The relationship between <em>IGF2BP2</em> and <em>PPARG</em> polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population

Abstract

The aim of this case–control study was to assess whether PPARG and IGF2BP2 polymorphisms confer susceptibility to esophageal squamous-cell carcinoma (ESCC). A total of 507 patients pathologically confirmed for ESCC and 1,496 age-, sex-, and residence-matched healthy individuals were enrolled. The PPARG rs1801282 C>G and rs3856806 C>T and IGF2BP2 rs1470579 A>C and rs4402960 G>T polymorphisms were selected and genotyped by SNPscan genotyping assays. Multivariable logistic analysis suggested that the PPARG rs3856806 C>T polymorphism might increase the risk of ESCC. In different stratified analyses, there were significant associations between PPARG rs3856806 C>T and risk of ESCC in female, never-smoking, drinking, and never-drinking subgroups. In addition, we also found that PPARG rs1801282 C>G increased ESCC risk in the never-smoking subgroup. There was significant difference in Crs1470579Grs4402960Crs1801282Crs3856806-haplotype distribution among ESCC cases and control subjects. In conclusion, our findings highlight that PPARG rs1801282 C>G and rs3856806 C>T polymorphisms are candidates for susceptibility to ESCC in the eastern Chinese Han population. The Crs1470579Grs4402960Crs1801282Crs3856806 haplotype is associated with susceptibility to ESCC.

Long Non-Coding RNA CCAT2 Promotes the Development of Esophageal Squamous Cell Carcinoma by Inhibiting miR-200b to Upregulate the IGF2BP2/TK1 Axis

“…To further investigate such a developing pathway, we profiled the downstream genes of miR-200b through miRWalk, of which IGF2BP2 stood out as a potential target involved in the regulating pathway of ESCC. The underlying rationale here is that IGF2BP2 expression was reported to be upregulated in ESCC (10), which was also verified by the present GEPIA analysis, RT-qPCR, and immunoblotting results. The impact of IGF2BP2 expression on the biological characteristics of ESCC cells was recently reported (23), and our present results of scratch and Transwell assays concur with that result, in displaying that CCAT2 upregulated the expression of IGF2BP2 by adsorbing miR-200b in ESCC cells to promote their migration and invasion capacity.…”

“…However, whether or how CCAT2 regulates miR-200b in the progression of ESCC remains unknown. Moreover, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is reported to be oncogene, which is highly related to ESCC ( 10 ), and furthermore the abnormal expression of thymidine kinase 1 (TK1) is regarded as an important clinical characteristic in patients with ESCC ( 11 ). As such, it seems plausible that both IGF2BP2 and TK1 are involved in the signaling axis initiated by CCAT2.…”

Relationship between <em>IGF2BP2</em> and <em>IGFBP3</em> polymorphisms and susceptibility to non-small-cell lung cancer: a case&ndash;control study in Eastern Chinese Han population

“…To assess the relationship between IGF2BP2 and IGFBP3 SNPs and NSCLC risk, we selected polymorphisms in IGF2BP2 and IGFBP3 gene according to the publications, which were associated with the development of cancer. 12 , 13 , 19 – 21 …”

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

“…Multivariate logistic analyses have demonstrated that IGF2BP2 rs1470579 and rs4402960 polymorphisms increase the risk of developing esophageal squamous-cell carcinoma [ 78 ]. In contrast, a separate research showed that IGF2BP2 rs1470579 phenotype decreases the risk of developing esophagogastric junction adenocarcinoma in Eastern Chinese Han population [ 79 ].…”