<i>miR‐125a‐5p</i> promotes gastric cancer growth and invasion by regulating the Hippo pathway

Li, Ruixin; Hu, Zhihao; Wang, Zhuoyin; Zhu, Tianyu; Wang, Guojun; Gao, Bu-Lang; Wang, Jingtao; Deng, Xiu-Mei

doi:10.1002/jcla.24078

Cited by 14 publications

(9 citation statements)

References 44 publications

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“…It has been confirmed that miR-125a-5p facilitates osteoclastogenesis via targeting TNFRSF1B ( 19 ). In gastric cancer, miR-125a-5p was found to promote gastric cancer cell growth and invasion by activating the Hippo pathway ( 20 ). We conducted the correlation analysis, expression analysis, and prognosis analysis.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study

et al. 2022

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Shugoshin-like protein 1 (SGO1) has been characterized in its function in correct cell division and its role in centrosome cohesion in the nucleus. However, the underlying biological function and potential mechanisms of SGO1 driving the progression of lung adenocarcinoma remain unclear. In this study, we found that SGO1 was increased in LUAD tissues and cell lines. Upregulation of SGO1 expression was correlated with poor overall survival (OS), disease-free survival (DSS), and progression-free survival (PFS) in patients with LUAD. ROC curve analysis suggested that the AUC value of SGO1 was 0.983. Correlation analysis showed that SGO1 expression was related to immune infiltration in LUAD. Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD. Finally, we determine that SGO1 regulated the cell proliferation and cell apoptosis of lung adenocarcinoma in vitro. In conclusion, our data suggested that SGO1 could be a novel prognostic biomarker for lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study

et al. 2022

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“…It has been shown that herpes simplex virus 1 infection can cause gastric cancer, and the Hippo signaling pathway is closely related to the in ltration and metastasis of gastric cancer. FBXW5 and miR-125a-5p promote the deterioration of gastric cancer cells by inactivating the Hippo signaling pathway [18][19][20][21]. People who are susceptible to H. pylori have a high probability of suffering from gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…According to the Global Cancer Statistics 2020 report, the number of new cancer cases is 19.29 million, the number of new deaths is expected to be 9.95 million and 28.4 million new cancer cases are expected in 2040, an increase of 47% from 2020, with gastric cancer ranking fth in global cancer incidence and fourth in cause of death [1]. The common treatments for gastric cancer include surgical resection and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics study of PCDHB6 as a prognostic marker for gastric cancer

Huang

Liang

Wei

et al. 2022

Preprint

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Background Gastric cancer is a common and fatal disease with the highest incidence and mortality in men. Protocadherin beta 6 (PCDHB6) has not been reported much in tumors and the role of PCDHB6 in gastric cancer is not yet clear. Therefore, we aimed to investigate the expression of PCDHB6 in gastric cancer infiltration, invasion and metastasis and to assess the prognostic and functional significance of PCDHB6 in gastric cancer. Methods Based on TCGA, GEO database, bioinformatics analysis of PCDHB6 gene was performed from gene expression, survival analysis, gene mutation, immune infiltration, DNA methylation and enrichment analysis. In addition, Real-Time PCR was used to further confirm the role of PCDHB6 in gastric cancer. Results PCDHB6 gene was highly expressed in gastric cancer and positively correlated with poor patient prognosis. Real-Time PCR results also showed high expression of PCDHB6 in gastric cancer. PCDHB6 expression was positively correlated with tumor-associated fibroblasts, Basophils, CD4 + memory T-cells, CD8 + T- cells, Eosinophils, Macrophages, Regulatory T-cells and Type 2 T-helper cells were positively correlated with immune infiltration. KEGG and GO enrichment analysis showed that PCDHB6 gene was mainly involved in the regulation of Herpes simplex virus 1 infection, Hippo signaling pathway and cell adhesion pathway. Conclusions Our study comprehensive summary and analysis revealed for the first time that PCDHB6 is highly expressed in gastric cancer and is an oncogene. PCDHB6 can be used as a potential prognostic biomarker for gastric cancer and provides a powerful therapeutic target for the treatment of gastric cancer.

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“…This miRNA from S. japonicum presents an identical seed sequence (2–8 nt in the 5′ region) to that of the human miRNA Hsa-miR-125a-5p. Interestingly, Hsa-miR-125a-5p may function as a powerful tumor promoter [ 121 ]. Thus, the miRNAs of helminths can share sequence similarities with human miRNAs and could show a similar capacity regarding the promotion or inhibition of tumor development.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Other mechanisms regulating gene expression, the availability of molecular targets, and the cellular context must be considered. For example, Hsa-miR-125a-5p can present oncogenic activity or tumor-suppressor functions in different types of cancer [ 121 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

Leija-Montoya

González-Ramírez

Martínez-Coronilla

et al. 2022

IJMS

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Infectious agents such as viruses, bacteria, and parasites can lead to cancer development. Infection with the helminthic parasite Schistosoma haematobium can cause cancer of the urinary bladder in humans, and infection with the parasites Clonorchis sinensis and Opisthorchis viverrini can promote cholangiocarcinoma. These three pathogens have been categorized as “group 1: carcinogenic to humans” by the International Agency for Research on Cancer (IARC). Additionally, the parasite Schistosoma japonicum has been associated with liver and colorectal cancer and classified as “group 2B: possibly carcinogenic to humans”. These parasites express regulatory non-coding RNAs as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which modulate genic expression in different biological processes. In this review, we discuss the potential roles of miRNAS and lncRNAs encoded by helminthic parasites that are classified by the IARC as carcinogenic and possibly carcinogenic to humans. The miRNAs of these parasites may be involved in carcinogenesis by modulating the biological functions of the pathogen and the host and by altering microenvironments prone to tumor growth. miRNAs were identified in different host fluids. Additionally, some miRNAs showed direct antitumoral effects. Together, these miRNAs show potential for use in future therapeutic and diagnostic applications. LncRNAs have been less studied in these parasites, and their biological effects in the parasite–host interaction are largely unknown.

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miR‐125a‐5p promotes gastric cancer growth and invasion by regulating the Hippo pathway

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 14 publications

References 44 publications

Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study

Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study

Bioinformatics study of PCDHB6 as a prognostic marker for gastric cancer

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

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