<i>Plasmodium knowlesi</i>Malaria in Humans and Macaques, Thailand

Jongwutiwes, Somchai; Buppan, Pattakorn; Kosuvin, Rattiporn; Seethamchai, Sunee; Pattanawong, Urassaya; Sirichaisinthop, Jeeraphat; Putaporntip, Chaturong

doi:10.3201/eid1710.110349

Cited by 112 publications

(120 citation statements)

References 32 publications

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“…Because the initial blood smears of the patient contained various stages of malaria with unusually high parasite density, nested polymerase chain reaction analyses targeting the 18S rRNA and the mitochondrial cytochrome b genes of human malaria species were performed as previously described. 4,5 Results of these assays confirmed that the patient was infected with P. knowlesi.…”

Section: Case Reportsupporting

confidence: 50%

“…It is noteworthy that all these knowlesi malaria patients, either having monoor mixed species infections, had uncomplicated symptoms and were responsive to chloroquine and a combination of artesunate and mefloquine. [4][5][6] Herein, we describe severe manifestations of knowlesi malaria in a newly recognized Thai patient.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 In Thailand, P. knowlesi contributes to 1% of all malaria cases based on large epidemiological surveys using molecular detection methods. 4,5 Of these, 70% of knowlesi malaria patients were co-infected with P. falciparum, Plasmodium vivax, or both. It is noteworthy that all these knowlesi malaria patients, either having monoor mixed species infections, had uncomplicated symptoms and were responsive to chloroquine and a combination of artesunate and mefloquine.…”

Section: Introductionmentioning

confidence: 99%

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An Autochthonous Case of Severe Plasmodium knowlesi Malaria in Thailand

Nakaviroj¹,

Kobasa²,

Teeranaipong³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract.A 58-year-old Thai man was infected with Plasmodium knowlesi in Chantaburi Province, eastern Thailand. In addition to pyrexia, the patient developed hypotension, renal failure, jaundice, and severe thrombocytopenia. The parasitemia at the time of admission was 16.67% or~503,400 parasites/μL. With artesunate treatment and supportive care, the patient recovered uneventfully. The occurrence of complicated knowlesi malaria in a low-endemic area underscores the risk of high morbidity from this simian malaria.

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Section: Case Reportsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Autochthonous Case of Severe Plasmodium knowlesi Malaria in Thailand

Nakaviroj¹,

Kobasa²,

Teeranaipong³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…All these reports suggest that P. knowlesi infections in humans are wide spread in South-east Asia. Retrospective analysis of malaria cases identified by microscopy more than 10-12 years back in Malaysian Borneo ( (Lee et al 2009b) and Tak province in Thailand (Jongwutiwes et al 2011) found P. knowlesi infections among them. These studies suggest that P. knowlesi is not a new emergent simian malaria parasite in humans, and it was present in humans prior to Singh et al (2004) report.…”

Section: Natural P Knowlesi Infections In Humansmentioning

confidence: 99%

Centenary celebrations article

Subbarao

2011

J Parasit Dis

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The identification of a large focus of Plasmodium knowlesi in Malaysian Borneo and subsequent reports from several countries in South-east Asia has led its recognition as the fifth human malaria parasite. The natural preferred hosts of this species still continue to be macaque monkeys that live in broad-leaf rain forests. This review describes the distribution of macaque monkeys, the Anopheles species belonging to the Leucosphyrus Group that have been incriminated as vectors, morphological and clinical features of this parasite, and the transmission cycles that have been identified for this parasite. As the North-eastern states of India share their borders with P. knowlesi malaria endemic countries and because travelers from countries in South-east Asia visit India and vice versa, risks of this parasite entering India and its spread are also discussed.

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“…Plasmodium vivax has been described as the benign form of malaria, yet many case reports showed that vivax malaria remains responsible for severe clinical manifestations and mortality in vivax-endemic areas (4). Knowlesi-infection is widely distributed in South East Asian countries (5)(6)(7)(8)(9) and could lead to hyperparasitemia in a short period as P. knowlesi has the fastest life cycle of 24 hours among the human Plasmodium sp. (10).…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity of the Merozoite Surface Protein-1 (Msp-1) of Human Plasmodium Sp.

Yl¹,

Fw²,

My³

2015

JUMMEC

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Malaria is a major cause of mortality and morbidity globally. Great efforts have been made in the prevention and the elimination of malaria, especially in controlling the malaria vector, the mosquito. Another promising approach would be the development of malaria vaccines. Malaria vaccine studies can be focused on the pre-erythrocytic-stage antigens and the blood-stage antigens, and on the transmission blocking agents targeting the malaria gametocytes. The blood-stage antigens are the leading candidates in malaria vaccine development, as the blood-stage parasites are responsible for causing symptomatic malaria. Human acquired immunity largely targets on blood-stage antigens. This review focuses on one of the most extensively studied blood-stage antigen, the merozoite surface protein-1 (MSP-1), specifically on its evaluation and immunogenicity in rodents and primate models, and its safety and immunogenicity in human clinical trials.

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Plasmodium knowlesiMalaria in Humans and Macaques, Thailand

Abstract: This parasite may be transmitted from macaques to humans.

Cited by 112 publications

References 32 publications

An Autochthonous Case of Severe Plasmodium knowlesi Malaria in Thailand

An Autochthonous Case of Severe Plasmodium knowlesi Malaria in Thailand

Centenary celebrations article

Immunogenicity of the Merozoite Surface Protein-1 (Msp-1) of Human Plasmodium Sp.

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