<i>Retracted:</i> HMGB1 regulates SNAI1 during NSCLC metastasis, both directly, through transcriptional activation, and indirectly, in a RSF1‐IT2‐dependent manner

Wu, Xiaojin; Chen, Yuan‐yuan; Guo, Wenkai; Li, Tao; Dong, Hai‐bei; Wang, Wei; Xie, Min; Ma, Gao-Lei; Pei, Dong‐Sheng

doi:10.1002/1878-0261.12691

Cited by 15 publications

(8 citation statements)

References 49 publications

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“…The p73 protein is known to regulate the genes responsible for metastasis, but the direct association is not always established. For example, HMGB1, a putative p73 target that can regulate p73-mediated transactivation [ 129 , 130 ], is associated with EMT, metastasis, and poor prognosis in breast, lung, and other cancer types [ 55 , 131 , 132 , 133 ].…”

Section: Activation Of Invasion and Metastasismentioning

confidence: 99%

Dual Role of p73 in Cancer Microenvironment and DNA Damage Response

Rozenberg

Zvereva

Dalina

et al. 2021

Cells

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Understanding the mechanisms that regulate cancer progression is pivotal for the development of new therapies. Although p53 is mutated in half of human cancers, its family member p73 is not. At the same time, isoforms of p73 are often overexpressed in cancers and p73 can overtake many p53 functions to kill abnormal cells. According to the latest studies, while p73 represses epithelial–mesenchymal transition and metastasis, it can also promote tumour growth by modulating crosstalk between cancer and immune cells in the tumor microenvironment, M2 macrophage polarisation, Th2 T-cell differentiation, and angiogenesis. Thus, p73 likely plays a dual role as a tumor suppressor by regulating apoptosis in response to genotoxic stress or as an oncoprotein by promoting the immunosuppressive environment and immune cell differentiation.

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Section: Activation Of Invasion and Metastasismentioning

confidence: 99%

Dual Role of p73 in Cancer Microenvironment and DNA Damage Response

Rozenberg

Zvereva

Dalina

et al. 2021

Cells

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“…Our study reveals the role of these lncRNAs in ferroptosis and progression of tumor, providing a significant reference for future in-depth experimental studies. Interestingly, in lung cancer, RSF1-IT2 functions as a ceRNA to sponge miR-129-5p targeting SNAI1 and HMGB1, facilitating tumor metastasis and invasion ( Wu et al, 2020 ). Nevertheless, RSF1-IT2 is linked to better clinical outcomes in the TCGA-STAD cohort.…”

Section: Discussionmentioning

confidence: 99%

A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Therapeutic Response of Gastric Cancer

Xiao

Liu

Yuan

et al. 2021

Front. Cell Dev. Biol.

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Background: Accumulating literature demonstrates that long noncoding RNAs (lncRNAs) are involved in ferroptosis and gastric cancer progression. However, the predictive value of ferroptosis-related lncRNAs for prognosis and therapeutic response is yet to be elucidated in gastric cancer (GC).Method: The transcriptomic data and corresponding clinical information of GC patients were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) database. The association between ferroptosis-related lncRNAs and ferroptosis regulators was analyzed by Spearman correlation analysis. Then, we established a risk predictive model based on the ferroptosis-related lncRNAs using multivariate Cox regression analysis. Furthermore, we performed correlation analysis for the risk score and characteristics of biological processes, immune landscape, stromal activity, genomic integrity, drug response, and immunotherapy efficacy.Results: We constructed a 17-ferroptosis-related-lncRNA signature via multivariate Cox analysis to divide patients into two groups: low- and high-risk groups. The low-risk group was linked to prolonged overall survival and relapse-free survival. The risk score had good predictive ability to predict the prognosis of GC patients compared with other clinical biomarkers. We found that the high-risk group was associated with activation of carcinogenetic signaling pathways, including stromal activation, epithelial-mesenchymal-transition (EMT) activation, and immune escape through integrated bioinformatics analysis. In contrast, the low-risk group was associated with DNA replication, immune-flamed state, and genomic instability. Additionally, through Spearman correlation analysis, we found that patients in the high-risk group may respond well to drugs targeting cytoskeleton, WNT signaling, and PI3K/mTOR signaling, and drugs targeting chromatin histone acetylation, cell cycle, and apoptosis regulation could bring more benefits for the low-risk group. The high-risk group was associated with poor immunotherapy efficacy.Conclusion: Our study systematically evaluated the role of ferroptosis-related lncRNAs in t tumor microenvironment, therapeutic response, and prognosis of GC. Risk score–based stratification could reflect the characteristic of biological processes, immune landscape, stromal activity, genomic stability, and pharmaceutical profile in GC patients. The ferroptosis-related lncRNA signature could serve as a reliable biomarker to predict prognosis and therapeutic response of patients with GC.

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“…Importantly, upregulated RSF1-IT2 induced by HMGB1 was strongly associated with tumor metastasis in xenograft nude mice. 44 These findings suggest that HMGB1 and its related lncRNAs may be potential therapeutic targets for NSCLC.…”

Section: Molecular Mechanisms Of Lncrnas In Lung Cancer Metastasismentioning

confidence: 99%

Revisiting Lung Cancer Metastasis: Insight From the Functions of Long Non-coding RNAs

Huang

Zhu

Liang

et al. 2021

Technol Cancer Res Treat

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Globally, lung cancer is the most common cause of cancer-related deaths. After diagnosis at all stages, <7% of patients survive for 10 years. Thus, diagnosis at later stages and the lack of effective and personalized drugs reflect a significant need to better understand the mechanisms underpinning lung cancer progression. Metastasis should be responsible for the high lethality and recurrence rates seen in lung cancer. Metastasis depends on multiple crucial steps, including epithelial–mesenchymal transition, vascular remodeling, and colonization. Therefore, in-depth investigations of metastatic molecular mechanisms can provide valuable insights for lung cancer treatment. Recently, long noncoding RNAs (lncRNAs) have attracted considerable attention owing to their complex roles in cancer progression. In lung cancer, multiple lncRNAs have been reported to regulate metastasis. In this review, we highlight the major molecular mechanisms underlying lncRNA-mediated regulation of lung cancer metastasis, including (1) lncRNAs acting as competing endogenous RNAs, (2) lncRNAs regulating the transduction of several signal pathways, and (3) lncRNA coordination with enhancer of zeste homolog 2. Thus, lncRNAs appear to execute their functions on lung cancer metastasis by regulating angiogenesis, autophagy, aerobic glycolysis, and immune escape. However, more comprehensive studies are required to characterize these lncRNA regulatory networks in lung cancer metastasis, which can provide promising and innovative novel therapeutic strategies to combat this disease.

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Retracted: HMGB1 regulates SNAI1 during NSCLC metastasis, both directly, through transcriptional activation, and indirectly, in a RSF1‐IT2‐dependent manner

Cited by 15 publications

References 49 publications

Dual Role of p73 in Cancer Microenvironment and DNA Damage Response

Dual Role of p73 in Cancer Microenvironment and DNA Damage Response

A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Therapeutic Response of Gastric Cancer

Revisiting Lung Cancer Metastasis: Insight From the Functions of Long Non-coding RNAs

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