<i>Onosma mutabilis</i>: Phytochemical composition, antioxidant, cytotoxicity, and acute oral toxicity

Jabbar, Ahmed Aj

doi:10.1002/fsn3.2544

Cited by 22 publications

(26 citation statements)

References 80 publications

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“…exert these activities, i. e., Onosma limitaneum – antitumor, O. argentatum – antimicrobial activity, and that these activities may be ascribed in part to the presence of phenolic compounds, which may be also the case with samples collected in Serbia. Moreover, Jabbar [40] showed that O. mutabilis methanolic extract has promising antioxidant and cytotoxic activities as well. Aqueous extracts of O. bracteatum inhibited growth of S. aureus (25.3 mm inhibition zone), but not of E. coli , B. subtilis and P. mirabilis ; this was not the case for E. coli strains in the present study [41] …”

Section: Resultsmentioning

confidence: 99%

Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents

Kostić

Mačukanović-Jocić

Milinčić

et al. 2022

Chemistry & Biodiversity

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The current study aimed to phytochemically characterize (including a detailed phenolic profile) two endemic Balkan's species (Hieracium waldsteinii and Onosma stellulata) and determine their possible application as a source of natural antioxidant and antimicrobial agents. The main phenolic compound in both species (in all examined parts) was chlorogenic acid. Eriodictyol, genistein and naringenin were quantified only in H. waldsteinii while isorhamnetin‐3‐O‐rutinoside and sinapic acid were characteristic for O. stellulata. The highest antioxidant activity (98 mg AAE/g dry weight for TAC assay) was ascribed to the flower extract of H. waldsteinii while the lowest results (∼4.3 mg AAE/g dry weight for FRP assay) were exhibited by the extracts obtained from the plant's stem. Antimicrobial assays showed moderate antibacterial, i. e., moderate/strong activity against several tested fungi (in particular Trichoderma viride). Correlation analysis revealed strong positive connection between phenolic compounds and reducing power of extracts as well as between total phenolic and flavonoid content and the obtained minimal inhibitory concentration recorded in antibacterial assays.

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Section: Resultsmentioning

confidence: 99%

Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents

Kostić

Mačukanović-Jocić

Milinčić

et al. 2022

Chemistry & Biodiversity

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“…O. L. species are primarily found in Asia, the Mediterranean region, Eurasia, and Europe, particularly in China, Iran, Syria, India, Turkey, Pakistan, and Sri Lanka [31][32][33][34]. Kumar et al [35] highlighted how distribution patterns of different O. L. species vary geographically.…”

Section: Geographical Distribution Of O Lmentioning

confidence: 99%

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight

Kumar

Attri

Kaur

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

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Onosma (O.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally used to treat rheumatism, fever, asthma, stomach irritation, and inflammatory ailments. The bioactive constituents present in the genus O. include benzoquinones, naphthazarins, alkaloids, phenolic, naphthoquinones, and flavonoids whereas shikonins and onosmins are the most significant. The review compiled contemporary research on O. L., including its distribution, morphology, traditional applications, phytochemistry, ethnopharmacology, and toxicology. This review also highlights a few critical challenges and possible future directions for O. L. research. Modern research has demonstrated a wide range of pharmacological effects of different species of O. L., including anti-diabetic, anticancer, anti-inflammatory, and cardiovascular protective. However, the studies on the O. genus are still not fully explored, therefore, researchers need to discover novel products with their toxicity studies, molecular mechanism, and associated side effects. Future exploration of potent constituents from this genus and clinical trials are required to explore its pharmacological importance.

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“…For instance, metformin is a synthetic drug that can effectively adjust glucose metabolism; however, researchers have shown its side effects on the functionality of islet cells 16 . As an alternative for synthetic anti-diabetics, searching for α-amylase and α-glucosidase inhibitors in natural sources like plants, become a continuous mission by scientists 2,17 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profile, Antioxidant, Enzyme inhibitory and acute toxicity activity of Astragalus bruguieri

Jabbar,

Abdulrahman,

Abdulsamad

et al. 2023

Baghdad Sci.J

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The medicinal plants (Astragalus species) have been used traditionally as anti-inflammatory, antioxidant, and Anti-diabetics. The current research investigates the phytochemistry and some biological activity of methanol extract of different parts of Astragalus bruguieri Bioss., a wild medicinal plant grows on Safeen mountain, Erbil, Iraq. The methanol extracts of A. bruguieri were analyzed for total phenolic, flavonoid, and saponin contents. In-vitro antioxidant activity was analyzed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Furthermore, the plant extracts were examined for in-vitro enzyme inhibitory activity and in-vivo sub-acute toxicity. The results have shown the highest total phenolic (28.83, 20.62 mg GAEs/g extracts) contents, in the leave and root extracts, respectively. While the highest total Flavonoid (50.08, 44.01 mg REs/g) contents, were found in the extracts of aerial parts and leaves, respectively. The total saponin was higher (25.33, 23.18 mg GAEs/g extracts) in the roots and aerial parts, respectively. In-vitro antioxidant measurement by (DPPH) assay showed leaves as superior part in this activity (42.19mg TEs/g extract), while antioxidant evaluation by (ABTS) assay indicated roots as the most active part (86.90mg TEs/g extract). The α-glucosidase and αamylase inhibitory activity were found as 0.45-0.67, and 1.2-1.8 mmol ACAEs/g, respectively. The oral acute toxicity test indicated the safety of 600mg/kg dosage of different parts of A. bruguieri on albino rats without behavioral abnormality or mortality. The current study is considered as the first report on the A. bruguieri as a possible new source of biocompatible material for many industrial products.

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Onosma mutabilis: Phytochemical composition, antioxidant, cytotoxicity, and acute oral toxicity

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 22 publications

References 80 publications

Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents

Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight

Phytochemical profile, Antioxidant, Enzyme inhibitory and acute toxicity activity of Astragalus bruguieri

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