<i>Moringa oleifera</i> Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats

Randriamboavonjy, Joseph Iharinjaka; Heurtebise, Sandrine; Pacaud, Pierre; Loirand, Gervaise; Tesse, Angela

doi:10.1155/2019/2567198

Cited by 10 publications

(17 citation statements)

References 40 publications

(50 reference statements)

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“…Isorhamnetin also showed protective effects on endothelial cell line EA.hy926 and caused upregulation of eNOS expression 118 . Further, Quercetrin affected endothelial NO ⋅ signaling by inhibiting both arginase-1 activity and expression 119 .…”

Section: Discussionmentioning

confidence: 96%

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

Ibrahim

El–Mezayen

El‐Banna

2022

Sci Rep

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Liver cirrhosis is a late-stage liver disease characterized by excessive fibrous deposition triggering portal-hypertension (PH); the prime restrainer for cirrhosis-related complications. Remedies that can dually oppose hepatic fibrosis and lower PH, may prevent progression into decompensated-cirrhosis. Different Astragalus-species members have shown antifibrotic and diuretic actions with possible subsequent PH reduction. However, A.spinosus and A.trigonus were poorly tested for eliciting these actions. Herein, A.spinosus and A.trigonus roots and aerial parts extracts were subjected to comprehensive metabolic-fingerprinting using UHPLC-MS/MS resulting in 56 identified phytoconstituents, followed by chemometric untargeted analysis that revealed variable metabolic profiles exemplified by different species and organ types. Consequently, tested extracts were in-vivo evaluated for potential antifibrotic/anticirrhotic activity by assessing specific markers. The mechanistic prospective to induce diuresis was investigated by analyzing plasma aldosterone and renal-transporters gene-expression. Serum apelin and dimethylarginine-dimethylaminohydrolase-1 were measured to indicate the overall effect on PH. All extracts amended cirrhosis and PH to varying extents and induced diuresis via different mechanisms. Further, An OPLS model was built to generate a comprehensive metabolic-profiling of A.spinosus and A.trigonus secondary-metabolites providing a chemical-based evidence for their efficacious consistency. In conclusion, A.spinosus and A.trigonus organs comprised myriad pharmacologically-active constituents that act synergistically to ameliorate cirrhosis and associated PH.

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Section: Discussionmentioning

confidence: 96%

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

Ibrahim

El–Mezayen

El‐Banna

2022

Sci Rep

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“…A study revealed that administration of MO seed powder in a 750 mg/kg/day dose for 4 weeks gave protective effects to the endothelium function of aged rats. It was suggested that MO improved endothelium relaxation by increasing Akt signaling, activating endothelial NO synthase and down-regulating arginase-1 ( Randriamboavonjy et al, 2019 ). Phytochemical analysis was not performed in this study, but the endothelium improvement effects were most likely due to polyphenol, glucosinolate, and isothiocyanate compounds contained in MO.…”

Section: Role Of Mo In Cardiovascular Diseasesmentioning

confidence: 99%

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

et al. 2022

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Cardiac damage and vascular dysfunction due to underlying diseases, such as hypertension and cardiac thrombosis, or side effects from certain drugs may lead to critical illness conditions and even death. The phytochemical compounds in natural products are being prospected to protect the heart and vascular system from further damage. Moringa genus is a subtropical tree native to Asia and Africa, which includes 13 species; Moringa oleifera Lam. (MO) is the most cultivated for its beneficial uses. MO is also known as the “miracle tree” because it has been used traditionally as a food source and medicine to treat various diseases such as anemia, diabetes, and infectious or cardiovascular diseases. The phytochemical compounds identified in MO with functional activities associated with cardiovascular diseases are N,α-L-rhamnopyranosyl vincosamide, isoquercetin, quercetin, quercetrin, and isothiocyanate. This study aims to investigate the potency of the phytochemical compounds in MO as a protective agent to cardiac damage and vascular dysfunction in the cardiovascular disease model. This is a scoping review by studying publications from the reputed database that assessed the functional activities of MO, which contribute to the improvement of cardiac and vascular dysfunctions. Studies show that the phytochemical compounds, for example, N,α-L-rhamnopyranosyl vincosamide and quercetin, have the molecular function of antioxidant, anti-inflammation, and anti-apoptosis. These lead to improving cardiac contractility and protecting cardiac structural integrity from damage. These compounds also act as natural vasorelaxants and endothelium protective agents. Most of the studies were conducted on in vivo studies; therefore, further studies should be applied in a clinical setting.

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“…Endothelial dysfunction is a condition that precedes the development of atherosclerosis and CVD [ 38 ]. Endothelial dysfunction is characterized by reduced bioavailability of NO, an important vasodilator molecule produced by endothelial cells [ 35 ]. Typically, reduction in NO bioavailability is associated with increased production of reactive oxygen species and abnormal inflammatory response [ 3 , 27 , 32 , 57 ].…”

Section: Vascular Effectmentioning

confidence: 99%

“…The effects of Moringa supplementation on aging-associated endothelial dysfunction have been evaluated in rats [ 35 ]. This study [ 35 ] demonstrated a reduction in endothelium-dependent relaxation of arteries in aged rats compared to young/adult rats. However, an improvement of such parameters was returned after Moringa supplementation in aged rats.…”

Section: Vascular Effectmentioning

confidence: 99%

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

et al. 2022

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Polyphenols-rich food has been utilized to induce a positive effect on human health. Considering that fruit and vegetable by-products (seeds, pomace, and peels) are sources of polyphenols, previous studies have investigated the effect of dietary supplementation with food by-products on cardiometabolic disorders, such as high fasting blood glucose, dyslipidemia, and obesity. Endothelial dysfunction has also been considered a cardiometabolic parameter, given that it precedes cardiovascular disease. However, there is a scarcity of narrative reviews reporting the effect of food by-product supplementation on cardiometabolic disorders in animal and human clinical trials. In this sense, the present narrative review aims to investigate the impact of fruit and vegetable by-product supplementation on cardiometabolic disorders in humans and animals, exploring the possible mechanisms whenever possible. Research articles were retrieved based on a search of the following databases: PubMed, ScienceDirect, and Google Scholar using the following keywords and synonyms combined: (“fruit by-products” or “food waste” or “pomace” or “bagasse” or “seeds” or “waste products”) AND (“heart disease risk factors” or “endothelial dysfunction” or “atherosclerosis”). It was shown that fruit and vegetable by-products could efficiently improve cardiometabolic disorders in patients with chronic diseases, including hypertension, type II diabetes mellitus, and dyslipidemia. Such effects can be induced by the polyphenols present in food by-products. In conclusion, food by-product supplementation has a positive effect on cardiometabolic disorders. However, further studies investigating the effect of food by-products on cardiometabolic disorders in humans are still necessary so that solid conclusions can be drawn.

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Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats

Cited by 10 publications

References 40 publications

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

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