Pistacia atlanticaResin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat

Abstract

Objectives. The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing. Methods. Thirty-two Wistar rats were divided into four groups and treated by vehicle, 5%, 10%, and 20% concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3, and G4, resp.). The efficacy of treatment was assessed based on reduction of burn wound size and histological and molecular characteristics. Results. α-Pinene (46.57%) was the main content of essential oil of resin. There were no statistically significant differences between groups according to wound size analysis. The mean histological wound healing scores were not statistically different. Capillary counts of G2 and G3 were significantly higher than those of the G1 (P = 0.042 and 0.032, resp.). NO concentration in wound fluids on the 5th day of study was not significantly different between groups (P = 0.468). But bFGF concentration in G2 and G3 and PDGF concentration in G3 were significantly higher in comparison to G1 (P = 0.043, 0.017, and 0.019, resp.). Conclusion. Our results revealed that Pistacia atlantica resin extract has a concentration-dependent effect on the healing of burn wounds after 14 days of treatment by increasing the concentration of bFGF and PDGF and also through improving the angiogenesis.

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

“…The second compound in abundance is probably β-phellandrene (SI 68%), which has been identified in the EO of pine species, such as Juniperus formosana [19], as well as the EO of Zanthoxylum bungeanum, an oil that has potential in the treatment of psoriasis [26]. α-Pinene is the main constituent of the Pistacia atlantica resin, which has been proven to treat burn wounds, showing an increased concentration of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) and also increased angiogenesis [27]. In addition, α and β-pinene are present in the Salvia officinalis EO composition and have in vitro anti-inflammatory activity due to inhibited nitric oxide (NO) production in mouse macrophages [28].…”

The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats

“…The percentage of wound contraction at each time point was derived by the following formula: wound contraction percentage ¼ (initial wound area − current wound area)/initial wound area  100 %. Epithelialization period was evaluated as the number of days for each scar to vanish and it must be noted that no raw wound left behind as it was monitored [5,11,[26][27][28].…”

Herbal prevention and treatment of nipple trauma and/or pain in Iranian studies: a systematic review

“…Saqez contains α-pinene and triterpenoid compounds with strong antimicrobial and antioxidant properties and thus cures wounds. The ointment of Saqez, melted with tallow, is effective in the treatment of bursting nails and chronic anal fissure (24)(25)(26). As̕ adi et al showed that Saqez ointment was more effective in the treatment of nipple fissures and pain than breast milk.…”