<i>PON1</i>gene polymorphisms in patients with chronic obstructive pulmonary disease

Rajković, Marija Grdić; Popović‐Grle, Sanja; Dugac, Andrea Vukić; Rogić, Dunja; Rako, Ivana; Antolic, Margareta Radić; Beriša, Mirela; Rumora, Lada

doi:10.1136/jclinpath-2018-205194

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Of the 119 initially identified articles, 100 articles were excluded after screening of titles and abstracts. After screening of full-texts, six studies were excluded because six studies did not focus on PON1 activity of patients with COPD [ 22 , 23 , 24 , 25 , 26 , 27 ]. One study [ 28 ] was excluded because it included the same population as another study [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis

2021

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Oxidative stress is a driving factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). While paraoxonase 1 (PON1) is an antioxidant enzyme and a potential biomarker of this disease, data regarding the status of PON-1 in COPD are inconclusive. In this regard, to shed light on this issue, we performed a meta-analysis of data on PON1 activity in COPD. Electronic databases (MEDLINE, Embase and CENTRAL) were searched for available studies on PON1 activity in patients with stable COPD published before October 2021. A meta-analysis was performed using random-effects models. Twelve studies (12 studies on paraoxonase and three on arylesterase) were identified. Patients with COPD had lower levels of paraoxonase activity (standard mean difference [SMD] −0.77, 95% confidence interval [CI] −1.35 to −0.18) and arylesterase activity (SMD −1.15, 95% CI −1.95 to −0.36) in comparison to healthy controls. In subgroup analyses, paraoxonase activity was lower in patients of studies as consisted of mainly non-severe COPD (SMD −1.42, 95% CI −2.04 to −0.79) and, by contrast, slightly higher in patients of studies including severe COPD (SMD 0.33, 95% CI 0.02 to 0.64) in comparison to healthy controls. Arylesterase activity showed a similar trend. Overall, PON1 activity was lower in patients with COPD, suggesting that PON1-related antioxidant defense is impaired in COPD. Future studies are warranted.

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Section: Resultsmentioning

confidence: 99%

Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis

2021

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“…Lada et al reported that patients with COPD had lower PON1 activity compared with healthy subjects, 45 and they found that PON1 polymorphism could contribute to the reduction of PON1 activity in patients with COPD. 46 SEPTIN2 is a member of a highly conserved GTPase family. It was revealed that SEPTIN2 fundamentally regulated airway epithelial barrier function in response to pathological luminal stimuli by altering cortical actin expression.…”

Section: Discussionmentioning

confidence: 99%

Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease

Yang¹,

Li²,

Yang³

et al. 2023

COPD

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Background Frequent exacerbation (FE) and infrequent exacerbation (IE) are two phenotypes of chronic obstructive pulmonary disease (COPD), of which FE is associated with a higher incidence of exacerbation and a serious threat to human health. Because the pathogenesis mechanisms of FE are unclear, this study aims to identify FE-related proteins in the plasma via proteomics for use as predictive, diagnostic, and therapeutic biomarkers of COPD. Methods A cross-sectional study was conducted in which plasma protein profiles were analyzed in COPD patients at stable stage, and differentially expressed proteins (DEPs) were screened out between the FE and IE patients. FE-related DEPs were identified using data-independent acquisition-based proteomics and bioinformatics analyses. In addition, FE-related candidates were verified by enzyme-linked immunosorbent assay. Results In this study, 47 DEPs were screened out between the FE and IE groups, including 20 upregulated and 27 downregulated proteins. Key biological functions (eg, neutrophil degranulation, extracellular exosome, protein homodimerization activity) and signaling pathways (eg, arginine and proline metabolism) were enriched in association with the FE phenotype. Receiver operating characteristic (ROC) analysis of the 11 combined DEPs revealed an area under the curve of 0.985 ( p <0.05) for discriminating FE from IE. Moreover, correlation and ROC curve analyses indicated that creatine kinase, M-type (CKM) and fat storage-inducing transmembrane protein 1 (FITM1) might be clinically significant in patients with the FE phenotype. In addition, plasma expression levels of CKM and FITM1 were validated to be significantly decreased in the FE group compared with the IE group (CKM: p <0.01; FITM1: p <0.05). Conclusion In this study, novel insights into COPD pathogenesis were provided by investigating and comparing plasma protein profiles between the FE and IE patients. CKM, FITM1, and a combinative biomarker panel may serve as useful tools for assisting in the precision diagnosis and effective treatment of the FE phenotype of COPD.

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“…In the lung, PON1 has been detected through immunohistochemical evidence in type 1 pneumocytes, but its physiological role in the context of lung antioxidant activity has not yet been described [ 97 ]. However, there are a few publications on the role of PON1 activity in patients with asthma and COPD [ 98 , 99 , 100 ] and on its impact on lung cancer behavior and progression by antioxidative function and controlled ROS accumulation [ 101 ].…”

Section: Diminished Antioxidant Defensesmentioning

confidence: 99%

The Role of Oxidative Stress in Sarcoidosis

Fois

Canu

Fois

2021

IJMS

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Sarcoidosis is a rare, systemic inflammatory disease whose diagnosis and management can pose a challenge for clinicians and specialists. Scientific knowledge on the molecular pathways that drive its development is still lacking, with no standardized therapies available and insufficient strategies to predict patient outcome. In recent years, oxidative stress has been highlighted as an important factor in the pathogenesis of sarcoidosis, involving several enzymes and molecules in the mechanism of the disease. This review presents current data on the role of oxidative stress in sarcoidosis and its interaction with inflammation, as well as the application of antioxidative therapy in the disease.

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PON1gene polymorphisms in patients with chronic obstructive pulmonary disease

Abstract: Higher frequency of TT genotype and T allele could contribute to the observed reduction of PON1 activity in patients with COPD. T allele and TT genotype are associated with COPD, and the -108C>T polymorphism could be a potential predictor of the disease.

Cited by 6 publications

References 38 publications

Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease

The Role of Oxidative Stress in Sarcoidosis

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