<i>N</i>‐Acetyl‐β‐<scp>d</scp>‐Glucosaminidase Index as an Early Biomarker for Chronic Kidney Disease in Cats with Hyperthyroidism

Lapointe, Catherine; Bélanger, Marcel; Dunn, Marilyn; Moreau, M.; Bédard, Christian

doi:10.1111/j.1939-1676.2008.0168.x

Cited by 34 publications

(35 citation statements)

References 38 publications

(66 reference statements)

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“…18,19 It also has been evaluated as a biomarker for the development of azotemia in hyperthyroid cats treated with methimazole. 20 In that study, NAG indexed to urinary creatinine was unable to differentiate cats at risk of developing azotemia. Recent data from our group indicated that the correlation between NAG index and plasma creatinine concentration is poor, but that NAG index may correlate with the magnitude of proteinuria.…”

Section: Abbreviationsmentioning

confidence: 87%

Evaluation of Predictors of the Development of Azotemia in Cats

Jepson¹,

Brodbelt

Vallance³

et al. 2009

Veterinary Internal Medicne

128

136

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Background: Chronic kidney disease (CKD) is a common condition in geriatric cats. Diagnosis is based on the development of persistent azotemia with inadequate urine concentrating ability. Biomarkers are sought for early identification.Hypothesis: Clinical variables, urine concentrating ability, proteinuria, and N‐acetyl‐β‐d‐glucosaminidase (NAG) index will be predictive of cats at risk of developing azotemia within 12 months.Animals: Client‐owned nonazotemic geriatric (≥9 years) cats.Methods: Prospective longitudinal cohort study monitoring a population of healthy nonazotemic geriatric cats every 6 months until development of azotemia, death, or the study end point (September 30, 2007). Multivariable logistic regression analysis was used to assess baseline clinical, biochemical, and urinalysis variables, urine protein to creatinine ratio (UP/C), urine albumin to creatinine (UA/C) ratio, and urinary NAG index as predictors of development of azotemia.Results: One hundred and eighteen cats were recruited with a median age of 13 years. Ninety‐five cats (80.5%) had been followed or reached the study end point by 12 months of which 30.5% (29/95) developed azotemia. Age, systolic blood pressure, plasma creatinine concentration, urine specific gravity, UP/C, UA/C, and NAG index were significantly associated with development of azotemia in the univariable analysis (P≤ .05). However, in the multivariable analysis, only plasma creatinine concentration with either UP/C (Model 1) or UA/C (Model 2) remained significant.Conclusions and Clinical Importance: This study demonstrates a high incidence of azotemia in a population of previously healthy geriatric cats. Proteinuria at presentation was significantly associated with development of azotemia although causal association cannot be inferred. Evaluation of NAG index offered no additional benefit.

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Section: Abbreviationsmentioning

confidence: 87%

Evaluation of Predictors of the Development of Azotemia in Cats

Jepson¹,

Brodbelt

Vallance³

et al. 2009

Veterinary Internal Medicne

128

136

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“…Although proteinuria usually resolves after treatment of hyperthyroidism, its presence prior to treatment is correlated with reduced survival but not development of azotemia (Williams et al, 2010b). Although these markers are present in the urine of hyperthyroid cats, they have not proved useful in predicting which cats are likely to become azotemic after treatment (Lapointe et al, 2008;van Hoek et al, 2009b). In one study urine culture was positive in 11 of 90 (12%) of hyperthyroid cats, and 17 of 77 (22%) cats with CKD.…”

Section: Urinalysismentioning

confidence: 99%

Feline Hyperthyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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“…Ademais, gatos com insuficiência renal crônica demonstraram elevação dessa enzima antes da elevação das concentrações séricas de ureia e creatinina (SATO et al, 2002). Essa enzima também pode ser uma ferramenta interessante na monitoração da lesão renal progressiva durante a terapia de gatos com hipertireoidismo (LAPOINTE et al, 2008). Não existem kits laboratoriais no Brasil disponíveis para a realização deste exame.…”

Section: Enzimas Urináriasunclassified

Testes de avaliação de injúria renal precoce em cães e gatos

2014

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ResumoA identificação de injúrias renais é uma medida importante que tem como objetivo evitar a instalação de alterações irreversíveis, tal como a doença renal crônica, problema de incidência elevada em cães e gatos. As concentrações séricas de ureia e de creatinina são os parâmetros rotineiramente avaliados, quando se busca a identificação de insuficiência renal. Porém, estes valores só se encontram alterados quando 66 a 75% dos néfrons apresentam incapacidade de função excretora. Em muitas situações, uma agressão desta magnitude pode ser suficiente para causar a morte do animal. Avaliações que identifiquem a agressão, antes mesmo que as funções encontrem-se alteradas vêm sendo estudadas, mostrando serem importantes avaliadores precoces de possíveis danos irreversíveis. A quantificação das enzimas urinárias, proteína urinária, fração de excreção de eletrólitos, taxa de filtração glomerular e a observação do sedimento urinário têm grande valor como exames sensíveis de injúria renal precoce. Há a necessidade do emprego de testes que auxiliem, não somente na identificação precoce, mas também na determinação da progressão da doença e da eficácia do tratamento. A presente revisão objetiva descrever os testes laboratoriais que podem ser realizados para a avaliação precoce de injúria renal de cães e gatos. Palavras-chave: Injúria renal, diagnóstico precoce, taxa de filtração glomerular, proteinúria AbstractThe identification of kidney injury is an important measure that aims to prevent the installation of irreversible changes, such as chronic kidney disease, seen most frequently in dogs and cats. Serum urea and creatinine parameters are routinely assessed, when searching renal failure. However, these values are only changed when 66 to 75% of glomerular filtration rate has been lost. In many situations, an attack of this magnitude may be enough to cause the animal's death. Evaluations that identify the aggression, even before the functions themselves are altered, have been studied and shown to be important early evaluators, signaling prior to possible irreversible damage. The quantification of urinary enzymes, urinary protein, fractional excretion of electrolytes, glomerular filtration rate and urinary sediment, have shown great value as sensitive tests of renal injury. There is the need of the use of tests that assists in early diagnosis and also determines the progression of disease and efficacy of the treatment. The present review aims to describe the laboratory tests that may be performed to evaluate early kidney injury in dogs and cats.

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N‐Acetyl‐β‐d‐Glucosaminidase Index as an Early Biomarker for Chronic Kidney Disease in Cats with Hyperthyroidism

Cited by 34 publications

References 38 publications

Evaluation of Predictors of the Development of Azotemia in Cats

Evaluation of Predictors of the Development of Azotemia in Cats

Feline Hyperthyroidism

Testes de avaliação de injúria renal precoce em cães e gatos

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