Osterixfunctions downstream of anti-Müllerian hormone signaling to regulate Müllerian duct regression

Mullen, Rachel D.; Wang, Ying; Liu, Bin; Moore, Emma L.; Behringer, Richard R.

doi:10.1101/237529

Cited by 5 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AMH is activated by proteolytic cleavage of proprotein, and binds specific AMH type 2 receptor [4], followed by the recruitment of SMAD signal transducer proteins [5], leading to their nuclear translocation where they regulate target gene expression [1,4,5]. Along with its role as determinant of the male sexual differentiation, changes in AMH levels, together with follicle-stimulating hormone (FSH) and luteinizing hormone (LH), reflect aging in females [6]. This age-dependent decline in fertility typically begins at the third decade of female's life and deteriorates markedly after age 35 years old.…”

Section: Introductionmentioning

confidence: 99%

Age-dependent changes in anti-Müllerian hormone levels in Lebanese females: correlation with basal FSH and LH levels and LH/FSH ratio: a cross-sectional study

Racoubian¹,

Aimagambetova

Finan

et al. 2020

BMC Women's Health

View full text Add to dashboard Cite

Background: To investigate the age-dependent changes in circulating anti-Müllerian hormone (AMH) levels in healthy Arabic-speaking Lebanese women, and to correlate changes in serum AMH levels with serum FSH and LH values, and LH/FSH ratio. Methods: Cross-sectional study, involving 1190 healthy females, age 17-54 years, with regular menses and both ovaries. Serum AMH levels (ng/ml) were measured by ELISA. Results: There was an inverse proportion of AMH and subject's age, which declined from median 6.71 (2.91) ng/ml in young subjects, to 0.68 (0.45) ng/ml in subjects older than 50 years. Average yearly decrease in median AMH levels was 0.27 ng/ml/year through age 35, but then diminished to 0.12 ng/ml/year afterwards. Receiver operating characteristic curve analysis demonstrated high sensitivity and specificity of age as determinant of AMH levels. In contrast to AMH, FSH levels increased progressively from 5.89 (0.11-62.10) ng/ml in young subjects, to 38.43 (3.99-88.30) ng/ml in subjects older than 50 years. On the other hand, age-dependent changes in LH/FSH ratio paralleled those of AMH. Linear regression modeling testing the independent effect of AMH on FSH and LH, adjusted for age, showed that AMH was significant predictor of FSH and LH/FSH ratio, but not LH. This did not contribute significantly to baseline LH and FSH prediction. Conclusions: Circulating AMH levels are inversely related to age as also shown elsewhere, and are predictors of LH/FSH ratio and FSH but not LH levels in eumenorrheic females.

show abstract

Section: Introductionmentioning

confidence: 99%

Age-dependent changes in anti-Müllerian hormone levels in Lebanese females: correlation with basal FSH and LH levels and LH/FSH ratio: a cross-sectional study

Racoubian¹,

Aimagambetova

Finan

et al. 2020

BMC Women's Health

View full text Add to dashboard Cite

show abstract

“…This may be explained by the multifactorial variability of the endometrial thickness (22). FSH and LH were biochemical markers reflecting aging in women, and they deteriorated significantly after the age of 35 due to the decrease in ovarian reserve (23). The Buyalos and Danesmand studies showed that the E2 level in infertile patients entered the abnormal range within two years of observation (22).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ovarian reserve at late reproductive age

Kulaksiz¹,

Erin²

2022

J. Exp. Clin. Med.

View full text Add to dashboard Cite

Although follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), antimullerian hormone (AMH), and ovarian volume are commonly used to assess ovarian reserve and ovarian response to stimulation, no test directly indicates this. We aimed to observe how ovarian reserve tests help us in the diagnosis and treatment of women of late reproductive age. We included 190 patients in this prospective cohort study. We took FSH, LH, E2 and AMH blood samples on the third day of menstruation to biochemically evaluate the ovarian reserve of the patients who were planned for hysterectomy and bilateral salpingo-oopherectomy at late reproductive age. We recorded antral follicle counts (AFC) and ovarian volumes by transvaginal ultrasonography for ultrasonographic evaluation and weighed ovarian weights postoperatively. The data of 190 women aged 39-44.9 years revealed that AMH and ovarian volume, ovarian volume and AFS show significant positive correlations, whereas FSH, LH, and E2 levels do not indicate a significant relationship with AFS. AMH, ovarian volume and ovarian weight, and AFC may show us the ovarian reserve with the highest reliability in women of late reproductive age.

show abstract

“…AMHR2 recruits 1 of 2 non-specific type I receptors, either BMPR1A or ACVR1, thus inducing the phosphorylation of intracellular proteins SMAD1, SMAD5, and SMAD8 (also called SMAD9) and their translocation to the nucleus, where they regulate target gene expression [Josso, 2019;Moses and Behringer, 2019]. Osterix (OSX) is induced by AMH and involved in müllerian duct regression [Mullen et al, 2018]. β-catenin is required for AMH action [Kobayashi et al, 2011].…”

Section: Amh Action On Müllerian Ductsmentioning

confidence: 99%

AMH and AMHR2 Involvement in Congenital Disorders of Sex Development

Brunello¹,

Rey²

2021

Sex Dev

View full text Add to dashboard Cite

Anti-müllerian hormone (AMH) is 1 of the 2 testicular hormones involved in male development of the genitalia during fetal life. When the testes differentiate, AMH is secreted by Sertoli cells and binds to its specific receptor type II (AMHR2) on the müllerian ducts, inducing their regression. In the female fetus, the lack of AMH allows the müllerian ducts to form the fallopian tubes, the uterus, and the upper part of the vagina. The human AMH gene maps to 19p13.3 and consists of 5 exons and 4 introns spanning 2,764 bp. The AMHR2 gene maps to 12q13.13, consists of 11 exons, and is 7,817 bp long. Defects in the AMH pathway are the underlying etiology of a subgroup of disorders of sex development (DSD) in 46,XY patients. The condition is known as the persistent müllerian duct syndrome (PMDS), characterized by the existence of a uterus and fallopian tubes in a boy with normally virilized external genitalia. Approximately 200 cases of patients with PMDS have been reported to date with clinical, biochemical, and molecular genetic characterization. An updated review is provided in this paper. With highly sensitive techniques, AMH and AMHR2 expression has also been detected in other tissues, and massive sequencing technologies have unveiled variants in AMH and AMHR2 genes in hitherto unsuspected conditions.

show abstract

Osterixfunctions downstream of anti-Müllerian hormone signaling to regulate Müllerian duct regression

Cited by 5 publications

References 41 publications

Age-dependent changes in anti-Müllerian hormone levels in Lebanese females: correlation with basal FSH and LH levels and LH/FSH ratio: a cross-sectional study

Age-dependent changes in anti-Müllerian hormone levels in Lebanese females: correlation with basal FSH and LH levels and LH/FSH ratio: a cross-sectional study

Evaluation of ovarian reserve at late reproductive age

AMH and AMHR2 Involvement in Congenital Disorders of Sex Development

Contact Info

Product

Resources

About