<i>Perilla frutescens</i>Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity

Choi, Soo Jung; Oh, Seungsang; Kim, Cho Rong; Kwon, Yoon Kyung; Suh, Soo Hwan; Kim, Jae Kyeom; Park, Gwi Gun; Son, Seung-Yeol; Shin, Dong‐Hoon

doi:10.1089/jmf.2015.3540

Cited by 18 publications

(6 citation statements)

References 22 publications

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“…TMT induces neuronal degeneration in the hippocampus, and results in behavioral alterations, including cognitive impairment. TMT has been widely used as a neurotoxin based on its in vivo behavioral changes and biochemical effects in the brain [9]. In agreement with many other previous studies, our study confirmed that TMT induced learning and memory impairment in mice.…”

Section: Ache Activity and Ach Content In Mouse Brain Tissuesupporting

confidence: 92%

Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment

Seo

Choi

Park

et al. 2018

Food Sci Biotechnol

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Many edible plant extracts exhibit biological activities. For example, the ethanol extract of Pueraria montana var. lobata (P. montana) inhibits acetylcholinesterase (AChE), and red ginseng is well known for promoting health. In this study the authors investigated the synergistic effect of P. montana and red ginseng extracts on AChE activity in vitro and in mouse brain tissues and trimethyltin (TMT)-induced cognitive impairment in a mouse model of TMT-induced neurodegeneration. A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments in Y-maze and passive avoidance behavioral tests. In addition, the mixture inhibited AChE activity and lipid peroxidation synergistically.

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Section: Ache Activity and Ach Content In Mouse Brain Tissuesupporting

confidence: 92%

Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment

Seo

Choi

Park

et al. 2018

Food Sci Biotechnol

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“…Perilla is a self-pollinating plant and widely distributed in East Asian countries and considered as a food supply and natural medicine resource [ 1 , 2 ]. Perilla frutescens belongs to the Lamiaceae family and encompasses many natural varieties [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

Liao

Hao

et al. 2018

BMC Genomics

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BackgroundPerilla frutescens is well known for its high α-linolenic acid (ALA) accumulation in seeds and medicinal values as well as a source of edible and general-purpose oils. However, the regulatory mechanisms of the biosynthesis of fatty acid in its seeds remain poorly understood due to the lacking of sequenced genome. For better understanding the regulation of lipid metabolism and further increase its oil content or modify oil composition, time-course transcriptome and lipid composition analyses were performed.ResultsAnalysis of fatty acid content and composition showed that the α-linolenic acid and oleic acid accumulated rapidly from 5 DAF to 15 DAF and then kept relatively stable. However, the amount of palmitic acid and linoleic acid decreased quickly from 5 DAF to 15DAF. No significant variation of stearic acid content was observed from 5 DAF to 25DAF. Our transcriptome data analyses revealed that 110,176 unigenes were generated from six seed libraries at 5, 10, 20 DAF. Of these, 53 (31 up, 22 down) and 653 (259 up, 394 down) genes showed temporal and differentially expression during the seed development in 5 DAF vs 10 DAF, 20 vs 10 DAF, respectively. The differentially expressed genes were annotated and found to be involved in distinct functional categories and metabolic pathways. Deep mining of transcriptome data led to the identification of key genes involved in fatty acid and triacylglycerol biosynthesis and metabolism. Thirty seven members of transcription factor family AP2, B3 and NFYB putatively involved in oil synthesis and deposition were differentially expressed during seed development. The results of qRT-PCR for selected genes showed a strong positive correlation with the expression abundance measured in RNA-seq analysis.ConclusionsThe present study provides valuable genomic resources for characterizing Perilla seed gene expression at the transcriptional level and will extend our understanding of the complex molecular and cellular events of oil biosynthesis and accumulation in oilseed crops.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-4595-z) contains supplementary material, which is available to authorized users.

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“…Similar to the results of α‐glucosidase inhibitory, the AChE inhibitory was only significantly related to TPC ( r = −0.605, p < .05) and FRAP ( r = −0.647, p < .05), while the correlations to TFC, DPPH scavenging activity, and ABTS + scavenging ability were all not significant ( p > .05). The reason might be that although phenolic compounds, especially rosmarinic acid was identified as the major AChE inhibitor in P. frutescens (Choi et al., 2016), other uncharacterized components in this study, including perilla aldehyde, water‐soluble components, and others, also played important role in the AChE inhibitory (Park et al., 2016; Um et al., 2013), and they had different correlations with antioxidant activities.…”

Section: Resultsmentioning

confidence: 78%

The influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract: Changes in the active compounds and bioactivities

Wang

et al. 2020

J. Food Biochem.

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In this study, the influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract (PFLE) were measured. Results revealed that total phenolic content (TPC) and total flavonoid content (TFC) were significantly decreased after simulated digestion (ca. 53% of phenolics and 40% of flavonoids). The IC 50 value of DPPH• scavenging activity and ABTS + scavenging ability increased by 23% and 56%, respectively, while ferric reducing antioxidant power reduced by 53%. For the inhibition ability on α-glucosidase, acetylcholinesterase, and MCF-7 cell proliferation, their IC 50 values increased by 360%, 197%, and 25%, respectively. Three phenolic acids and one flavonoid in PFLE were quantified by high-performance liquid chromatography. Overall, although significant losses of the active components and biological activities occurred during in vitro gastrointestinal digestion, it still showed the potential as an oral agent for treatment and prevention of oxidative stress, cancer, diabetes, and Alzheimer's disease. Practical applications As an important annual herbaceous plant with rich biochemical compounds and many biological functions, Perilla frutescens leave is widely used in the food and traditional Chinese medicine. However, the dynamic changes of its active compounds and activities during the digestion process are unclear. In this study, the digestion results in significant loss of the active ingredients and biological activities of P. frutescens leaf extract (PFLE), particularly in the gastric digestion. In addition, PFLE remains to show certain antioxidant activity, α-glucosidase inhibitory ability, acetylcholinesterase inhibitory ability, and MCF-7 cell proliferation inhibitory ability after digestion.

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Perilla frutescensExtract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity

Cited by 18 publications

References 22 publications

Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment

Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment

Transcriptomic analysis of Perilla frutescens seed to insight into the biosynthesis and metabolic of unsaturated fatty acids

The influence of in vitro gastrointestinal digestion on the Perilla frutescens leaf extract: Changes in the active compounds and bioactivities

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