Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review

Thadhani, Vinitha M.; Karunaratne, Veranja

doi:10.1155/2017/2079697

Cited by 42 publications

(20 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zeorin (1) and atranorin (2) have shown antidiabetic and antioxidant activities. 15 Triterpene 1 also showed strong activity against bacteria and fungi. 16 Depside 2 exhibited anti-proliferative action against malignant cell lines, 17 antinociceptive effects [18][19] and antibiotic action against M. aurum.…”

Section: Resultsmentioning

confidence: 98%

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.

Ragasa¹,

Tan²,

Linis³

et al. 2018

View full text Add to dashboard Cite

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst. ABSTRACT Introduction: Parmotrema austrocetratum Elix and J. Johnst. (syn. Rimelia austrocetrata Elix and J. Johnst.) which belongs to a large genus of lichenized fungi, Parmotrema Massalongo under family Parmeliaceae was investigated for its chemical constituents. Methods: The compounds were isolated by silica gel chromatography and their chemical structures were elucidated by NMR spectroscopy. Results: Chemical investigation of the dichloromethane extract of Parmotrema austrocetratum Elix and J. Johnst. has led to the isolation of zeorin (1) and atranorin (2). Conclusion: P. austrocetratum shares similar chemical characteristic with other Parmotrema species which afforded atranorin. This work highlights the first reported isolation of 1 from P. austrocetratum and the genus Parmotrema. ABSTRACT SUMMARY • Chemical investigation of the dichloromethane extract of P. austrocetratum has led to the isolation of zeorin (1) and atranorin (2). This is the first report on the isolation of 1 from P. austrocetratum and the genus Parmotema.Consolacion Y. Ragasa: Full Professor 10

show abstract

Section: Resultsmentioning

confidence: 98%

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.

Ragasa¹,

Tan²,

Linis³

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Lichens are composite, symbiotic organisms consisting of a fungal partner (mycobiont) and one or more photosynthetic partners (photobiont) that are usually green algae, cyanobacteria, or both. Several studies have reported that lichen metabolites possess potent α-glucosidase inhibitory activity [3][4][5]. In previous studies on the Vietnamese lichen Parmotrema tsavoense, we described several novel depsidones and diphenyl ethers [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense

et al. 2020

View full text Add to dashboard Cite

Chemical investigation of the lichen Parmotrema tsavoense led to the isolation of 5 new depsidones, parmosidones F – J (1 – 5). These compounds were structurally elucidated using spectroscopic methods including HRESIMS and 2D NMR data. Compounds 1, 3, and 4 were evaluated for their inhibition of α-glucosidase. All exhibited potent α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 17.6 µM, which was much lower than that of the positive control acarbose (IC50 449 µM).

show abstract

“…Although there is no reported biological activity for M. orthostichum, the compounds isolated from the plant were reported to possess diverse activities. Zeorin (1) and atranorin (2) exhibited antidiabetic and antioxidant activities [6]. Compound 1 exhibited strong antibacterial and antifungal activities [7].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents of Moss Macromitrium orthostichum Nees ex Schwägr.

Ragasa¹,

Tan²,

Linis³

et al. 2019

Asian J. Chem.

View full text Add to dashboard Cite

INTRODUCTION Macromitrium Brid. is a large genus of pantropical mosses consisting of xerophytic epiphytes. One member of this genus, M. orthostichum Nees ex Schwägr. is restricted in Southeast Asia up to Papua New Guinea was recorded in Luzon, Mindoro and Mindanao islands in the Philippines [1]. Like other members of Macromitrium, this species is distinguished from other mosses by having creeping prostrate stems that give rise to rigid branches that terminate into sporophytes [2]. The plant of Macromitrium orthostichum, as in most members of Macromitrium, have some shades of reddish brown with leaves variously twisted and contorted around the branches. Macromitrium orthostichum differs from other Macromitrium species by having papillose rhizoids arising along the basal leaf margins [3]. There is no report on the chemical constituents and biological activities of Macromitrium orthostichum. Herein, the isolation of zeorin (1), atranorin (2) and a mixture of β-sitosterol (3) and stigmasterol (4) (Fig. 1) from the dichloromethane extract of Macromitrium orthostichum is reported. To the best of our knowledge, this is the first report on the isolation of compounds 1-4 from Macromitrium orthostichum.

show abstract

Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review

Cited by 42 publications

References 56 publications

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.

α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense

Chemical Constituents of Moss Macromitrium orthostichum Nees ex Schwägr.

Contact Info

Product

Resources

About