A. Juss using the method of gas chromatography coupled to mass spectrometry (GC-MS); (b) to evaluate the antimicrobial potential of this oil using the broth microdilution method against different microorganisms: five Gram-negative bacteria, four Gram-positive bacteria and a yeast and (c) to determine the antioxidant activity of the oil using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical assay. The GC-MS analyses allowed identifying 13 constituents, representing 96.52% of the essencial oil composition. The main compounds identified were α-zingiberene (34.48%), β-sesquiphellandrene (22.90%), and α-curcumene (16.17%). With respect to the antimicrobial activity, the essential oil was effective against all the microorganisms tested, except for the bacteria E. coli and K. pneumoniae, which were resistant to the action of the oil. From a general point of view, Gram-positive bacteria were more susceptible to the action of the essential oil than Gram-negative bacteria. The essential oil exhibited antioxidant potential.Keywords: Guarea kunthiana, essential oil, chemical composition, antimicrobial activity, antioxidant. Composição química, potencial antimicrobiano e antioxidante do óleo essencial de Guarea kunthiana A. Juss ResumoOs óleos essenciais são compostos extraídos de plantas e podem apresentar propriedades antimicrobianas e antioxidantes. O objetivo deste trabalho foi (a) determinar a composição química do óleo essencial de Guarea kunthiana A. Juss pelo método de cromatografia gasosa acoplada à espectrometria de massas (CG-EM); (b) avaliar o potencial antimicrobiano deste óleo pelo método de microdiluição em caldo frente a diferentes micro-organismos, sendo cinco bactérias Gram-negativas, quatro Gram-positivas uma levedura e (c) por fim, determinar a atividade antioxidante do óleo pelo método de captura do radical livre 2,2-difenil-1-picril hidrazil (DPPH). As análises de CG-EM resultaram na identificação de 13 constituintes, representando 96,52% da composição do óleo essencial. Os principais compostos identificados foram α-Zingibereno (34,48%), β-Sesquifelandreno (22,90%) e α-Curcumeno (16,17%). Em relação à atividade antimicrobiana, o óleo essencial foi efetivo frente a todos os micro-organismos testados exceto para as bactérias E. coli e K. pneumoniae, as quais se apresentaram resistentes à ação do óleo. Em geral, as bactérias Gram-positivas foram mais suscetíveis à ação do óleo essencial em relação às Gram-negativas. O óleo essencial apresentou potencial.Palavras-chave: Guarea kunthiana, óleo essencial, composição química, atividade antimicrobiana, antioxidante.

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Section: Introductionmentioning

confidence: 99%

Chemical composition, antimicrobial and antioxidant potential of the essential oil of Guarea kunthiana A. Juss

et al. 2017

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“…Melissa officinalis is an aromatic plant of the Lamiaceae family. Its EO presents different biological activities including an antitumor activity that was described by de Souza and colleagues [15]. In this work, it was shown that the essential oil of the plant could inhibit the viability of cell lines from various types of cancer such as breast, lung, colon, melanoma and leukemia.…”

Section: Essential Oilsmentioning

confidence: 68%

“…However, although these cells include a number chemo resistant lines like lung (A540) and melanoma (B16F10) the mechanism of their death was not investigated. The study of the composition of this EO, by gas chromatography, showed that it has as major components neral (39.28%) and geranial (47.32%), which together represent almost 90% of the oil composition [15]. These two compounds are isomers of the same molecule, citral.…”

Section: Essential Oilsmentioning

confidence: 97%

Exploring Melissa Officinalis Properties for Glioblastoma Multiforme Treatment

Gattass¹

2015

Chemotherapy (Los Angel)

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“…La Melissa officinalis posee un efecto antiviral (Dimitrova et al, 1993;Allahverdiyev et al, 2004), además de poseer propiedades antibacterianas y antimicóticas (Mimica-Dukic et al, 2004), evaluando su efecto antitumoral, debido a sus componentes antioxidantes (de Sousa et al, 2004), así como su capacidad sedante (Sadraei et al, 2003).…”

Section: Introductionunclassified

Estudio Comparativo entre Terapia con Melissa officinalis vs. Tratamiento Convencional con Aciclovir Tópico al 5% para Lesiones Herpéticas Tipo 1

2014

Int. J. Odontostomat.

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entre terapia con Melissa officinalis vs. tratamiento convencional con aciclovir tópico al 5% para lesiones herpéticas tipo 1. Int. J. Odontostomat., 8(3):323-328, 2014. RESUMEN:El herpes simple tipo I es una patología infecciosa e inflamatoria de tipo vírico que se caracteriza por la aparición de lesiones ulcerativas extra orales, de duración aproximada de 14 días y que provocan gran picazón e incomodidad a las personas que lo padecen. El objetivo de este trabajo fue evaluar el uso la Melissa officinalis (toronjil) como terapia alternativa sobre el tiempo de remisión y el número de las lesiones extraorales en pacientes con herpes simple del comparado con el Aciclovir tópico al 5% como terapia convencional. Se realizó un ensayo clínico, aleatorizado y enmascarado simple, controlado. Se evaluó a 34 pacientes con lesiones herpéticas extra orales activas en la etapa primaria vesiculosa, sin patologías asociadas a alteraciones del sistema inmunológico como diabetes mellitus, alergias e hipertensión arterial. Se les administró el tratamiento tópico y se les evalúo diariamente las lesiones herpéticas. La Melissa officinalis posee un efecto antiviral sobre lesiones herpéticas tipo 1 al igual que el Aciclovir tópico al 5%, pero la Melissa officinalis es más efectivo en la disminución de días con lesiones herpéticas (valor p=0,05). La Melissa officinalis tiene un efecto antiviral positivo sobre lesiones herpéticas tipo 1, disminuyendo el número total de días con las lesiones herpéticas en comparación con el Aciclovir tópico al 5%.PALABRAS CLAVE: herpes simple tipo 1, patología viral, lesiones ulcerativas, Melissa officinalis, aciclovir tópico al 5%, antiviral.

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Melissa officinalis L. essential oil: antitumoral and antioxidant activities

Cited by 182 publications

References 25 publications

Chemical composition, antimicrobial and antioxidant potential of the essential oil of Guarea kunthiana A. Juss

Chemical composition, antimicrobial and antioxidant potential of the essential oil of Guarea kunthiana A. Juss

Exploring Melissa Officinalis Properties for Glioblastoma Multiforme Treatment

Estudio Comparativo entre Terapia con Melissa officinalis vs. Tratamiento Convencional con Aciclovir Tópico al 5% para Lesiones Herpéticas Tipo 1

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