Pleurotus eryngii Ameliorates Lipopolysaccharide‐Induced Lung Inflammation in Mice

Abstract

Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects. We investigated the anti-inflammatory effect of P. eryngii in mice with acute lung injury (ALI). Intranasal instillation of lipopolysaccharide (LPS) (10 μg/site/mouse) induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid) as well as histopathological damage in the lung, 6 h after treatment. Mice administered heat-treated P. eryngii (0.3–1 g/kg, p.o. (HTPE)) 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage. These results suggest that HTPE has anti-inflammatory effects against ALI. Thus, P. eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection.

Fermentation Supernatants of Pleurotus eryngii Mushroom Ameliorate Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide-Induced Caco-2 Cells via Upregulation of Tight Junctions

“…P. eryngii , also known as the king oyster mushroom, is widely consumed as functional food and displays multiple biological functions due to its variety of bioactive components. Among these substances, polysaccharides extracted from P. eryngii have been shown to exhibit antitumor, antioxidant, hepatoprotective, hypolipidemic, anti-obesity and anti-inflammatory activities [ 16 , 50 , 51 , 52 , 53 ]. A possible explanation for the preventive effect of P. eryngii mushrooms on impending intestinal barrier damage could be their high β-glucan content.…”

Application of Fungi as Meat Alternatives in Industry: Mini Review

“…eryngii is also commonly consumed by humans without any reported case of allergies or disease to human beings (Hu et al 2019). Daily consumption of P. eryngii is recommended because it has anti-inflammatory properties that can help prevent acute lung injury caused by a bacterial infection (Kawai et al 2014). Furthermore, consuming P. eryngii was reported to lower blood cholesterol in humans (Alam et al 2011).…”

Breeding of Pleurotus eryngii, "Aeryni 5"

“…큰느타리버섯(P. eryngii)은 맛과 향이 뛰어나고 대가 단 단하여 저장기간이 긴 특징을 가지고 있다 (Ryu et al, 2015). 또한, 에르고스테롤 (Jang et al, 2011)이나 간암세 포를 억제하는 활성을 지닌 다당류 (Kawai et al, 2014). 항산화활성, 항염증효과 (Lin et al, 2014), Angiotensin converting enzyme 저해활성 (Kang et al, 2003), 그리고 프로바이오틱 활성 (Synytsya et al, 2009) (Im et al, 2012a), 갓모양이 우수한 애린이 (Im et al, 2012b), 환경내성이 강하고 다수확 품종인 애린이3 , 저발이 특성을 가져서 솎음 작업을 경감시켜주는 단비 (Kim et al, 2012), 고온적응성이 우수한 태양송이 , 저장성이 우수한 단비5호 (Lee et al, 2016), 그리고 송아 (Shin et al, 2011), 곤지3호 (Ha et al, 2011) , 곤지8호 (Ha et al, 2013), 새곤지 (Ha et al, 2014), 설송 (Shin et al, 2013)…”