2023
DOI: 10.1093/femsml/uqad006
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Mycobacterium tuberculosisinfection triggers epigenetic changes that are enriched in a type I IFN signature

Abstract: Tuberculosis, a deadly infectious lung disease caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of bacterial disease-related deaths worldwide. Mtb reprograms and disables key antibacterial response pathways, many of which are regulated by epigenetic mechanisms that control the accessibility of chromatin to the transcriptional machinery. Recent reports suggest that host phosphatases, such as PPM1A, contribute to regulating chromatin accessibility during bacterial infections. However, change… Show more

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Cited by 5 publications
(4 citation statements)
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“…3 C). These pivotal pathways play a pivotal role in orchestrating the immune response to PTB infection, potentially fostering robust immunity against pathogens while concurrently posing the risk of immune exhaustion and tissue damage 28 , 29 . The robust activation of the positive regulation of hemopoiesis pathway in C3 hints at a tightly intertwined interaction between the body's immune system and hematopoietic system during PTB infection (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…3 C). These pivotal pathways play a pivotal role in orchestrating the immune response to PTB infection, potentially fostering robust immunity against pathogens while concurrently posing the risk of immune exhaustion and tissue damage 28 , 29 . The robust activation of the positive regulation of hemopoiesis pathway in C3 hints at a tightly intertwined interaction between the body's immune system and hematopoietic system during PTB infection (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Chen et al reported histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation, which are associated with active pulmonary TB disease in blood leukocytes [46]. Madden et al used transcriptomic profiling by RNA-seq to demonstrate changes in the expression of genes involved in type I interferon signalling pathways during MTB infection [47]. Our data are generally consistent with studies by Madden et al, where MTB, after 18 h of infection, triggered a marked reduction in immune-related genes, unlike what was seen at 6 h. Indeed, the reshaping of chromatin structure and gene repression is the target of many mycobacterial secretory proteins which in turn have moonlighting functions on the host immune genes.…”
Section: Discussionmentioning
confidence: 99%
“…Raw sequencing files were processed as described in Madden et al (27). Alignment was performed on version mm9 of the mouse genome.…”
Section: Atac-seq Data Processing and Analysismentioning
confidence: 99%
“…To align this study's ATAC-seq data with mRNA expression levels from comparable samples, RNA-seq data from Machado et al was downloaded from the NCBI Gene Expression Omnibus accession GSE103164 using the provided count matrix and processed using a standard pipeline (27). Unwanted variation was reduced using the RUVr algorithm and a k value of 2.…”
Section: Atac-seq Data Processing and Analysismentioning
confidence: 99%