<i>N</i>-Acetylcysteine alleviates high fat diet-induced hepatic steatosis and liver injury<i>via</i>regulating the intestinal microecology in mice

Ding, Qiong; Guo, Rui; Pei, Liuhua; Lai, Shanglei; Li, Jiaomei; Yin, Yuehui; Xu, Tiantian; Yang, Wenwen; Song, Qing; Han, Qiang; Dou, Xiaobing; Li, Songtao

doi:10.1039/d1fo03952k

Cited by 23 publications

(21 citation statements)

References 56 publications

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“…The increased activities of plasma aspartate transaminase (AST) and alanine aminotransferase (ALT) are gold indicators of liver injury. 22 In this study, we found that chronic alcohol feeding increased the activities of plasma ALT and AST, and the above indicators were the most increased in the AF/OO group (Fig. 2a and b).…”

Section: Resultssupporting

confidence: 52%

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice

et al. 2023

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Section: Resultssupporting

confidence: 52%

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice

et al. 2023

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“…NAFLD, if not treated properly, can progress into a fatal disease, such as nonalcoholic steatohepatitis, fibrosis, cirrhosis, or liver cancer, which are the final stages of liver disease . According to one study, giving mice a high-fat diet (HFD) can cause NAFLD and liver damage, however, various studies indicate that natural products extracted from certain plants or fruits have protective effects against NAFLD. , In this study, the HFD-induced mouse model was studied to investigate the involvement and mechanism of astaxanthin (AT) in NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Intestinal Flora and Targeting the AMPK/Nrf2 Signal Axis

Liu

et al. 2022

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD) is among the most prevalent chronic liver diseases around the globe. The accumulation of lipids in the liver and oxidative stress are important pathological mechanisms of NAFLD. Astaxanthin (AT) is a carotenoid extracted from shrimps and crabs with beneficial biological activities, including anti-oxidative and anti-inflammatory activities. 16S microflora sequencing, H&E staining, and the western blot technique were employed to investigate the impacts of AT on a high-fat diet (HFD)-induced NAFLD. Significant mitigation in lipid metabolism-related disorders and decreased oxidative stress in HFD-induced mice were observed due to AT, and significant changes in the gut flora of the model mice were also observed. The in vitro study showed that AT considerably lowered the protein expression level of fatty acid synthetase (FAS), sterol regulatory element-binding protein-1c (SREBP-1c), and acetyl-COA carboxylase (ACC) and increased the protein expression of nuclear factor-E2 associated factor 2 (Nrf2) and AMP-activated protein kinase (AMPK) in oleic acid (OA) and palmitic acid (PA)-induced HepG2 cells. Additionally, mechanistic studies revealed that compound C (AMPK inhibitor, CC) inhibited the regulatory effect of AT on the SREBP-1c and Nrf2 signaling pathways. In conclusion, AT can inhibit the SREBP-1c, FAS, and ACC signaling pathways, activate the AMPK and Nrf2 signaling pathways, and improve the structure of intestinal flora.

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“…Moreover, comprehensive examination of the NAFLD etiology induced by overnutrition and obesity showed that an alteration of the gut microbiota has emerged as a crucial element in promoting the occurrence of NAFLD ( 6 ). The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and triglycerides (TG) were significantly elevated by a high-fat diet (HFD) in C57BL/6 mice with NAFLD ( 26 ). Consequently, HFD decreased the special operational taxonomic units (OTUs) and Shannon diversity index of the microbiota, which suggested that HFD caused an imbalance in the homeostasis of the gut microbial community.…”

Section: Link Of Microbiota To the Non-alcoholic Fatty Liver Disease ...mentioning

confidence: 99%

“…In addition, Erysipelotrichaceae positively regulated the expression of Cidea, CD36, Acnat2, Mogat1, and GPAT3. Previous studies have suggested that Cidea, CD36, and GPAT3 are involved in the lipid metabolism pathway that drives the occurrence of HS ( 26 ). Third, F. prausnitzii can also regulate genes related to other pathways, such as IRS-1/2, IL-6, SOCS3, LEPR, and steroid response element binding protein-α (SREBP-α), to prevent the development of NAFLD ( 40 ).…”

Section: Link Of Microbiota To the Non-alcoholic Fatty Liver Disease ...mentioning

confidence: 99%

Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

et al. 2022

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The increasing prevalence of non-alcoholic fatty liver disease (NAFLD), which is a progressive disease, has exerted huge a healthcare burden worldwide. New investigations have suggested that the gut microbiota closely participates in the progression of NAFLD through the gut–liver axis or gut–brain–liver axis. The composition of the microbiota can be altered by multiple factors, primarily dietary style, nutritional supplements, or exercise. Recent evidence has revealed that gut microbiota is involved in mitochondrial biogenesis and energy metabolism in the liver by regulating crucial transcription factors, enzymes, or genes. Moreover, microbiota metabolites can also affect mitochondrial oxidative stress function and swallow formation, subsequently controlling the inflammatory response and regulating the levels of inflammatory cytokines, which are the predominant regulators of NAFLD. This review focuses on the changes in the composition of the gut microbiota and metabolites as well as the cross-talk between gut microbiota and mitochondrial function. We thus aim to comprehensively explore the potential mechanisms of gut microbiota in NAFLD and potential therapeutic strategies targeting NAFLD management.

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N-Acetylcysteine alleviates high fat diet-induced hepatic steatosis and liver injuryviaregulating the intestinal microecology in mice

Abstract: N-acetylcysteine (NAC), a well-accepted antioxidant, has been shown to protect against high fat diet (HFD)-induced obesity-associated non-alcoholic fatty liver disease (NAFLD) in mice. However, the underlying mechanism(s) of the beneficial...

Cited by 23 publications

References 56 publications

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice

Astaxanthin Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Intestinal Flora and Targeting the AMPK/Nrf2 Signal Axis

Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

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