Retracted: Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Upregulating miR‐141‐3p

Abstract

Alpinumisoflavone (AIF) as a principal active ingredient of traditional Chinese herb Derris eriocarpa exerts a broad spectrum of anticancer activities against solid tumors. However, little is known about the effect of AIF on papillary thyroid cancer (PTC). Objectives of this study are to investigate the effect of AIF on cell growth, apoptosis, and metastasis of PTC cells and uncover its underlying mechanisms. Results showed that AIF treatment notably suppressed cell viability, migration, invasion, and epithelial–mesenchymal transition (EMT) process, as well as induced apoptotic cell death. In addition, microarray analysis results revealed that miR‐141‐3p level was dramatically elevated upon AIF insulation, suggesting that miR‐141‐3p may mediate the suppressive role of AIF against PTC. Moreover, miR‐141‐3p knockdown effectively reversed the effects of AIF on cell growth, migration, invasion, and EMT, while promoted PTC cell apoptosis escape. Furthermore, in vivo findings also confirmed that the antigrowth and antimetastasis activities of AIF were, at least partly, mediated by upregulation of miR‐141‐3p. Overall, AIF could serve as a potential anticancer compound for PTC treatment. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:1842–1850, 2020. © 2019 American Association for Anatomy

RETRACTED:Alpinumisoflavone triggers GSDME‐dependent pyroptosis in esophageal squamous cell carcinomas

“…A number of flavonoid compounds have been reported to enhance the sensitivity of ESCC to chemotherapy or radiotherapy. As one of the most active ingredients of Derris Eriocarpa, AIF showed antiapoptosis effect in a variety of human malignancies including ESCC (Fang et al, 2019; Gao, Chang, Wang, Ban, & Zhang, 2017; Han et al, 2016; Li et al, 2019; Wang et al, 2017; Zhao, Zhang, Jiang, & Gao, 2019). We found that AIF was capable to increase the radiation sensitivity of ESCC cells, which was also validated in in vivo study.…”

“…Diverse pharmacological activities of AIF including atheroprotective (Ateba et al, 2019), estrogenic (Mvondo, Njamen, Tanee Fomum, & Wandji, 2012), and antibacterial (Chukwujekwu, Van Heerden, & Van Staden, 2011) have been reported. Furthermore, the role of AIF as a potential antineoplastic agent has also been reported (Fang, Liu, Liu, & Qian, 2019). Our previous work also showed that AIF could increase the sensitivity of ESCC cells to irradiation (Zhang, Fan, Wang, Zhu, & Li, 2017).…”

Long noncoding RNA ZEB1-AS1 acts as a Sponge of miR-141-3p to Inhibit Cell Proliferation in Colorectal Cancer

“…The luciferase reporter assay further verified our speculation that miR-141-3p is a target of ZEB1-AS1. MiR-141-3p is a novel miRNA involved in cancer [35][36][37]. Recently studies showed that miR-141-3p might participate in the progression of CRC by directly targeting EGFR [38], TRAF5 [39] and ZEB1 [40].…”

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy

“…Genistein and daidzein are the most studied compounds of this subgroup in terms of medical applications. Nevertheless, other isoflavones such as glabridin and alpinumisoflavone have raised interest as potential cancer medicines in various types of cancer such as breast, liver, or thyroid cancers [ 131 , 132 ].…”