<i>Momordica charantia</i>Maintains Normal Glucose Levels and Lipid Profiles and Prevents Oxidative Stress in Diabetic Rats Subjected to Chronic Sucrose Load

Chaturvedi, Padmaja; George, Santosh

doi:10.1089/jmf.2009.0151

Cited by 42 publications

(29 citation statements)

References 43 publications

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“…Administration of alcoholic extract of whole fruit powder to alloxan diabetic albino rats has been shown to result in decreases in blood sugar and improvements in the islets of Langerhans (Singh et al, 2008). Administration of fruit extract to sucrose-loaded alloxan diabetic rats normalized glucose levels and reduced triglyceride and low-density lipoprotein levels while increasing high-density lipoprotein levels and prevented oxidative stress, indicating a beneficial effect both on diabetes and reduced chances of diabetes leading to cardiovascular disorders (Chaturvedi and George, 2010). Antidiabetic effect of fruit extract has also been reported for insulin-resistant db/db mice (Klomann et al, 2010).…”

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confidence: 86%

Medicinal plants used for treatment of diabetes by the marakh sect of the Garo tribe living in Mymensingh district, Bangladesh

Rahmatullah

Azam

Khatun

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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Diabetes mellitus is an endocrinological disorder arising from insulin deficiency or due to ineffectiveness of the insulin produced by the body. This results in high blood glucose and with time, to neurological, cardiovascular, retinal and renal complications. It is a debilitating disease and affects the population of every country of the world. Around 200 million people of the world suffer from this disease and this figure is projected to rise to 300 million in the coming years. The disease cannot be cured with allopathic medicine as the drugs used do not restore normal glucose homeostasis and moreover have side-effects. On the other hand, traditional medicinal practitioners of various countries claim to cure diabetes or at least alleviate the major symptoms and progression of this disease through administration of medicinal plants. The Garos are an indigenous community of Bangladesh, who still follow their traditional medicinal practices. Their traditional medicinal formulations contain a number of plants, which they claim to be active antidiabetic agents. Since observation of indigenous practices have led to discovery of many modern drugs, it was the objective of the present study to conduct a survey among the Marakh sect of the Garos residing in Mymensingh district of Bangladesh to find out the medicinal plants that they use for treatment of diabetes. It was found that the tribal practitioners of the Marakh sect of the Garos use twelve medicinal plants for treatment of diabetes. These plants were

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confidence: 86%

Medicinal plants used for treatment of diabetes by the marakh sect of the Garo tribe living in Mymensingh district, Bangladesh

Rahmatullah

Azam

Khatun

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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“…Their results show that MC maintains the normal glucose levels, decreases triglyceride as well as low-density lipoprotein levels, and enhances high-density lipoprotein levels. MC also improves the anti-oxidant enzyme status by reducing TBARS levels and normalizing reduced glutathione levels [99] . Teoh et al have studied the protective effect of the MC extract on the kidneys of streptozotocin- induced diabetic Sprague-Dawley rats.…”

Section: Introductionmentioning

confidence: 99%

Bitter melon: a panacea for inflammation and cancer

Dandawate

Subramaniam

Padhyé³

et al. 2016

Chinese Journal of Natural Medicines

115

123

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Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds (Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q–U, Charantin, α-eleostearic acid) and proteins (α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.

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“…Primary human preadipocytes incubated with and without a Bitter Melon extract exhibited a strong potential to inhibit lipogenesis and stimulate lipolysis in-vitro [37]. In diabetic rats Bitter Melon maintains normal glucose levels and lipid profiles when the rats where subjected to chronic sucrose load [40]. As shown in C57BL/6 female mice Bitter Melon extract attenuates high fat diet associated with oxidative stress and neuroinflammation by normalization the activity of pro-inflammatory cytokines and glial cell activation markers in the brain [39].…”

Section: Preclinical Data For the Mode Of Ac-tion Of Bitter Melonmentioning

confidence: 92%

Personalized Diabetes and Cancer Medicine: A Rationale for Anti-Diabetic Nutrition (Bitter Melon) in a Supportive Setting

Zänker¹,

Mang²,

Wolters³

et al. 2012

CCTR

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Recent discoveries in epidemiology and molecular epidemiology suggest a link between cancer risk, cancer progression and diabetes risk factors and treatment. Obesity, physical inactivity, smoking, mal nutrition and age are common risk nominators for both diseases. Furthermore due to these risk factors, tumor patients are often comorbid with diabetes type 2. Therefore, it is an urgent need in order to meet at least one risk factor -obesity and mal nutrition -to show that -in a scientifically well-based manner -ethnopharmacology can provide views on plants with health informations. Apart from epidemiological evidence, selected botanicals have to be proven in preclinical and cellular settings, in animal studies for the proof of principle and in clinical trials for their potentials as dietary nutritional care. We have shown here for the first time according to this scientific sequencing of evaluation that a special water soluble Bitter Melon powder is a first candidate to be included into personalized diabetes type 2 and antitumor protocols as dietary supportive care to control the carbohydrate metabolism. The proof of principle to decrease blood glucose values in db/db mice by a Bitter Melon powder was demonstrated and a prospective, randomized, double-blinded and Placebo-controlled trial in diabetes type 2 patients, although continuously throughout the trial under conventional oral therapy, gave evidence for a Bitter Melon powder to be able to decrease HbA1c in a four-months intervention. This study highlights the importance of a significantly evaluated botanical as supportive diet care in tumor and diabetes type 2 patients.

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Momordica charantiaMaintains Normal Glucose Levels and Lipid Profiles and Prevents Oxidative Stress in Diabetic Rats Subjected to Chronic Sucrose Load

Cited by 42 publications

References 43 publications

Medicinal plants used for treatment of diabetes by the marakh sect of the Garo tribe living in Mymensingh district, Bangladesh

Medicinal plants used for treatment of diabetes by the marakh sect of the Garo tribe living in Mymensingh district, Bangladesh

Bitter melon: a panacea for inflammation and cancer

Personalized Diabetes and Cancer Medicine: A Rationale for Anti-Diabetic Nutrition (Bitter Melon) in a Supportive Setting

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