miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk

Abstract

Wilms tumor (WT) is the most prevalent urologic malignancy in childhood. Nonetheless, the genetic factors underlying WT remain largely unknown. The miR-423 rs6505162 C>A polymorphism is associated with the susceptibility to numerous cancers; however, no investigations have been conducted on its association with WT. To evaluate the correlation between the miR-423 rs6505162 C>A polymorphism and WT risk in Chinese children, we genotyped this polymorphism using the Taqman method in 145 cases and 531 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the association. The results showed that the rs6505162 CA genotype was associated with decreased susceptibility to WT (CA versus CC: adjusted OR=0.65, 95% CI=0.42-0.99, P=0.047). In the stratified analysis, we found that CA/AA genotypes conferred a significantly decreased overall risk of WT in children younger than 18 months (adjusted OR=0.30, 95% CI=0.14-0.63, P=0.002) and those with clinical stage I+II WT (adjusted OR=0.42, 95% CI=0.20-0.85, P=0.017) when compared with CC genotype. In summary, the miR-423 rs6505162 C>A polymorphism may negatively modify WT susceptibility in Chinese children. Our findings should be validated in larger studies involving other ethnicities.

Functional mechanism and clinical implications of MicroRNA‐423 in human cancers

“…Similarly, rs6505162 has been identified as a biomarker of colorectal cancer metastasis 118 . Another study indicated that rs6505162 has a negative impact on susceptibility to Wilms tumor, especially in Chinese children 28 . However, no significant associations were found in some cancers, such as bladder cancer, 103 HCC, 119 and gastric cancer/advanced gastric cancer 120,121 .…”

“…[23][24][25] Previous studies have confirmed the differential expression of miR-423 in various human tumors, 26 and also indicated differences in the functional mechanisms in different tumor types. 27,28 In this article, we briefly review the latest reports on the functional mechanisms of miR-423 in tumors and its involvement in signaling pathways. The potential value of single nucleotide polymorphisms (SNPs) in pre-miR-423 (rs6505162) as a diagnostic biomarker, and a therapeutic target, are also discussed.…”

“…Two mature sequences (namely miR‐423‐3p and miR‐423‐5p ) of the miRNA‐423 gene were identified by searching the miRBase sequences 23‐25 . Previous studies have confirmed the differential expression of miR‐423 in various human tumors, 26 and also indicated differences in the functional mechanisms in different tumor types 27,28 . In this article, we briefly review the latest reports on the functional mechanisms of miR‐423 in tumors and its involvement in signaling pathways.…”

Investigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility

“…A total of 145 histopathologically confirmed cases of WT from Guangdong province (Southern China) were included in our study, [15][16][17][18][19][20][21] along with 531 unrelated, age-, gender-, and race-matched cancer-free controls. [22][23][24] Both imaging and pathological examination were used to diagnose the disease.…”

H19 gene polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study

“…Matthew K Iyer et al found many lncRNAs overlapping disease-associated SNPs [24]. Previous genomics studies have demonstrated that SNPs in several genes are associated with the risk of Wilms tumor [25][26][27]. It has been reported that H19 rs2839698 G>A, rs3024270 C>G or rs217727 G>A polymorphism is not associated with neuroblastoma susceptibility in the whole study population, while in strati ed analysis, girls with rs3024270 GG genotype had an increased risk of neuroblastoma [28].…”