<i>S</i>,<i>S</i>-Diphenylsulfilimine

Furukawa, Naomichi; Yoshimura, Toshiaki

doi:10.1002/047084289x.rd439

Cited by 7 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cortical astrocytes were derived from 2-day-old mice (ICR) as described previously [9] with minor modi¢cations. After removal of the meninges, the cerebral cortex was cut into small pieces, and washed in Leibowitz L-15 medium.…”

Section: Astrocyte Culturementioning

confidence: 99%

Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures

et al. 2004

View full text Add to dashboard Cite

We found that prostaglandin (PG) D 2 and PGE 2 , which are major PGs in the brain of mammals, powerfully induced the secretion of nerve growth factor (NGF) from cultured mouse astrocytes; PGE 2 or PGD 2 induced an approximately 12-or 19-fold increase in NGF secretion after a 24-h incubation, respectively. Moreover, it was found that the sequential metabolites of PGD 2 , PGJ 2 , v v 12 -PGJ 2 , and 15-deoxy-v v 12;14 -PGJ 2 , induced the NGF secretion to the culture medium strikingly (60^98-fold of the control after a 24-h incubation). NGF secretion induced by the J 2 series of PGs was accompanied by the increased expression of NGF mRNA. These PGs also stimulated the secretion/synthesis of brain-derived neurotrophic factor (BDNF). Our ¢ndings suggest that PGs play a neuroprotective role by inducing NGF and BDNF production in the central nervous system.

show abstract

Section: Astrocyte Culturementioning

confidence: 99%

Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In 1982, Furukawa and coworkers discovered some benzylsubstituted imidazoles that were specific Ang-II antagonists [129]. These compounds served as leads to develop losartan [130], the first commercially available AT 1 antagonist, and valsartan [131] (structures 6 and 7) (Fig.…”

Section: Ace Inhibitorsmentioning

confidence: 99%

Endogenous Vasoactive Peptides

Webb

Ksander²

2010

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

The control of vasomotor tone regulates the overall cardiovascular system and its responses to physiological and pathophysiological stress. It provides differential blood flow to regional vascular beds under normal physiologic conditions, at times of normal stress, such as exercise, and during conditions of pathological stress, such as congestive heart failure. Although the vascular system regulates many of its functions at the site of the blood vessel itself, other factors that may control vascular tone include the autonomic nervous system, circulating hormones functioning in an endocrine role, and reflex metabolic control. Many newly discovered peptides were found to be widespread in autonomic and sensory neurons innervating the vasculature, and they possess potent vasoactive effects on many blood vessels. Vasoactive peptides have been shown to play an important role in many pathological situations, for example, asthma, arthritis, vascular headaches, hypertension, and other cardiovascular diseases. In this chapter, we will outline the evidence for the different actions of various vasoactive peptides, their interaction with other systems, the possible role they have in diseases, and the present and future therapeutic use of vasoactive peptide agonists and antagonists.

show abstract

“…Sweeney et al [9] also reported the preparation of 1 by the reaction of Cl 2 CHSH with HOF over CuCl 2 -KCl in low yield. 1 was reported to have been used as an acid catalyst in the dimerization of styrenes [10] and as lithium battery electrolyte [11]. The latter study claimed its advantage over conventional CF 3 SO 3 À Li þ by preventing passivation of the anodes and improving the low-temperature discharge performance of the batteries.…”

Section: Introductionmentioning

confidence: 99%