<i>Parmotrema tinctorum</i>exhibits antioxidant, antiglycation and inhibitory activities against aldose reductase and carbohydrate digestive enzymes: an<i>in vitro</i>study

Raj, P. Salin; Prathapan, A.; Sebastian, Jomon; Antony, Antu K.; Riya, Mariam Philip; Rani, Madhu; Biju, H.; Priya, Shanmuga; Raghu, K.

doi:10.1080/14786419.2014.909420

Cited by 20 publications

(6 citation statements)

References 22 publications

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“…Development of natural compounds as AR inhibitors is an urgent need for treatment of diabetic complications. 59 Foods such as cinnamon 60 and lichens 61 have been reported to contain natural compounds as AR inhibitors. Our previous studies using natural product BGG isolated from Indian gooseberry showed robust inhibitory activity against AR with very low cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Chang

Sanborn

et al. 2016

J. Nat. Prod.

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Aldose reductase (AR) in the lens plays an important role in the pathogenesis of diabetic cataract (DC) by contributing to osmotic and oxidative stress associated with accelerated glucose metabolism through the polyol pathway. Therefore, inhibition of AR in the lens may hold the key to prevent DC formation. Emodin, a bioactive compound isolated from plants, has been implicated as a therapy for diabetes. However, its inhibitory activity against AR remains unclear. Our results showed that emodin has good selectively inhibitory activity against AR (IC50 = 2.69 ± 0.90 μM) but not other aldo-keto reductases and is stable at 37 °C for at least 7 days. Enzyme kinetic studies demonstrated an uncompetitive inhibition against AR with a corresponding inhibition constant of 2.113 ± 0.095 μM. In in vivo studies, oral administration of emodin reduced the incidence and severity of morphological markers of cataract in lenses of AR transgenic mice. Computational modeling of the AR–NADP–emodin ternary complex indicated that the 3-hydroxy group of emodin plays an essential role by interacting with Ser302 through hydrogen bonding in the specificity pocket of AR. All the findings above provide encouraging evidence for emodin as a potential therapeutic agent to prevent cataract in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Chang

Sanborn

et al. 2016

J. Nat. Prod.

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“…Their antidiabetic potential has received considerable attention in the recent past. The Parmotrema species, including P. tinctorum [55] has shown promising potential in both antidiabetic and antioxidant [56]. Therefore, investigation of lichens as an alternative antidiabetic food source presents an exciting opportunity.…”

Section: Biological Activitymentioning

confidence: 99%

UPLC–MS/MS quantitative analysis and structural fragmentation study of five Parmotrema lichens from the Eastern Ghats

Kumar

Siva

Sarma

et al. 2018

Journal of Pharmaceutical and Biomedical Analysis

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Comparative phytochemical analysis of five lichen species [Parmotrema tinctorum (Delise ex Nyl.) Hale, P. andinum (Mull. Arg.) Hale, P. praesorediosum (Nyl.) Hale, P. grayanum (Hue) Hale, P. austrosinense (Zahlbr.) Hale] of Parmotrema genus were performed using two complementary UPLC-MS systems. The first system consists of high resolution UPLC-QToF-MS/MS spectrometer and the second system consisted of UPLC-MS/MS in Multiple Reaction Monitoring (MRM) mode for quantitative analysis of major constituents in the selected lichen species. The individual compounds (47 compounds) were identified using Q-ToF-MS/MS, via comparison of the exact molecular masses from their MS/MS spectra, the comparison of literature data and retention times to those of standard compounds which were isolated from crude extract of abundant lichen, P. tinctorum. The analysis also allowed us to identify unknown peaks/compounds, which were further characterized by their mass fragmentation studies. The quantitative MRM analysis was useful to have a better discrimination of species according to their chemical profile. Moreover, the determination of antioxidant activities (ABTS inhibition) and Advance Glycation Endproducts (AGEs) inhibition carried out for the crude extracts revealed a potential antiglycaemic activity to be confirmed for P. austrosinense.

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“…These include Everniastrum cirrhatum , Usnea sinensis , Ramalina conduplicans , R. hossei , Parmotrema tinctorum, P. pseudotinctorum, [29], Flavoparmelia caperata , Physcia aipolia , Heterodermia leucomela [30], Ramalina sinensis , Heterodermia leucomela , Herpothallon sp., Parmotrema reticulatum [31], Parmotrema tinctorum [32], Usnea articulate , Ramalina pollinaria , Ramalina hyrcana , Cladonia rei , Flavoparmelia caperata , Parmotrema chinense , Punctelia subrudecta , Punctelia borreri , Hyperphyscia adglutinata , and Peltigera praetextata [33]. …”

Section: In Vitro Antidiabetic Activities Of Lichen Extractsunclassified

Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review

Thadhani

Karunaratne

2017

Oxidative Medicine and Cellular Longevity

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The advancement in the knowledge of potent antioxidants has uncovered the way for greater insight in the treatment of diabetic complications. Lichens are a rich resource of novel bioactive compounds and their antioxidant potential is well documented. Herein we review the antidiabetic potential of lichens which have received considerable attention, in the recent past. We have correlated the antidiabetic and the antioxidant potential of lichen compounds. The study shows a good accordance between antioxidant and antidiabetic activity of lichens and points out the need to look into gathering the scarce and scattered data on biological activities for effective utilization. The review establishes that the lichen extracts, especially of Parmotrema sp. and Ramalina sp. have shown promising potential in both antidiabetic and antioxidant assays. Ubiquitous compounds, namely, zeorin, methylorsellinate, methyl-β-orcinol carboxylate, methyl haematommate, lecanoric acid, salazinic acid, sekikaic acid, usnic acid, gyrophoric acid, and lobaric acid have shown promising potential in both antidiabetic as well as antioxidant assays highlighting their potential for effective treatment of diabetic mellitus and its associated complications. The available compilation of this data provides the future perspectives and highlight the need for further studies of this potent herbal source to harvest more beneficial therapeutic antidiabetic drugs.

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Parmotrema tinctorumexhibits antioxidant, antiglycation and inhibitory activities against aldose reductase and carbohydrate digestive enzymes: anin vitrostudy

Cited by 20 publications

References 22 publications

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

UPLC–MS/MS quantitative analysis and structural fragmentation study of five Parmotrema lichens from the Eastern Ghats

Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review

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