Retracted: Tumor Protein D52-Like 2 Contributes to Proliferation of Breast Cancer Cells

Yang, Mingshi; Wang, Xueyao; Jia, Jiaoyuan; Gao, Hongwen; Chen, Peng; Sha, Xianliang; Wu, Shan

doi:10.1089/cbr.2014.1723

Cited by 11 publications

(25 citation statements)

References 23 publications

(24 reference statements)

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“…40,41 Yang et al demonstrated that knockdown of TPD52L2 (a member of the TPD52) suppressed the proliferation and colony formation in BC cells. 42 Zhang et al found that TPD52 expression was markedly increased in BC tissues and cells, and deficiency of miR-449 promoted proliferation and metastasis of BC cells through regulating TPD52. 27 In our research, results uncovered that TPD52 expression was enhanced in TNBC tissues and cells.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of lncRNA PCAT6 Enhances Radiosensitivity in Triple-Negative Breast Cancer Cells by Regulating miR-185-5p/TPD52 Axis

Shi¹,

Wu²,

Liu³

et al. 2020

OTT

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Background: Long non-coding RNAs (lncRNAs) have been reported to play essential roles in regulating the radiosensitivity of cancers. Prostate cancer-associated transcript 6 (PCAT6) exerts oncogenic roles in several tumors. However, the roles of PCAT6 and its underlying mechanism in regulating the radiosensitivity of triple-negative breast cancer (TNBC) have not been investigated. Methods: The expression levels of PCAT6, microRNA-185-5p (miR-185-5p) and tumor protein D52 (TPD52) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability, apoptosis and colony formation were assessed by Cell Counting Kit-8 (CCK-8) assay, flow cytometry and colony formation assay, respectively. The interaction between miR-185-5p and PCAT6 or TPD52 was predicted by bioinformatics analysis and verified by dual-luciferase reporter assay. Western blot was carried out to detect the protein level of TPD52. Results: PCAT6 and TPD52 were highly expressed and miR-185-5p was lowly expressed in TNBC tissues and cells, which was associated with an aggressive tumor phenotype in patients, affecting lymph node metastasis and clinical stage. PCAT6 or TPD52 knockdown or miR-185-5p overexpression enhanced the radiosensitivity of TNBC cells via inhibiting proliferation and inducing apoptosis. PCAT6 directly interacted with miR-185-5p and negatively regulated miR-185-5p expression. Moreover, TPD52 was confirmed as a target of miR-185-5p. Besides, PCAT6 regulated the radiosensitivity of TNBC cells through acting as a molecular sponge of miR-185-5p to modulate TPD52 expression. Conclusion: Knockdown of PCAT6 promoted the radiosensitivity of TNBC cells through regulating miR-185-5p/TPD52 axis, providing a vital theoretical basis to improve the radiotherapy efficiency of TNBC.

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Section: Discussionmentioning

confidence: 99%

Knockdown of lncRNA PCAT6 Enhances Radiosensitivity in Triple-Negative Breast Cancer Cells by Regulating miR-185-5p/TPD52 Axis

Shi¹,

Wu²,

Liu³

et al. 2020

OTT

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“…PubMed ''similar'' searches were performed to identify papers that PubMed recommended as similar to one index paper (Yang et al 2015). The PubMed ''similar'' search 4 is based on a similarity function that differently weights words from the abstract, title and MeSH words (Medical Subject Headings).…”

Section: Pubmed Corpusmentioning

confidence: 99%

“…The PubMed ''similar'' search 4 is based on a similarity function that differently weights words from the abstract, title and MeSH words (Medical Subject Headings). When searching for papers ''similar'' to Yang et al (2015), the retrieved set may contain papers that are similar or quite dissimilar, as mea-sured using intertextual distance (see below). Nevertheless, a PubMed ''similar'' search can be viewed as a first step to identify a set of papers with a greater chance of being similar (within the meaning of intertextual distance) to members of the index corpus.…”

Section: Pubmed Corpusmentioning

confidence: 99%

“…Google Scholar alerts and PubMed searches identified 5 TPD52L2 studies (the index corpus) published in 4 different journals between 2014 and 2015, with no apparent overlap in authorship (He et al 2015;Pan et al 2015;Wang et al 2014;Xu et al 2015;Yang et al 2015). The articles' stated aims were to perform gene knockdowns of TPD52L2 in cancer cell line(s) corresponding to different cancer types (breast cancer, gastric cancer, glioma, liver cancer, oral squamous cell carcinoma) ( Table 2).…”

Section: Visual Analysis Of Index Corpusmentioning

confidence: 99%

“…The aim of this study was to highlight a set of questionable papers/practices by explaining why these papers are questionable and how they were identified. Through reading the literature, one of us (JAB) identified 5 studies published between 2014 and 2015 that commonly described TPD52L2 knockdowns performed in 1-2 human cancer cell lines representing different cancer types (Wang et al 2014;He et al 2015;Pan et al 2015;Xu et al 2015;Yang et al 2015). The TPD52L2 gene was first reported by JAB and colleagues (Nourse et al 1998) and is a member of the TPD52 gene family .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Striking similarities between publications from China describing single gene knockdown experiments in human cancer cell lines

2016

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International audienceComparing 5 publications from China that described knockdowns of the human TPD52L2 gene in human cancer cell lines identified unexpected similarities between these publications, flaws in experimental design, and mis-matches between some described experiments and the reported results. Following communications with journal editors, two of these TPD52L2 publications have been retracted. One retraction notice stated that while the authors claimed that the data were original, the experiments had been out-sourced to a biotechnology company. Using search engine queries, automatic text-analysis, different similarity measures, and further visual inspection, we identified 48 examples of highly similar papers describing single gene knockdowns in 1–2 human cancer cell lines that were all published by investigators from China. The incorrect use of a particular TPD52L2 shRNA sequence as a negative or non-targeting control was identified in 30/48 (63%) of these publications, using a combination of Google Scholar searches and visual inspection. Overall, these results suggest that some publications describing the effects of single gene knockdowns in human cancer cell lines may include the results of experiments that were not performed by the authors. This has serious implications for the validity of such results, and for their application in future research

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Development of modern approach to absorbed dose assessment in radionuclide therapy, based on Monte Carlo method simulation of patient scintigraphy

Lysak

Климанов

Narkevich

2017

J. Phys.: Conf. Ser.

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Retracted: Tumor Protein D52-Like 2 Contributes to Proliferation of Breast Cancer Cells

Abstract: Cancer Biotherapy and Radiopharmaceuticals (CBR) is officially retracting the published article by

Cited by 11 publications

References 23 publications

<p>Knockdown of lncRNA <em>PCAT6</em> Enhances Radiosensitivity in Triple-Negative Breast Cancer Cells by Regulating<em> miR-185-5p</em>/<em>TPD52</em> Axis</p>

<p>Knockdown of lncRNA <em>PCAT6</em> Enhances Radiosensitivity in Triple-Negative Breast Cancer Cells by Regulating<em> miR-185-5p</em>/<em>TPD52</em> Axis</p>

Striking similarities between publications from China describing single gene knockdown experiments in human cancer cell lines

Development of modern approach to absorbed dose assessment in radionuclide therapy, based on Monte Carlo method simulation of patient scintigraphy

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