<i>Mycobacterium szulgai</i> pulmonary infection in a vitamin D–deficient patient: A case report

Lotfi, Hadi; Sankian, Mojtaba; Meshkat, Zahra; Soltani, Ahmad Khalifeh; Aryan, Ehsan

doi:10.1002/ccr3.3692

Cited by 6 publications

(2 citation statements)

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“…It is a rare pathogen and accounts for less than 0.5% of all nontuberculous mycobacterial (NTM) infections [ 4 ]. M. szulgai infections present with a variety of clinical manifestations, ranging from predominantly pulmonary to rarely cutaneous infection [ 5 – 8 ]. Here we report the first case of cutaneous Mycobacterium szulgai infection in a patient with ACTH-independent Cushing’s syndrome, and summarize the literature on cutaneous M. szulgai infection.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Mycobacterium szulgai infection in a patient with Cushing's syndrome: a case report and literature review

et al. 2023

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Background Opportunistic infection is an under-recognized complication of Cushing’s syndrome, with infection due to atypical mycobacterium rarely reported. Mycobacterium szulgai commonly presents as pulmonary infection, with cutaneous infection seldom reported in the literature. Case Presentation 48-year-old man with a newly-diagnosed Cushing’s syndrome secondary to adrenal adenoma presented with a subcutaneous mass on the dorsum of his right hand, was diagnosed with cutaneous Mycobacterium szulgai infection. The most likely source of the infection was through minor unnoticed trauma and inoculation from a foreign body. The patient’s Cushing’s syndrome, high serum cortisol levels and secondary immune suppression facilitated mycobacterial replication and infection. The patient was successfully treated with adrenalectomy, surgical debridement of cutaneous lesion, and a combination of rifampicin, levofloxacin, clarithromycin, and ethambutol for 6 months. There were no signs of relapse one year after cessation of anti-mycobacterial treatment. A literature review on cutaneous M. szulgai infection to further characterize the clinical characteristics of this condition, identified 17 cases of cutaneous M. szulgai infection in the English literature. Cutaneous M. szulgai infections with subsequent disease dissemination are commonly reported in immunocompromised hosts (10/17, 58.8%), as well as in immunocompetent patients with a history of breached skin integrity, such as invasive medical procedures or trauma. The right upper extremity is the most commonly involved site. Cutaneous M. szulgai infection is well controlled with a combination of anti-mycobacterial therapy and surgical debridement. Disseminated infections required a longer duration of therapy than localized cutaneous infections. Surgical debridement may shorten the duration of antibiotics. Conclusions Cutaneous M. szulgai infection is a rare complication of adrenal Cushing’s syndrome. Further studies are needed to provide evidence-based guidelines on the best combination of anti-mycobacterial and surgical therapy for managing this rare infective complication.

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Section: Introductionmentioning

confidence: 99%

Cutaneous Mycobacterium szulgai infection in a patient with Cushing's syndrome: a case report and literature review

et al. 2023

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“…The most common presentation resembles pulmonary tuberculosis, but it may also present as an extrapulmonary disease. Infection primarily occurs in individuals with underlying lung disease or immunocompromising conditions [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium szulgai Pulmonary Infection in an Immunocompromised Patient

Neves,

Pos,

Horta

et al. 2023

Cureus

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Mycobacterium szulgai is a slow-growing nontuberculous mycobacterium (NTM). It was first described in 1972 and is responsible for less than 0.2% of all NTM infections. The most common presentation resembles pulmonary tuberculosis, but it may also present as an extrapulmonary disease. It primarily affects individuals with underlying lung disease or immunocompromising conditions. The increasing use of tumor necrosis factor-alpha inhibitors, such as adalimumab, is associated with an increased risk of serious infections. We report a case of Mycobacterium szulgai infection in a 23-year-old woman with a history of childhood pneumonia and Crohn’s disease on adalimumab.

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On the Complex Pathogenesis of Sjögren’s Syndrome: Genetics, Epigenetics, Toxins, Viruses, and Bacteria

Finzel

Voll

2022

Contemporary Rheumatology

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Mycobacterium szulgai pulmonary infection in a vitamin D–deficient patient: A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 6 publications

References 10 publications

Cutaneous Mycobacterium szulgai infection in a patient with Cushing's syndrome: a case report and literature review

Cutaneous Mycobacterium szulgai infection in a patient with Cushing's syndrome: a case report and literature review

Mycobacterium szulgai Pulmonary Infection in an Immunocompromised Patient

On the Complex Pathogenesis of Sjögren’s Syndrome: Genetics, Epigenetics, Toxins, Viruses, and Bacteria

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