<i>Mycobacterium heckeshornense</i>
            Infection in an Immunocompetent Patient and Identification by 16S rRNA Sequence Analysis of Culture Material and a Histopathology Tissue Specimen

Hest, Reinier M. van; Zanden, Adri van der; Boeree, Martin J.; Kremer, Kristin; Dessens, Mirjam; Westenend, Pieter J.; Maraha, B.; Uffelen, Rene van; Schutte, Ronald; Lange, Wiel de

doi:10.1128/jcm.42.9.4386-4389.2004

Cited by 19 publications

(16 citation statements)

References 16 publications

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“…There were three case reports of pulmonary disease and one case of tenosynovitis, lymphadenitis and lumbar spondylodiskitis (2)(3)(4)(5)(6). M. heckeshornense is a scotochromogenic and slowly growing organism, having similar properties to Mycobacterium xenopi.…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium heckeshornense Lung Infection that was Diagnosed as Mycobacterium xenopi Disease by DNA-DNA Hybridization (DDH)

et al. 2011

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The DNA sequencing analyses of the 16S rRNA gene, rpoB and hsp65 were conducted to characterize six strains that had been identified as Mycobacterium xenopi by DNA-DNA hybridization (DDH) for past ten years in our hospital. The results revealed Mycobacterium heckeshornense infection in one of the six cases. A 47-year-old man, who had been treated for pneumonia, had pulmonary nontuberculous mycobacterial disease. The sputa from the patient were culture positive for mycobacterium in three times. And it was diagnosed as M. xenopi by DDH method. Chest X-ray showed fibrocavitary lesion in right upper lobe was successfully treated with clarithromycin for four weeks.

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Section: Introductionmentioning

confidence: 99%

Mycobacterium heckeshornense Lung Infection that was Diagnosed as Mycobacterium xenopi Disease by DNA-DNA Hybridization (DDH)

et al. 2011

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“…It is phenotypically very similar to M. xenopi; therefore, the burden of human disease caused by M. heckeshornense may have been underestimated in the past due to misidentification of M. heckeshornense as M. xenopi (3). It has since been described as a cause of lung disease in other patients (6,7,12) and as a cause of tenosynovitis (3). After a search of the published literature, we find this case is the first report of M. heckeshornense as a cause of lymphadenitis.…”

Section: Case Reportmentioning

confidence: 99%

First Case of Mycobacterium heckeshornense Lymphadenitis

et al. 2009

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Mycobacterium heckeshornense is a slow-growing nontuberculous mycobacterium first characterized in 2000. It is reported to cause lung disease and tenosynovitis. We report a case of isolated massive axillary lymphadenopathy in an elderly woman, where histology showed necrotizing granulomata and M. heckeshornense was isolated as the causative organism. CASE REPORTAn 84-year-old woman presented to her general practitioner in November 2006 with fatigue and subjective weight loss over several months and a mass in her left axilla. The mass had been progressively enlarging since she first noticed it several weeks earlier. Her doctor attempted to aspirate the mass, and the procedure was complicated by significant blood loss after the patient returned home. She developed palpitations and lightheadedness, which led to her admission to Middlemore Hospital.The patient had a history of treated hypertension and a squamous cell carcinoma of the left side of the neck which had been resected in 2005. Physical examination at the time of presentation to the emergency department revealed pallor and postural hypotension, as well as a large palpable mass in the left axilla. Bleeding from the attempted aspiration site had resolved spontaneously. Investigations showed that her electrolytes, creatinine, and liver function tests were normal. A full blood count revealed normochromic, normocytic anemia with a hemoglobin level of 82 g/liter and thrombocytopenia with a platelet count of 65 ϫ 10 9 /liter. Iron studies were consistent with anemia due to chronic disease. Computed tomography of the neck, chest, abdomen, and pelvis revealed enlarged left axillary lymph nodes up to 6 cm in diameter but no other lymphadenopathy and no lung pathology. A fine-needle aspirate of the left axillary lymph nodes was performed. Cytology showed only atypical lymphoid cells, and flow cytometry suggested a reactive lymphoid population within the sample.The patient proceeded to formal left axillary node dissection in December 2006. The operative findings were of two large nodes which appeared infected and were described as "possible cold abscesses." One of the nodes ruptured intraoperatively, discharging frank pus. A swab of this pus and tissue samples of the excised nodes were sent for routine and mycobacterial culture, Mycobacterium tuberculosis PCR testing, and histology. Mycobacterial culture included inoculation of a BacT/Alert MP broth (BioMérieux, Marcy L'Etoile, France), as well as Lowenstein-Jensen slopes (Fort Richard Laboratories, Auckland, New Zealand) incubated at 30 and 35°C and a chocolate agar slope (Fort Richard Laboratories) incubated at 30°C.Histological examination of the resected lymph nodes showed necrotizing granulomatous inflammation with cystic abscess formation. No organisms were seen on Gram, periodic acid-Schiff, or Ziehl-Neelsen staining. No evidence of malignancy was seen. Routine bacteriological cultures of the pus swab taken from the ruptured node and the direct culture of the tissue sample were sterile; however, an enrichment b...

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“…heckeshornense is a recently described atypical mycobacterium closely related to M. xenopi and differentiated on the basis of 16S rRNA sequencing 7 . Only a handful of cases of infection have been reported with this organism, most often in immunocompetent patients [4][5][6][7] ; most have been pulmonary infections, although there is one report of tenosynovitis 5 .…”

Section: To the Editormentioning

confidence: 99%

Mycobacterium heckeshornenseLumbar Spondylodiskitis in a Patient with Rheumatoid Arthritis Receiving Etanercept Treatment

Elyousfi¹,

Leiter²,

Goytan³

et al. 2009

J Rheumatol

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Mycobacterium heckeshornense Infection in an Immunocompetent Patient and Identification by 16S rRNA Sequence Analysis of Culture Material and a Histopathology Tissue Specimen

Cited by 19 publications

References 16 publications

Mycobacterium heckeshornense Lung Infection that was Diagnosed as Mycobacterium xenopi Disease by DNA-DNA Hybridization (DDH)

Mycobacterium heckeshornense Lung Infection that was Diagnosed as Mycobacterium xenopi Disease by DNA-DNA Hybridization (DDH)

First Case of Mycobacterium heckeshornense Lymphadenitis

Mycobacterium heckeshornenseLumbar Spondylodiskitis in a Patient with Rheumatoid Arthritis Receiving Etanercept Treatment

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