PPARGC1A rs3736265 G&gt;A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level

Zhu, Li; Huang, Qiuyu; Xie, Zhiqiang; Kang, Mingqiang; Ding, Hao; Chen, Boyang; Chen, Yu; Liu, Chao; Wang, Yafeng; Tang, Weifeng

doi:10.18632/oncotarget.16307

Cited by 17 publications

(7 citation statements)

References 38 publications

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“…SHEsis software ( http://analysis.bio-x.cn/myanalysis.php ; Bio-X, Shanghai, China) was used online to construct the haplotypes. 22 – 24 …”

Section: Methodsmentioning

confidence: 99%

The relationship between IGF2BP2 and PPARG polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

Qiu¹,

Wang²,

Kang³

et al. 2017

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The aim of this case–control study was to assess whether PPARG and IGF2BP2 polymorphisms confer susceptibility to esophageal squamous-cell carcinoma (ESCC). A total of 507 patients pathologically confirmed for ESCC and 1,496 age-, sex-, and residence-matched healthy individuals were enrolled. The PPARG rs1801282 C>G and rs3856806 C>T and IGF2BP2 rs1470579 A>C and rs4402960 G>T polymorphisms were selected and genotyped by SNPscan genotyping assays. Multivariable logistic analysis suggested that the PPARG rs3856806 C>T polymorphism might increase the risk of ESCC. In different stratified analyses, there were significant associations between PPARG rs3856806 C>T and risk of ESCC in female, never-smoking, drinking, and never-drinking subgroups. In addition, we also found that PPARG rs1801282 C>G increased ESCC risk in the never-smoking subgroup. There was significant difference in Crs1470579Grs4402960Crs1801282Crs3856806-haplotype distribution among ESCC cases and control subjects. In conclusion, our findings highlight that PPARG rs1801282 C>G and rs3856806 C>T polymorphisms are candidates for susceptibility to ESCC in the eastern Chinese Han population. The Crs1470579Grs4402960Crs1801282Crs3856806 haplotype is associated with susceptibility to ESCC.

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“…SHEsis software ( http://analysis.bio-x.cn/myanalysis.php ; Bio-X, Shanghai, China) was used online to construct the haplotypes. 22 – 24 …”

Section: Methodsmentioning

confidence: 99%

The relationship between IGF2BP2 and PPARG polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

Qiu¹,

Wang²,

Kang³

et al. 2017

OTT

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“…A meta-analysis has also identified 24 genetic variants in 16 genes as being associated with DN [5]. T2DM has also become the most prevalent metabolic disease globally being a multifactorial disorder as a result of the interaction of the environmental factors with the individual's genetic background [13]. Some common examples of genes which link oxidative stress to diabetic nephropathy are carnosinase, endothelial nitric oxide synthase, and manganese superoxide dismutase genes.…”

Section: Introductionmentioning

confidence: 99%

CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia

Yahya

Ismail

Nordin

et al. 2019

Journal of Nutrition and Metabolism

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Type 2 diabetes mellitus (T2DM) is associated with a high incidence of nephropathy. The aim of this study was to investigate the association of a genetic polymorphism of carnosinase (CNDP1-D18S880 and -rs2346061), endothelial nitric oxide synthase (NOS3-rs1799983), and manganese superoxide dismutase (MnSOD-rs4880) genes with the development of diabetic nephropathy among Malaysian type 2 diabetic patients. A case-control association study was performed using 652 T2DM patients comprising 227 Malays (without nephropathy = 96 and nephropathy = 131), 203 Chinese (without nephropathy = 95 and nephropathy = 108), and 222 Indians (without nephropathy = 136 and nephropathy = 86). DNA sequencing was performed for the D18S880 of CNDP1, while the rest were tested using DNA Sequenom MassARRAY to identify the polymorphisms. DNA was extracted from the secondary blood samples taken from the T2DM patients. The alleles and genotypes were tested using four genetic models, and the best mode of inheritance was chosen based on the least p value. The rs2346061 of CNDP1 was significantly associated with diabetic nephropathy among the Indians only with OR = 1.94 and 95% CI = (1.76–3.20) and fitted best the multiplicative model, while D18S880 was associated among all the three major races with the Malays having the strongest association with OR = 2.46 and 95% CI = (1.48–4.10), Chinese with OR = 2.26 and 95% CI = (1.34–3.83), and Indians with OR = 1.77 and 95% CI = (1.18–2.65) in the genotypic multiplicative model. The best mode of inheritance for both MnSOD and NOS3 was the additive model. For MnSOD-rs4880, the Chinese had OR = 2.8 and 95% CI = (0.53–14.94), Indians had OR = 2.4 and 95% CI = (0.69–2.84), and Malays had OR = 2.16 and 95% CI = (0.54–8.65), while for NOS3-rs1799983, the Indians had the highest risk with OR = 3.16 and 95% CI = (0.52–17.56), followed by the Chinese with OR = 3.55 and 95% CI = (0.36–35.03) and the Malays with OR = 2.89 and 95% CI = (0.29–28.32). The four oxidative stress-related polymorphisms have significant effects on the development of nephropathy in type 2 diabetes patients. The genes may, therefore, be considered as risk factors for Malaysian subjects who are predisposed to T2DM nephropathy.

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“…Among the remaining 41 pieces of literature, after reading the full text, 25 literature pieces were excluded, which included two reviews, four meta analyses, 11 literature items with incomplete data, four literature items that did not study the gene polymorphic locus, one literature piece with suspected data duplication, and three literature items that studied diseases that were not T2DM. Finally, a total of 16 pieces of literature were included in the present meta-analysis [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. The entire retrieval process is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Correlation between PPARGC1A gene rs8192678 G>A polymorphism and susceptibility to type-2 diabetes

Yang

2019

Open Life Sciences

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ObjectiveTo systematically investigate the correlation between the G>A polymorphism of the peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A or PGC-1alpha) gene rs8192678 locus and the susceptibility to type-2 diabetes mellitus (T2DM).MethodsThe inclusion and exclusion criteria and retrieval strategies of original literatures were formulated. Then, subjects and free words “PPARGC1A”,”gene polymorphism”, and “T2DM” were retrieved from the PubMed, EMBASE, and Cochrane Library databases. Case-control studies on the G>A polymorphism of the PPARGC1A gene rs8192678 locus and susceptibility to T2DM were included for the meta-analysis.ResultsThe number of cases in the T2DM group and control group was 5,607 and 7,596, respectively. The meta-analysis revealed that the PPARGC1A gene rs8192678 locus G>A polymorphism is associated with susceptibility to T2DM. There are differences in each group of genetic models, of which three groups of genetic models are highly significant. In the allele model, OR=1.249, 95% CI: 1.099-1.419, and P=0.001. In the dominant inheritance model, OR=1.364, 95% CI: 1.152-1.614, and P=0.000. In the additive inheritance model, OR=0.828, 95% CI: 0.726-0.945, and P=0.005. And one group is significant, in the recessive inheritance model, OR=1.187, 95% CI: 1.021-1.381, and P=0.026.ConclusionIn Western Asian, South Asian, European and African populations, the A allele of the PPARGC1A gene rs8192678 locus may be one of the risk factors for T2DM.

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PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level

Cited by 17 publications

References 38 publications

The relationship between <em>IGF2BP2</em> and <em>PPARG</em> polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

The relationship between <em>IGF2BP2</em> and <em>PPARG</em> polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia

Correlation between PPARGC1A gene rs8192678 G>A polymorphism and susceptibility to type-2 diabetes

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