<i>Retracted:</i> LINC00311 promotes cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in human papillary thyroid cancer

Gao, Yu; Wang, Fan; Zhang, Li; Kang, Mei; Zhu, Liyang; Xu, Liping; Liang, Wei; Zhang, Wei

doi:10.1002/cam4.2815

Cited by 16 publications

(10 citation statements)

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“…In another study, Li et al found that estrogen receptor b (ERb) and lncRNA H19 are overexpressed in PTC-CSC suggesting a positive regulatory interaction of both factors in order to induce and maintain the cancer stem-like features (181). Also, lncRNA LINC00311 seems to have a key role in promoting the stem-like features by regulating the miR-330-5p/TLR4 pathway (182). Moreover, BANCR (BRAF-activated noncoding RNA) regulates the expression of CSC markers LGR5 and EpCAM via the c-Raf/ MEK/ERK signaling pathway (183).…”

Section: Other Noncoding Rnas Deregulated In Ptc-lncrna and Circrnamentioning

confidence: 99%

MicroRNAs in Papillary Thyroid Cancer: What Is New in Diagnosis and Treatment

et al. 2022

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IntroductionPapillary thyroid cancer (PTC) accounts for up to 80% of thyroid malignancies. New diagnostic and therapeutic options are suggested including innovative molecular methods. MicroRNAs (miRNAs) are nonprotein coding single-stranded RNAs that regulate many cell processes. The aim of the present study is to review the deregulated miRNAs associated with PTCs.MethodsA bibliographic research was conducted, resulting in 272 articles referred to miRNAs and PTC. Regarding our exclusion criteria, 183 articles were finally included in our review.ResultsA remarkably large number of miRNAs have been found to be deregulated during PTC manifestation in the literature. The deregulated miRNAs are detected in tissue samples, serum/plasma, and FNA samples of patients with PTC. These miRNAs are related to several molecular pathways, involving genes and proteins responsible for important biological processes. MiRNA deregulation is associated with tumor aggressiveness, including larger tumor size, multifocality, extrathyroidal extension, lymphovascular invasion, lymph node and distant metastasis, and advanced tumor node metastasis stage.ConclusionMiRNAs are proposed as new diagnostic and therapeutic tools regarding PTC. They could be essential biomarkers for PTC diagnosis applied in serum and FNA samples, while their contribution to prognosis is of great importance.

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Section: Other Noncoding Rnas Deregulated In Ptc-lncrna and Circrnamentioning

confidence: 99%

MicroRNAs in Papillary Thyroid Cancer: What Is New in Diagnosis and Treatment

et al. 2022

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“…miR-193a-5p directly targets SPOCK1 in hepatocellular carcinoma to repress its malignancy ( 39 ). Additionally, miR-330-5p and miR-326 have both been demonstrated to play tumor-suppressive roles in PTC progression ( 20 , 21 ). However, research on miR-193a-5p in PTC is limited.…”

Section: Discussionmentioning

confidence: 99%

“…For example, miR-206 suppresses drug resistance to Euthyrox by targeting MAP4K3 ( 19 ). A recent study showed that miR-330-5p mediates the positive regulation of long intergenic non-protein-coding RNA 003311 on cancer stem-like features in PTC ( 20 ). miR-326 suppresses PTC cell proliferation and metastasis by inhibiting MAPK1 and erb-b2 receptor tyrosine kinase (ERBB) 4 ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0001666 sponges miR‑330‑5p, miR‑193a‑5p and miR‑326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4

Zhang

Wang

et al. 2021

Oncol Rep

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Circular RNAs (circRNAs) are a group of regulators that affect the aggressive behaviors of several types of cancer. Hsa_circ_0001666 (also referred to as hsa_circ_000742) is a newly discovered circRNA that is upregulated in human papillary thyroid carcinoma (PTC) based on microarray analysis. However, the role of hsa_circ_0001666 in PTC progression remains unknown. Thus, the aim of the present study was to determine the potential function and underlying mechanism of hsa_circ_0001666 in PTC. The results demonstrated that hsa_circ_0001666 was upregulated in both PTC clinical samples and cell lines. Its expression was associated with lymph node metastasis of patients with PTC. Knocking down hsa_circ_0001666 expression inhibited cell proliferation, as evidenced by decreased cell viability, arrest of cell cycle progression at the G 1 phase and an increase in cell cycle-associated proteins. Apoptosis rates and expression levels of pro-apoptotic proteins were also increased by silencing hsa_circ_0001666. In xenograft experiments, the oncogenic effect of hsa_circ_0001666 on tumor growth was verified. Additionally, luciferase reporter assays showed that hsa_circ_0001666 and ETS variant transcription factor 4 (ETV4) shared common binding sites with three microRNAs [(miRNA/miR)-330-5p, miR-193a-5p and miR-326]. Knockdown of these miRNAs separately reversed the inhibitory effect of hsa_circ_0001666 small interfering RNAs on PTC tumor aggressiveness, and ETV4 overexpression also induced a similar effect to that of miRNA inhibitors. Thus, hsa_circ_0001666 may function as an oncogene, promoting PTC tumorigenesis via the miR-330-5p/miR-193a-5p/miR-326/ETV4 pathway. This provides a basis for identifying potential novel therapeutic targets for PTC.

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“…Several miRNAs and lncRNAs have found to be dysregulated in multiple subtypes of TC. Recently, two lncRNAs, lncRNA -LINC00311 and lncRNA-H19 were identified as specific promotors of cancer stem-like properties in PTC ( Li et al, 2018 ; Gao et al, 2020 ). Similarly, two miRNAs: miR-148a and antisense-miR-21, were both found to significantly inhibit TCSCs in ATC cells ( Haghpanah et al, 2016 ; Sheng et al, 2016 ).…”

Section: Autophagy and Epithelial-to-mesenchymal Transition: Invasion...mentioning

confidence: 99%

Targeting Autophagy in Thyroid Cancer: EMT, Apoptosis, and Cancer Stem Cells

Holm

Yeo

Turner

et al. 2022

Front. Cell Dev. Biol.

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Autophagy is a highly conserved recycling process through which cellular homeostasis is achieved and maintained. With respect to cancer biology, autophagy acts as a double-edged sword supporting tumor cells during times of metabolic and therapeutic stress, while also inhibiting tumor development by promoting genomic stability. Accumulating evidence suggests that autophagy plays a role in thyroid cancer, acting to promote tumor cell viability and metastatic disease through maintenance of cancer stem cells (CSCs), supporting epithelial-to-mesenchymal transition (EMT), and preventing tumor cell death. Intriguingly, well-differentiated thyroid cancer is more prevalent in women as compared to men, though the underlying molecular biology driving this disparity has not yet been elucidated. Several studies have demonstrated that autophagy inhibitors may augment the anti-cancer effects of known thyroid cancer therapies. Autophagy modulation has become an attractive target for improving outcomes in thyroid cancer. This review aims to provide a comprehensive picture of the current knowledge regarding the role of autophagy in thyroid cancer, focusing on the potential mechanism(s) through which inhibition of autophagy may enhance cancer therapy and outcomes.

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Retracted: LINC00311 promotes cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in human papillary thyroid cancer

Cited by 16 publications

References 50 publications

MicroRNAs in Papillary Thyroid Cancer: What Is New in Diagnosis and Treatment

MicroRNAs in Papillary Thyroid Cancer: What Is New in Diagnosis and Treatment

Circular RNA hsa_circ_0001666 sponges miR‑330‑5p, miR‑193a‑5p and miR‑326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4

Targeting Autophagy in Thyroid Cancer: EMT, Apoptosis, and Cancer Stem Cells

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