<i>Polygonum multiflorum</i>Thunb extract extended the lifespan and healthspan of<i>Caenorhabditis elegans via</i>DAF-16/SIR-2.1/SKN-1

Sun, Meng-Lu; Chen, Xinyan; Cao, Jinjin; Cui, Xin; Wang, Hongbing

doi:10.1039/d1fo01908b

Cited by 24 publications

(20 citation statements)

References 47 publications

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“…The stress tests usually include heat shock, ultraviolet light, and oxidative conditions. [28][29][30] Increased endogenic reactive oxygen species (ROS) further accelerate the aging process. 2,7-Dichlorodihydrofluorescein diacetate (H 2 DCF-DA), a fluorescent probe that reacts with ROS, is commonly used to reflect the in vivo ROS level.…”

Section: Introductionmentioning

confidence: 99%

“…31 Scientists use the mutants daf-2 (e1370) and daf-16 (mu86) to study whether the IIS pathway is involved in the drug-mediated longevity of worms, and use the TJ356 strain containing a GFP::DAF-16 transgene to determine the effect of drugs on DAF-16 subcellular localization. 28,30 Meanwhile, DAF-16 also interacts with SIR-2.1, a member of the sirtuin family of NAD + -dependent protein deacetylases. The mutant sir-2.1 (ok434) is also used in related studies.…”

Section: Introductionmentioning

confidence: 99%

“…28,34 Using the mutant skn-1 (zu135), researchers have found that Polygonum multiflorum extracts rely on the SKN-1/Nrf2 pathway to prolong lifespan. 30 Thus, the present study used C. elegans mutants daf-16 (mu86), daf-2 (e1370), sir-2.1 (ok434), and skn-1 (zu135) to study the potential antiaging mechanism of the new catechins.…”

Section: Introductionmentioning

confidence: 99%

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Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways

Gao

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways

Gao

et al. 2022

Food Funct.

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“…Schott. and others) and indolealkylamines 91 (from Veneum Bufonis ). Drosophila has also been used in anti‐inflammation research on Chinese medicine 90 .…”

Section: The Classical Experimental Model Of the Anti‐inflammatory Ef...mentioning

confidence: 99%

“…Drosophila has also been used in anti‐inflammation research on Chinese medicine 90 . In addition, a few studies of the effects of Chinese medicine ( Polygonum multiflorum Thun b extract) on inflammation also used Caenorhabditis elegans models 91 . Experimental models of the anti‐inflammatory effects of TCM are clearly not limited to rodents, and other model animal models also contribute to inflammatory disease assessment.…”

Section: The Classical Experimental Model Of the Anti‐inflammatory Ef...mentioning

confidence: 99%

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Hou

Guo

et al. 2022

Anim Models and Exp Med

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Inflammation is a common disease involved in the pathogenesis, complications, and sequelae of a large number of related diseases, and therefore considerable research has been directed toward developing anti‐inflammatory drugs for the prevention and treatment of these diseases. Traditional Chinese medicine (TCM) has been used to treat inflammatory and related diseases since ancient times. According to the review of abundant modern scientific researches, it is suggested that TCM exhibit anti‐inflammatory effects at different levels, and via multiple pathways with various targets, and recently a series of in vitro and in vivo anti‐inflammatory models have been developed for anti‐inflammation research in TCM. Currently, the reported classic mechanisms of TCM and experimental models of its anti‐inflammatory effects provide reference points and guidance for further research and development of TCM. Importantly, the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation‐related diseases.

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Comparison of metabolic differences between two geometrical isomers based on multi‐omics strategy

Ge,

Gao,

Zhang

et al. 2023

Separation Science Plus

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Abstract2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside is the main compound of Polygonum multiflorum. There are two geometrical isomers of 2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside. Several studies have shown that cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside may be the risk compound of hepatotoxicity in Polygonum multiflorum Thunb. and there are few comprehensive comparisons on the different impacts of cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside and trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside about metabolic characteristics. This paper aimed to provide a comprehensive assessment of the metabolomics and lipidomics studies of the differences in metabolic characteristics of cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside and trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside. The results showed that trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside and cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside significantly affected 47 metabolites. The main interfering pathways included alpha‐linolenic acid, linoleic acid (LA) metabolism, arachidonic acid (AA) metabolism, and fatty acid metabolism. According to the transcriptomics study, the altered genes were mainly enriched in LA metabolism, AA metabolism, and fatty acid metabolism. Two genes (Runx3 and Scd1) were mainly involved in the cell cycle and fatty acid metabolism in the cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside group, and one enzyme (Phospholipase B1) was related to alpha‐linolenic acid, LA metabolism and AA metabolism in the trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside group. These would provide useful information for further investigation on therapeutic and hepatotoxic mechanisms of Polygonum multiflorum Thunb.

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Polygonum multiflorumThunb extract extended the lifespan and healthspan ofCaenorhabditis elegans viaDAF-16/SIR-2.1/SKN-1

Abstract: PMT-E significantly extended the lifespan and healthspan of C. elegans in a DAF-16/SIR-2.1/SKN-1-dependent manner.

Cited by 24 publications

References 47 publications

Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways

Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Comparison of metabolic differences between two geometrical isomers based on multi‐omics strategy

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