<i>Mycoplasma pneumoniae</i>‐associated mucositis with cutaneous involvement – a case report

Grieb, Alexander; Kaderschabek, Nicole; Orasche, Christian; Minkov, Milen; Sanlorenzo, Martina; Rappersberger, Klemens; Vujic, Igor

doi:10.1111/ddg.13714

Cited by 4 publications

(10 citation statements)

References 6 publications

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“…In the literature, we find terms such as "incomplete SJS", "SJS without skin lesions", "atypical SJS" or recently "Fuchs syndrome", "M. pneumoniae-associated mucositis (MPAM)" and "M. pneumoniae-induced rash and mucositis (MIRM) sine rash" to describe patients who, in the context of an MP infection, develop extensive mucositis consistent with SJS, but with minimal or no cutaneous involvement [1,2,[4][5][6][7][8][9][10][11]. Whether MPAM should be considered a separate entity from SJS or it belongs in the same spectrum is still debated [1,2,4,5].…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiologic mechanism of MPAM is not completely known [1,2,4,5,11]. It could be explained by molecular mimicry between MP P1-adhesion molecules and a specific antigen that induces the production of cross-reacting autoantibodies by B lymphocytes [1,2,4,11].…”

Section: Discussionmentioning

confidence: 99%

“…MPAM usually develops in young males (< 18 years), presenting prodromes during the previous week with coughing, fever and general discomfort [1,2,[4][5][6][7][8][9][10][11]. Mucosal involvement is intense and fundamental for the diagnosis, with oral involvement most frequent (94-100 %, with erosions or denudation of the entire mucosa), followed by conjunctival involvement (82-97 %, with bilateral conjunctivitis) and urogenital involvement (63-78 %, with ulcerations and vesiculobullous lesions) [1,4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Two or more mucosal sites are usually involved [1,2]. Cutaneous lesions, if present (31-60 %), consist of vesicular blisters and/or a scant number of target lesions in acral locations [1,2,4,11].…”

Section: Discussionmentioning

confidence: 99%

“…Biopsy of the oral mucosa usually reveals necrosis and a superficial lymphocytic infiltrate most consistent with SJS/TEN [5,9]. Positive results for serology and/or PCR tests for MP in samples from the oropharynx may be useful to demonstrate MP infection [1,2,4,5,11]. In recent years, MP IgA serum levels have been suggested as a useful diagnostic marker of an acute MP infection because they are not influenced by the patient's age, unlike IgM and IgG levels [5].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Fever, cough and mucosal lesions in a young man

Lobo

Lara

Fernández

2020

J Deutsche Derma Gesell

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Fever, cough and mucosal lesions in a young man

Lobo

Lara

Fernández

2020

J Deutsche Derma Gesell

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Bilateral Limbus-Sparing Conjunctivitis in a Boy With Rash and Pneumonia

2019

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An adolescent boy presented to the hospital with bilateral eye redness, an erythematous chest rash, lip blistering, and worsening sore throat for 2 days while undergoing a 10-day outpatient treatment course of ciprofloxacin and trimethoprim-sulfamethoxazole for community-acquired pneumonia. He complained of a cough, sore throat, and ocular itching. He denied prior ocular history and reported no visual changes. He had no significant medical history aside from documented allergies to β-lactam, macrolide, and cephalosporin antibiotics resulting in rashes, angioedema, and hives.The patient was febrile on admission, and results from chest radiography were consistent with pneumonia. Bedside ophthalmic examination revealed bilateral limbus-sparing conjunctival hyperemia that blanched minimally with phenylephrine, bilateral nasal and temporal conjunctival epithelial ulcerations, and inferior forniceal pseudomembranes (Figure , A). There were no symblephara or eyelid margin defects. Examination of the face revealed erosions with hemorrhagic crusts on the lip mucosa (Figure , B) but no associated cutaneous lesions or desquamation. Findings from the remainder of the ophthalmologic examination, including visual acuity, intraocular pressure, and dilated fundus examination, were unremarkable. Mycoplasma pneumoniae IgG and IgM titers were obtained and found to be within normal limits.

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Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: a review

Gao,

Sun

2024

Annals of Medicine

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Mycoplasma pneumoniae (MP) is the cause of Mycoplasma pneumoniae pneumonia (MPP) in children and adolescents, with the clinical manifestations highlighted by intermittent irritating cough, accompanied by headache, fever and muscle pain. This paper aimed to study the research status and focal points in MP infection, especially the common laboratory diagnostic methods and clinical treatment of Mycoplasma pneumoniae . Laboratory diagnostic methods include molecular assay, serological antibody detection, rapid antigen detection and isolation and culture. Polymerase chain reaction (PCR) is the gold standard with high sensitivity and specificity. The serological antibody can detect various immune antibodies qualitatively or quantitatively in serum. Rapid antigen can be detected faster, with no equipment environment requirements, which can be used for the early diagnosis of MP infection. While the culture growth cycle is long and insensitive, not recommended for routine diagnosis. Macrolides were the preferred drug for children with MPP, while the drug resistance rate was rising in China. Tetracycline can be substituted but was not recommended for children under 8 years of age, quinolone drugs are not necessary, severe MPP can be combined with glucocorticoids, involving the nervous or immune system can choose gamma globulin. Other treatments for MPP including symptomatic treatment which can alleviate symptoms, improve lung function and improve prognosis. A safe and effective vaccine needed to be developed which can provide protective immunity to children and will reduce the incidence of MPP.

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Mycoplasma pneumoniae‐associated mucositis with cutaneous involvement – a case report

Cited by 4 publications

References 6 publications

Fever, cough and mucosal lesions in a young man

Fever, cough and mucosal lesions in a young man

Bilateral Limbus-Sparing Conjunctivitis in a Boy With Rash and Pneumonia

Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: a review

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