<i>Retracted</i>: MiR‐141‐3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer <i>via</i> Targeting Yin Yang 1

Fang, Ming; Huang, Wenlong; Wu, Xinchi; Gao, Yuan; Ou, Jing; Zhang, Xiaolan; Li, Yanyun

doi:10.1002/ar.23940

Cited by 34 publications

(18 citation statements)

References 36 publications

(43 reference statements)

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“…However, little is known about the role of miR‐141‐3p in PTC. Our previous studies revealed that miR‐141‐3p alleviated PTC progression through negative regulating YinYang 1 expression (Fang et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Retracted: Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Upregulating miR‐141‐3p

Fang

Liu

et al. 2019

The Anatomical Record

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Alpinumisoflavone (AIF) as a principal active ingredient of traditional Chinese herb Derris eriocarpa exerts a broad spectrum of anticancer activities against solid tumors. However, little is known about the effect of AIF on papillary thyroid cancer (PTC). Objectives of this study are to investigate the effect of AIF on cell growth, apoptosis, and metastasis of PTC cells and uncover its underlying mechanisms. Results showed that AIF treatment notably suppressed cell viability, migration, invasion, and epithelial–mesenchymal transition (EMT) process, as well as induced apoptotic cell death. In addition, microarray analysis results revealed that miR‐141‐3p level was dramatically elevated upon AIF insulation, suggesting that miR‐141‐3p may mediate the suppressive role of AIF against PTC. Moreover, miR‐141‐3p knockdown effectively reversed the effects of AIF on cell growth, migration, invasion, and EMT, while promoted PTC cell apoptosis escape. Furthermore, in vivo findings also confirmed that the antigrowth and antimetastasis activities of AIF were, at least partly, mediated by upregulation of miR‐141‐3p. Overall, AIF could serve as a potential anticancer compound for PTC treatment. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:1842–1850, 2020. © 2019 American Association for Anatomy

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Section: Discussionmentioning

confidence: 99%

“…Wang et al revealed that miR‐141‐3p functions as a tumor suppressor via downregulating ATF5 (Wang et al, ). More recently, our study revealed that miR‐141‐3p exerts inhibitory effects on cell proliferation and metastasis by downregulating Yin Yang 1(YY1) (Fang et al, ).…”

Section: Introductionmentioning

confidence: 95%

Retracted: Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Upregulating miR‐141‐3p

Fang

Liu

et al. 2019

The Anatomical Record

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“…Although several studies have reported the downexpression of miR-200 family members in lung, 15 colon, 16 or breast tumors, 11 upregulation of miR-200 is upregulated in non-small-cell lung cancer 17 . Furthermore, enforced miR-200 expression promotes metastatic spread in breast cancer models,18, 19 but overexpression of miR-141 or miR-429 has been associated with a suppressor gene function in several tumor types 20, 21, 22, 23…”

Section: Introductionmentioning

confidence: 99%

Expression and Role of MicroRNAs from the miR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer

Díaz‐Riascos

Ginestà

Fabregat

et al. 2019

Molecular Therapy - Nucleic Acids

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MicroRNAs from the miR-200 family are commonly associated with the inhibition of the metastatic potential of cancer cells, following inhibition of ZEB transcription factors expression and epithelial-to-mesenchymal transition. However, previous studies performed in pancreatic adenocarcinoma revealed a more complex picture challenging this canonical model. To gain better insights into the role of miR-200 family members in this disease, we analyzed the expression of miR-200a, miR-200b, miR-200c, miR-141, miR-429, and miR-205, and ZEB1, ZEB2, and CDH1 in pancreatic tumors and matching normal adjacent parenchyma and patient-derived xenografts. We found that miR-200a, miR-429, and miR-205 are frequently overexpressed in pancreatic tumors, whereas CDH1 is downregulated, and ZEB1 and ZEB2 levels remain unchanged. Furthermore, we measured a positive correlation between miR-200 family members and CDH1 expression, and a negative correlation between ZEB1 and miR-200c, miR-141, and miR-205 expression, respectively. Interestingly, we identified significant changes in expression of epithelial-to-mesenchymal transition regulators and miR-200 members in patient-derived xenografts. Lastly, functional studies revealed that miR-141 and miR-429 inhibit the tumorigenic potential of pancreatic cancer cells. Taken together, this comprehensive analysis strongly suggests that miRNAs from the miR-200 family, and in particular miR-429, may act as a tumor suppressor gene in pancreatic cancer.

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“…miR-141-3p and miR-150 were separately demonstrated by different studies to be inversely associated with TNM stage and lymph node metastasis in PTC patients (53,58). Similarly, the inverse association between miR-199b-5p or miR-7 and TNM stage was shown in PTC patients (55,59).…”

Section: Ncrnas Playing Role As Prognostic Factors Of Thyroid Cancermentioning

confidence: 86%

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Tabatabaeian¹,

Yang²,

Tay³

2020

Preprint

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Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.

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Retracted: MiR‐141‐3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer via Targeting Yin Yang 1

Cited by 34 publications

References 36 publications

Retracted: Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Upregulating miR‐141‐3p

Retracted: Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Upregulating miR‐141‐3p

Expression and Role of MicroRNAs from the miR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

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