<i>Salmonella enterica</i>
            Serotype Typhimurium and Its Host-Adapted Variants

Rabsch, Wolfgang; Andrews, Helene L.; Kingsley, Robert A.; Prager, Rita; Tschäpe, Helmut; Adams, L. Garry; Bäumler, Andreas J.

doi:10.1128/iai.70.5.2249-2255.2002

Cited by 266 publications

(233 citation statements)

References 49 publications

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“…Such outcomes are also consequent on the dose and route of inoculation, as well as the genetic background and immune status of the host. Even within serovar Typhimurium, different strains isolated from animals or humans vary in virulence for mice (Heithoff et al 2008), and host-restricted variants such as pigeon-associated definitive type (DT)-2 and DT99 strains (Rabsch et al 2002) exist. Similarly, non-typhoidal serovars are typically linked with enteritis in the developed world, but are increasingly associated with fatal invasive disease of infants and the immuno-compromised in sub-Saharan Africa and Asia (Gordon 2008).…”

Section: Human Salmonellosis and Animal Reservoirsmentioning

confidence: 99%

Molecular insights into farm animal and zoonoticSalmonellainfections

Stevens

Humphrey

Maskell

2009

Phil. Trans. R. Soc. B

147

102

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Salmonella enterica is a facultative intracellular pathogen of worldwide importance. Infections may present in a variety of ways, from asymptomatic colonization to inflammatory diarrhoea or typhoid fever depending on serovar-and host-specific factors. Human diarrhoeal infections are frequently acquired via the food chain and farm environment by virtue of the ability of selected non-typhoidal serovars to colonize the intestines of food-producing animals and contaminate the avian reproductive tract and egg. Colonization of reservoir hosts often occurs in the absence of clinical symptoms; however, some S. enterica serovars threaten animal health owing to their ability to cause acute enteritis or translocate from the intestines to other organs causing fever, septicaemia and abortion. Despite the availability of complete genome sequences of isolates representing several serovars, the molecular mechanisms underlying Salmonella colonization, pathogenesis and transmission in reservoir hosts remain ill-defined. Here we review current knowledge of the bacterial factors influencing colonization of food-producing animals by Salmonella and the basis of host range, differential virulence and zoonotic potential.

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Section: Human Salmonellosis and Animal Reservoirsmentioning

confidence: 99%

Molecular insights into farm animal and zoonoticSalmonellainfections

Stevens

Humphrey

Maskell

2009

Phil. Trans. R. Soc. B

147

102

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“…Closely related specialist/generalist pairs can be found even within a particular Salmonella serovar. For example, whereas the majority of S. Typhimurium isolates are prototypical generalists, a clonal group designated S. Typhimurium phage type DT2 represents a specialist associated with septicemic infections in pigeons (reviewed in Rabsch et al 2002).…”

Section: Salmonella Enterica Serovarsmentioning

confidence: 99%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

173

134

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“…Clostridium difficile) and that the pathogenic effect of some enteric organisms is potentiated in a restricted host range or age group (e.g. Escherichia coli O157 : H7, Salmonella and Campylobacter) (Moxley, 2004;Rabsch et al, 2002).…”

Section: Introductionmentioning

confidence: 99%