<i>Penicillium viridicatum</i> Westling: a new source of ochratoxin A

Walbeek, W. van; Scott, P. M.; Harwig, J.; Lawrence, Jeffry B.

doi:10.1139/m69-232

Cited by 109 publications

(33 citation statements)

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“…Four years later, van Walbeek, Scott, Harwig, and Lawrence (1969) isolated the same compound from Penicillium verrucosum. OTA was described as one of the first group of fungal metabolites that are toxic to animals, which, with the aflatoxins, launched the distinctive and diverse science of mycotoxicology in the 1960s.…”

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confidence: 99%

Pressurized liquid extraction coupled to liquid chromatography for the analysis of ochratoxin A in breakfast and infants cereals from Morocco

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Pressurized liquid extraction coupled to liquid chromatography for the analysis of ochratoxin A in breakfast and infants cereals from Morocco

et al. 2010

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“…The most toxic of the group, ochratoxin A, is a potent nephrotoxin elaborated by A . ochraceus [19,391, P. viridicatum [40], and other species of Aspergillus [19,231 and Penicillium [l 13. Fungi that produce ochratoxin are common contaminants of stored grains, and the natural occurrence of ochratoxin A in corn and wheat has been reported [32,331.…”

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Ochratoxin A Toxicosis in Swine

et al. 1973

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Abstract. Ochratoxicosis was induced in young female swine by a diet contaminated with a rice culture of Aspergillus ostiantrs that contained ochratoxin A and by daily oral doses of 2.0 or I .O mg/kg body weight pure ochratoxin A. Mycotoxicosis was characterized early by depression and reduction in feed intake and loss of body weight, followed by diarrhea, polyuria, polydipsia and dehydration. The pigs given pure ochratoxin A were dead or moribund in 5 to 6 days. Packed cell volume, hemoglobin, total plasma protein, and blood urea nitrogen were increased. Progressive leukocytosis, neutrophilia and moderate left shift in the differential count occurred. Concentrations of lactic dehydrogenase, isocitric dehydrogenase and glutamic-oxalacetic transaminase in the serum and urine were increased by the fourth to sixth day, but only the increase in urinary concentrations was significant. Gross findings included dehydration, enteritis, pale tan discoloration of the liver, and edema and hyperemia of the mesenteric and other lymph nodes. Microscopic lesions were most frequent and severe in the kidney and gastrointestinal tract. Necrosis of renal tubular epithelium was most frequent in the convoluted tubules. Many renal tubules were dilated. The intestinal lesions were focal and necrotizing and occurred in most anatomic regions. Fatty change was demonstrated in most of the livers. In lymphoid tissues the changes were edema, hyperemia and focal necrosis of lymphocytes within germinal centers and around follicles.

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“…Ochratoxins, the principal one of which is ochratoxin A, are fungal metabolites first isolated from Aspergillus ochraceus [33] and later identified as metabolites of Penicillium viridicatum [34] and other members of the A . ochraceus group [13,191.…”

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Ochratoxicosis in Beagle Dogs. II. Pathology

1973

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(With 1 color plate)Absruact. The gross lesions in 23 young male Beagle dogs given daily oral doses of 0.2-3.0 nig/kg body weight ochratoxin A consisted of moderate to severe niucohemorrhagic enteritis of the cecum, colon, and rectum; tonsillitis; and enlargement of lymph nodes, which were edematous, hyperemic, and focally necrotic. Histopathologic alterations in the kidneys consisted of necrosis and desquamation of epithelial cells mainly in, but not limited to, proximal convoluted tubules. Many proximal and distal convoluted tubules contained eosinophilic, granular casts. Necrosis of lymphoid tissues was a prominent feature of the niycotoxicosis and focally occurred in, but was not limited to, germinal centers in the spleen, tonsils, thymus, and lymph nodes and the lymphoid nodules of the jejunum, ileum, cecum, colon, rectum and nictitating membrane. Necrosis did not occur in bone marrow. Hepatic alterations consisted of slight to moderate centrilobular necrosis and fatty change and occurred mainly in dogs receiving 0.2-0.3 mg/kg body weight ochratoxin A daily for 11-14 days.In a companion paper [30], we described the clinical and clinicopathologic features of ochratoxicosis in Beagle dogs. Ochratoxins, the principal one of which is ochratoxin A, are fungal metabolites first isolated from Aspergillus ochraceus [33] and later identified as metabolites of Penicillium viridicatum [34] and other members of the A . ochraceus group [13, 191. The pathologic changes produced by ochratoxin A have been studied in the duckling [26,32], rat [23, 25, 27, 28, 321, chick [3, 10, 241 and trout 191. In the species studied, ochratoxicosis is characterized by renal and hepatic damage and alterations in the intestinal and lymphoid tissues. The severity of the lesions varies somewhat with species and dose of ochratoxin.The present report describes the gross and microscopic pathologic alterations produced in dogs by either an ochratoxin-A-containing rice culture of A . ochraceus or commercial ochratoxin A.

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Penicillium viridicatum Westling: a new source of ochratoxin A

Cited by 109 publications

References 0 publications

Pressurized liquid extraction coupled to liquid chromatography for the analysis of ochratoxin A in breakfast and infants cereals from Morocco

Pressurized liquid extraction coupled to liquid chromatography for the analysis of ochratoxin A in breakfast and infants cereals from Morocco

Ochratoxin A Toxicosis in Swine

Ochratoxicosis in Beagle Dogs. II. Pathology

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