<i>Mentha aquatica</i> L. aerial parts: <i>in vitro</i> anti-proliferative evaluation on human tumour and non-tumour cell lines

Souza, Lara; Tinti, Sirlene Valério; Sousa, Ilza Maria de Oliveira; Montanari, Ílio; Costa, José Luiz; Carvalho, João Ernesto de; Foglio, Mary Ann; Ruiz, Ana Lúcia Tasca Góis

doi:10.1080/14786419.2021.1937152

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…For all experiments, aliquots of each essential oil were diluted in DMSO (100 mg/mL) followed by serial dilution in complete medium affording the final concentrations of 0.15, 1.5, 15, 25, 50, and 150 µg/mL, depending on the experiment. As previously reported (Sobreiro et al 2023;de Souza et al 2022;da Silva et al 2020), final concentration of DMSO (≤ 0.15%) did not affect cell viability. Doxorubicin (0.015, 0.15, 1.5, and 15 µg/mL) was diluted in the same way.…”

Section: Sample Preparationsupporting

confidence: 83%

“…Using these curves, two effective concentrations representing the sample concentration required to promote 50% (GI50) and total (TGI) growth inhibition of each cell line was calculated by sigmoidal regression using Origin 8.0 software. (Monks et al 1991;de Souza et al 2022).…”

Section: Anti-proliferative Activity Assaymentioning

confidence: 99%

“…The protocol was according to the method described by Franken et al (2006) andde Souza et al (2022). After reaching 80% of confluence in T25 flasks, MCF-7 cells were treated with T. minuta EO (25 and 50 µg/mL) for 48 h. Untreated cells were considered as negative control.…”

Section: Clonogenic Assaymentioning

confidence: 99%

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Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadán, Región La Libertad, Perú

Meza

Vásquez-Kool

Sánchez

et al. 2023

Natural Product Research

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This study evaluated the chemical composition and anti-proliferative activity of essential oils (EOs) obtained by hydrodistillation from seven medicinal plants from Cachicadán, La Libertad Region, Peru. Limonene (0.64 to 44.43%) and linalool (0.36 to 2.12%) were identified in all EOs by gas chromatography coupled to mass spectrometry analysis. The major components (relative intensity ≥ 10%) were cisdihydro carvone, carvone, and cis-piperitone epoxide for Minthostachys mollis leaves; β-pinene, limonene, and ledol for Lepechinia heteromorpha leaves; limonene, neral, and geranial for Aloysia citriodora, both leaves and flowers; αpinene, and limonene for Myrcianthes myrsinoides leaves; and α-pinene, βmyrcene, and (E)-β-Ocimene for Dalea carthagenensis leaves. Constituted by (Z)β-ocimene, dihydrotagetone, (Z)-tagetone, and car-3-en-2-one, EO of Tagetes minuta leaves induced an irreversible cytostatic effect against MCF-7 human breast tumour cells. Further in vivo studies must be carried out to establish the safe and efficient dose of T. minuta EO as adjuvant treatment in oncological therapies.

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Section: Sample Preparationsupporting

confidence: 83%

Section: Anti-proliferative Activity Assaymentioning

confidence: 99%

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Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadán, Región La Libertad, Perú

Meza

Vásquez-Kool

Sánchez

et al. 2023

Natural Product Research

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“…The influence on cell growth of selected samples was evaluated following the protocol described by Monks et al [ 12 ] with adaptations [ 13 ]. In 96-well plates, CHO-K1 cells (4 × 10 4 cell mL −1 , 100 µL well −1 ) were exposed to each sample (0.25, 2.5, 25 and 250 µg mL −1 , final concentrations) for 4 and 48 h. In the 4 h exposure experiment, after the first 4 h, the medium was removed, and CHO-K1 cells were kept in fresh complete medium for 20 h. A T0 plate representing the cell density at the time of sample treatment was made (T0 untreated cells ).…”

Section: Methodsmentioning

confidence: 99%

Enzymatic Hydrolysis of Rutin: Evaluation of Kinetic Parameters and Anti-Proliferative, Mutagenic and Anti-Mutagenic Effects

Sobreiro

Torre

Araújo

et al. 2023

Life

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The bioavailability of glucoside flavonoids is influenced by the nature of the sugar, glucosides being absorbed faster than rhamnoglucosides, for example. One strategy to enhance the bioavailability is enzymatic hydrolysis. In this study, some kinetic parameters of hesperidinase-mediated hydrolysis of rutin were evaluated using an UHPLC/QTOF-MSE analysis of the products of a bioconversion reaction. The resulting hydrolyzed rutins (after 4, 8 and 12 h of reaction) were submitted to anti-proliferative and Cytokinesis-Block Micronucleus (CBMN) assays in CHO-K1 cells. In the hesperidinase-mediated hydrolysis, the final concentration of quercetin-3-O-glucoside (Q3G) was directly proportional to the rutin concentration and inversely proportional to the reaction time. At an anti-proliferative concentration (2.5 μg/mL), hydrolyzed rutin derivatives did not show a mutagenic effect, except for the sample with a higher content of Q3G (after 4 h of the enzymatic hydrolysis of rutin). Moreover, the higher Q3G content in hydrolyzed rutin protected the CHO-K1 cells 92% of the time against methyl methanesulfonate-induced mutagenic damage. These results suggested that the anti-mutagenic effect of hydrolyzed rutin might be related to antioxidant and cell death induction. Presenting a good lipophilicity/hydrophilicity ratio, together with antioxidant and anti-mutagenic activities, the hesperidinase-mediated hydrolyzed rutin seemed to be a promisor raw material for the development of food supplements.

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“…The results were plotted as cell growth versus sample concentration curves. Using these curves, one effective concentration representing the sample concentration required to promote 50% of growth inhibition (GI 50 ) of each cell line was calculated by sigmoidal regression 30,31 using Origin 8.0 software.…”

Section: Characterization Of Phenolic Fractionsmentioning

confidence: 99%

Capsicum chinense var. BRS Moema: chemical characterization by HPLC-ESI-MS/MS and antiproliferative screening

et al. 2023

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Mentha aquatica L. aerial parts: in vitro anti-proliferative evaluation on human tumour and non-tumour cell lines

Cited by 7 publications

References 41 publications

Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadán, Región La Libertad, Perú

Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadán, Región La Libertad, Perú

Enzymatic Hydrolysis of Rutin: Evaluation of Kinetic Parameters and Anti-Proliferative, Mutagenic and Anti-Mutagenic Effects

Capsicum chinense var. BRS Moema: chemical characterization by HPLC-ESI-MS/MS and antiproliferative screening

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