<i>miR‐181</i> as a putative biomarker for lymph‐node metastasis of oral squamous cell carcinoma

Yang, Cheng Chieh; Hung, Pei Shih; Wang, Pei Wen; Liu, Chung Ji; Chu, Ting; Cheng, Hui; Lin, Shu Chun

doi:10.1111/j.1600-0714.2010.01003.x

Cited by 122 publications

(84 citation statements)

References 30 publications

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“…To date, certain miRNAs have been suggested to play significant roles in OSCC development (9,(20)(21)(22)(23), which may function alone or in a cooperative manner for OSCC development. The overexpression of oncogenic miRNA may reduce the levels of the protein products of tumor-suppressor genes.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells

Yan

Lai

et al. 2012

Mol Med Report

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Abstract. microRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by either translational inhibition or mRNA degradation. miRNAs play pivotal roles in physiological functioning and pathological progression. The function of microRNA-99a (miR-99a) in oral squamous cell carcinoma (OSCC) remains unclear. In the present study, we investigated the roles of miR-99a in OSCC development and the underlying mechanisms in 25 cases of primary OSCC tissues and Tca-8113 cells. The cells were analyzed using FACS analysis and western blotting. Results showed that the expression levels of miR-99a were markedly decreased in OSCC tissues compared with the adjacent non-tumor tissues (n=25). The results of in vitro experiments showed that miR-99a mimics significantly inhibited the proliferation of Tca-8113 cells, a tongue squamous carcinoma cell line, and that miR-99a mimics markedly induced the apoptosis of Tca-8113 cells. Furthermore, we demonstrated that mammalian target of rapamycin (mTOR) was directly targeted by miR-99a, as the overexpression of miR-99a in Tca-8113 cells downregulated the protein expression level of mTOR. Thus, our findings suggest that the downregulation of miR-99a in OSCC tissues is associated with tumor development. miR-99a regulates the growth and survival of OSCC cells and may be exploited as a biomarker and therapeutic target for patients with OSCC.

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Section: Discussionmentioning

confidence: 99%

Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells

Yan

Lai

et al. 2012

Mol Med Report

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“…There was a weakly positive correlation between the tissue and serum levels of miR-544. The majority of previous studies have demonstrated the same trend of alteration between circulating miRNAs and tissue miRNAs, either an increase or decrease, in various types of cancer (24)(25)(26). However, a different correlation between circulating miRNAs and tissue miRNAs has also been observed.…”

Section: Discussionmentioning

confidence: 86%

Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma

Zhang

Wang

et al. 2012

Oncology Letters

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Abstract. Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a novel biomarker of malignant transformation. The expression of miR-544 was measured in a series of 198 glioma samples (63 low-grade glioma, 44 anaplastic astrocytoma and 91 glioblastoma tumors) using microarrays. Quantitative real-time reverse transcription PCR (qRT-PCR) was used to validate the expression levels of miR-544 in tissue and serum samples in an independent validated cohort (25 low-grade glioma, 21 anaplastic astrocytoma and 20 glioblastoma tumors). A Pearson correlation analysis was performed to examine the correlation between miR-544 levels of tissue and serum samples. Microarrays revealed that the expression levels of miR-544 decreased significantly in anaplastic gliomas (P<0.01) or glioblastoma (P<0.01) compared with low-grade gliomas. In an independent cohort of glioma patients, miR-544 exhibited a progression-associated downregulation in glioma tumors. The levels of miR-544 in serum samples tended to be lower in anaplastic and glioblastoma patients compared with low-grade gliomas, but with no significant difference. The Pearson correlation analysis revealed a weakly positive correlation between tissue and serum levels of miR-544. These data support a significant role for miR-544 aberration in the malignant transformation of glioma. The downregulation of miR-544 in tissue may be used as a novel biomarker.

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“…In addition, patients with higher levels of miR-181 were more likely to show lymph node metastasis, vascular invasion by tumor cells, and poor prognosis (Yang et al, 2011). As a member of the miR-181 family, miR-181b also may play a role in the variation in tumorigenesis among different cancers, and its decreased expression is inversely correlated with increased protein levels of the myeloid cell leukemia sequence 1-and B-cell lymphoma 2-targeted genes (Ji et al, 2009;Chen et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer

Li¹,

Xu²,

Wu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression between the signet-ring cell carcinoma and tubular adenocarcinoma subtypes of gastric cancer. Thirteen dysregulated miRNAs were identified in signet-ring cell carcinoma compared with tubular adenocarcinoma: miR-30a, miR-26b,

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miR‐181 as a putative biomarker for lymph‐node metastasis of oral squamous cell carcinoma

Abstract: miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC.

Cited by 122 publications

References 30 publications

Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells

Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells

Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma

Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer

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