Retracted: Long noncoding RNA LINC00052 inhibits colorectal cancer metastasis by sponging microRNA‐574‐5p to modulate CALCOCO1 expression

Abstract

The dysregulation of long‐chain noncoding ribonucleic acid (lncRNA) is a common phenomenon in many human cancers. Some studies on the biological function of long intergenic non‐protein‐coding RNA 52 (LINC00052) in cancer indicate that this gene can act as either oncogene or tumor suppressor in some kinds of cancers, such as breast cancer, gastric cancer, liver cancer, and lung cancer. However, the biological function of LINC00052 in colorectal cancer (CRC) has not been studied. Quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR) and Western blot (WB) techniques were applied to detect the expression levels of LINC00052, miR‐574‐5p, and calcium‐binding and coiled‐coil domain 1 (CALCOCO1) in CRC cells and tissues. We authenticated the biological function of LINC00052 and miR‐574‐5p in CRC, and find some target genes for LINC00052 and miR‐574‐5p via bioinformatics methods. Dual‐luciferase reporter gene assay was performed to identify the interaction between LINC00052 and miR‐574‐5p or CALCOCO1 and miR‐574‐5p. The results demonstrated that LINC00052 was downregulated in CRC tissues compared with their adjacent tissues. And LINC00052 could suppress CRC cells metastasis both in vivo and in vitro. Beyond that, miR‐574‐5p was upregulated in CRC tissues, and as an oncogene, it accelerated CRC cell migration and invasion. More importantly, the results of our research demonstrated that LINC00052 could regulate the expression of CALCOCO1 via sponging miR‐574‐5p in CRC. Overall, our study illuminated the lncRNA‐miRNA functional networks in CRC, and these results might provide a new research direction for the diagnosis and treatment of CRC.

LncRNA SNHG1 promotes EMT process in gastric cancer cells through regulation of the miR-15b/DCLK1/Notch1 axis

“…Additionally, the relationship between lncRNA and microRNA (miRNA) in progression of multiple diseases has been extensively studied. For instance, a previous study demonstrated that lnc00052 could regulate CALCOCO1 expression via regulating miR-574-5p in colorectal cancer (CRC) [38]. Moreover, some researchers have found that miRNA can be regulated by lncRNA to regulate the EMT process of cancer [39][40][41].…”

LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sjögren’s syndrome patients

“…These immune cells, inflammatory cytokines, and signaling pathways were reported to be important in the pathogenesis of pSS. LOXL2 (correlated with LINC00426), CALCOCO1 (correlated with LINC00426), CRIP2 (correlated with TPTEP1-202), HSD17B11 (correlated with CYTOR), and SLC27A1 (upstream of BISPR) could regulate the metastasis of the PBMCs to regulate the corresponding cell function and the release of cytokines [40][41][42][43][44] , which could provide new insights into the pathogenesis of pSS. LncRNA-PVT1 participated in the regulation of cell metabolism through reprogramming glycolysis in CD4+ T cells to regulate immunity have been reported recently 45 , and similar to our results, LncRNAs regulating immunity through cell metabolism provided new direction for the pathogenesis of pSS.…”

hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p

“…In addition, the expression of miR-574-5p is regulated by long non-coding RNA (lncRNA) in cancers. For example, lncRNA PTCSC3 inhibited cervical carcinoma cell proliferation and invasion by sponging miR-574-5p, and LINC00052 inhibited metastasis by regulating miRNA-574-5p in colorectal cancer 27 , 28 . However, the sponge adsorption effect of circRNA on miR-574-5p has not been studied.…”